|1.||Wang, George K: 2 articles (07/2010 - 05/2006)|
|2.||Fuller, Gregory N: 2 articles (07/2010 - 05/2006)|
|3.||Zhang, Wei: 2 articles (07/2010 - 05/2006)|
|4.||Griffioen, Arjan W: 2 articles (01/2010 - 10/2004)|
|5.||Kim, Kyung Hwan: 2 articles (12/2006 - 08/2003)|
|6.||Kim, Hyeyoung: 2 articles (12/2006 - 08/2003)|
|7.||Roman, Jesse: 2 articles (09/2005 - 04/2005)|
|8.||Han, ShouWei: 2 articles (09/2005 - 04/2005)|
|9.||Zhao, Jing: 1 article (02/2015)|
|10.||Jia, Lin-Tao: 1 article (02/2015)|
|1.||Neoplasm Metastasis (Metastasis)
05/20/2009 - "Increased expression of integrin alpha5, beta1 and decreased expression of ECM significantly correlated with LN metastasis of NSCLC. "
10/01/2006 - "The overexpression of integrin alpha5 beta1 may contribute to lymph node metastasis and play an inverse role, while E-CD may be a beneficial prognostic factor in patients with NSCLC."
10/01/2006 - "The expression of integrin alpha5 beta1 was significantly higher in NSCLC (58.5%) than that in normal lung tissue (16.7%), and also positively related with pathological characteristics (P = 0.021), lymph node metastasis (P = 0.006), and clinical stage (P = 0.002). "
08/01/2002 - "The relationship between the expression of integrin alpha5 and beta1 subunits and infiltration or metastasis was not significant. "
07/01/1998 - "For the first time, we found that several clones of integrin alpha5 subunit transfectants displayed dramatically reduced formation of lung colonies and cutaneous metastasis after intravenous injection into nude mice. "
04/15/2010 - "Thus, integrin alpha5 serves as a key mediator of Src and ErbB2-survival signaling in low adhesion states, which are necessary to block the pro-anoikis mediator Bim, and we suggest that this pathway represents a potential novel therapeutic target in ErbB2-positive tumors."
04/01/2010 - "These observations implicate integrin alpha5 upregulation as a molecular mechanism by which TMPRSS4 induces invasion and contributes to cancer progression."
08/01/2002 - "FAK is a better marker for carcinogenesis and the progression of cancer than integrin alpha5 and beta1 subunit, and it may be not only a transformation-linked enzyme but also a progression-linked enzyme."
08/01/2002 - "Cancerous tissues with stronger FAK expression (++ or +++) also had a higher expression of integrin alpha5 and beta1 subunits in the tumor and its unaffected margins. "
01/01/2000 - "In the node-negative patients, the overall survival rate for patients with integrin alpha5 overexpressed tumors was significantly worse than for those individuals whose tumors had normal integrin alpha5 expression (P = 0.016)."
07/01/2010 - "In the present study, we examined the mechanism through which the IGFBP2/integrin alpha5 interaction mediates enhanced glioma cell migration. "
07/01/2010 - "Based on these data we propose that the interaction between IGFBP2 and integrin alpha5 accelerates cell adhesion, and this, in turn, enhances JNK-mediated glioma cell migration."
05/19/2006 - "We first confirmed our microarray results by showing that the expression of integrin alpha5 is indeed up-regulated at the protein level in IGFBP2-overexpressing SNB19 glioma cells. "
07/01/2010 - "We have previously shown that a molecular interaction between insulin-like growth factor binding protein 2 (IGFBP2) and integrin alpha5 is necessary for the enhancement of cell migration in IGFBP2-overexpressing gliomas. "
04/21/2006 - "Taken together, the data reported here are consistent with the notion that the inhibition of glioma cell proliferation induced by tocopherols may be mediated, at least in part, by an increase in integrin alpha5 and beta1 expression. "
|4.||Hirschsprung Disease (Hirschsprung's Disease)
04/01/2006 - "As HIF-1alpha is known to be stabilized by ERBB2 signaling under normoxic conditions, we propose that alpha5 integrin is a major effector in this regulatory circuit and may represent the molecular basis for the HIF-1alpha-dependent aggressiveness observed in ERBB2-overexpressing breast carcinomas. "
01/01/2000 - "alpha5 integrin distribution and TGFbeta1 gene expression in supraglottic carcinoma: their role in neoplastic local invasion and metastasis."
11/15/2003 - "We have recently demonstrated that in breast carcinoma MCF7 cells MT1-MMP processes the alphav, alpha3, and alpha5 integrin precursors generating the respective mature S-S-linked heavy and light alpha-chains. "
09/10/2005 - "COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites."
03/30/1998 - "To determine the significance of absent alpha5beta1 integrin signaling, we transfected the cDNA coding for the alpha5 integrin sub-unit into the human colon-carcinoma cell line HT29, which constitutively lacks this subunit but does express the beta1 subunit. "
|1.||Proteins (Proteins, Gene)
|3.||Focal Adhesion Protein-Tyrosine Kinases
|4.||Membrane Proteins (Integral Membrane Proteins)
|6.||Messenger RNA (mRNA)