|1.||Lam, Kit S: 5 articles (11/2009 - 05/2005)|
|2.||Xiao, Wenwu: 3 articles (11/2009 - 01/2009)|
|3.||Yao, Nianhuan: 3 articles (11/2009 - 01/2009)|
|4.||Tsuji, Tsutomu: 3 articles (10/2009 - 01/2005)|
|5.||Marik, Jan: 3 articles (01/2009 - 05/2005)|
|6.||Chang, Xin-Zhong: 2 articles (04/2009 - 09/2008)|
|7.||Kreidberg, Jordan A: 2 articles (01/2009 - 08/2004)|
|8.||Liu, Ruiwu: 2 articles (01/2009 - 05/2005)|
|9.||Mizuno, Hiromi: 2 articles (02/2006 - 01/2005)|
|10.||Sano, Rikio: 2 articles (02/2006 - 01/2005)|
12/01/1998 - "In the present study using a model of SCLC tumor progression, overexpression of c-myc in a classic SCLC cell line, NCI H209, enhanced in vitro features of tumorigenesis, altered the relationships between cell and environment, and markedly down-regulated the expression of the alpha3 integrin subunit at both the transcript and protein levels. "
01/01/2009 - "Src activity alters alpha3 integrin expression in colon tumor cells."
01/01/2009 - "The in vivo targeting specificity was further verified by strong inhibition of tumor uptake of LXY1-biotin-SA-Cy5.5 complex when intravenously injecting the animals with anti-alpha 3 integrin antibody or excess unlabeled LXY1 prior to administrating the imaging probe. "
05/01/2002 - "Eighty percent of the tumors expressed the alpha6 or alpha3 integrin and 20% was integrin-negative. "
05/01/2002 - "The levels of the polarized alpha6/alpha3 integrin expression at the basal membrane of prostate tumor glands were determined by quantitative immunohistochemistry. "
|2.||Breast Neoplasms (Breast Cancer)
02/20/2009 - "In the current study, we investigated the involvement of CD151, c-Met, and integrin alpha3/alpha6 in the cellular morphogenesis of human breast cancer cells. "
01/08/2009 - "Using analytic flow cytometry, the binding affinity (K(d)) of 1 to alpha3 integrin on MDA-MB-231 breast cancer cells was determined to be approximately 0.4 microM. "
09/01/2008 - "Taken together, these results provide functional evidences that overexpression of AF1Q leads to a more progression in human breast cancer, at least in part, through regulating the integrin alpha3, Ets-1, MMP-2, EFP, and 14-3-3delta expression."
09/01/2008 - "Integrin alpha3, accompanied by up-regulation of Ets-1 and MMP-2, significantly enhanced the in vitro invasive potential of human breast cancer cells mediated by AF1Q. "
11/12/2009 - "Fluorescent microscopy and in vivo and ex vivo imaging studies demonstrated that 29 is an efficient in vivo targeting agent against alpha3 integrin of MDA-MB-231 breast tumor xenograft implant."
02/15/2006 - "This motif was previously shown to be crucial for alpha3 integrin expression in MKN1 gastric carcinoma cells. "
12/01/2003 - "These data indicate that alpha3beta1integrin is prominently expressed on certain esophageal carcinomas and that a specific carbohydrate unit is selectively displayed on the alpha(3) integrin subunit as well as on glycolipid on the cell surface. "
06/01/2004 - "Investigations have shown that down-regulation of alpha3 integrin subunit may contribute to enhanced tumorigenicity of c-myc-overexpressing small cell lung carcinoma, while the loss of an integrin expression is correlated with recurrence in node-negative lung carcinoma. "
05/01/1998 - "Decrease of the alpha 3 integrin chain was found in adenomas, together with that of alpha 6 and beta 4 chains in carcinomas. "
03/01/1994 - "All of them were found to induce homotypic cell aggregation of HT1080 fibrosarcoma and SN12C renal carcinoma cells, both of which express high levels of alpha 3 integrin. "
|4.||Melanoma (Melanoma, Malignant)
08/01/1999 - "Alpha3 integrin localization was documented in malignant melanoma cells, basal and suprabasal keratinocytes, melanocytes, blood vessels and in basement membrane material. "
07/01/1995 - "Here we have studied the role the alpha 3 integrin subunit in malignant melanoma cell migration and invasion into extracellular matrices. "
10/01/2009 - "When melanoma C8161 cells were treated with function-blocking antibodies to integrin alpha3 or alpha6, their chemotactic responses to LEC-CM were markedly reduced. "
08/01/2008 - "These compounds reduce the metastatic potential of melanoma cells by interfering with the expression/activity of cell adhesion molecules (alpha3 integrin) and matrix metalloproteinase (MMP-2)."
08/01/2008 - "Gonadotropin-releasing hormone agonists suppress melanoma cell motility and invasiveness through the inhibition of alpha3 integrin and MMP-2 expression and activity."
|5.||Colonic Neoplasms (Colon Cancer)
01/01/2009 - "This study shows that Src overexpression downregulates alpha3 integrin total protein expression and localization to the cell surface of HCT116 colon cancer cells. "
12/01/2002 - "Among genes found differentially expressed, the CD63 tetraspanin, not previously recognized in colon cancer progression, and the alpha3 integrin chain were both up-regulated in low metastatic E2 cells and were analyzed for their functional role using adhesion, migration, and invasion assays. "
02/01/2002 - "Our data seem to suggest that low expression of integrin alpha3 is a useful indicator of a poor prognosis for colon cancer patients and that colon cancer progresses following collapse of the complex formed by integrin alpha3 with MRP-1/CD9 and KAI1/CD82."
02/01/2002 - "We investigated integrin alpha3 expression in 114 resected colon cancers using immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) to evaluate whether these experimental results are of relevance in the prognosis of actual colon cancers. "
02/01/2002 - "Recently, we established that a murine monoclonal antibody (MAb) MH8-4 inhibits the motility of the colon cancer cell line RPMI4788 and that it recognizes integrin alpha3. "
|2.||Integrin beta3 (GPIIIa)
|6.||Transforming Growth Factor beta1 (TGF beta 1)
|8.||Gonadotropin-Releasing Hormone (GnRH)
|1.||Heterologous Transplantation (Xenotransplantation)