RNA Cap-Binding Proteins (Cap Binding Protein)

Proteins that specifically bind to RNA CAPS and form nuclear cap binding protein complexes. In addition to stabilizing the 5' end of mRNAs, they serve a diverse array of functions such as enhancing mRNA transport out of the CELL NUCLEUS and regulating MRNA TRANSLATION in the CYTOPLASM.

Also Known As:

Networked: 60 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dussor, Gregory: 4 articles (01/2021 - 01/2017)
2.	Price, Theodore J: 3 articles (01/2021 - 01/2017)
3.	Conn, Crystal S: 2 articles (07/2021 - 01/2021)
4.	Ruggero, Davide: 2 articles (07/2021 - 01/2021)
5.	Moy, Jamie K: 2 articles (01/2020 - 01/2017)
6.	Pancrazio, Joseph J: 2 articles (01/2020 - 01/2017)
7.	Sonenberg, Nahum: 2 articles (01/2017 - 11/2009)
8.	Timpano, Sara: 2 articles (01/2017 - 05/2016)
9.	Uniacke, James: 2 articles (01/2017 - 05/2016)
10.	Buono, Roberta: 1 article (07/2021)

Related Diseases

1.	Infections 05/01/1985 - "In this study we show that human rhinovirus 14 is similar to poliovirus in that the inhibition of host cell translation that occurs during infection correlates with the proteolytic cleavage of an Mr 220,000 subunit of the cap-binding protein complex." 08/01/1985 - "Infection of HeLa cells by poliovirus results in proteolysis of the large subunit (P220) of the cap-binding protein complex. " 05/01/1985 - "By various criteria, the 24-kilodalton cap-binding protein is not structurally modified as a result of infection. " 01/01/2022 - "Recently, an eIF4E-type gene, novel cap-binding protein (nCBP), was reported to be associated with the infection of several viruses encoding triple gene block proteins (TGBps) in Arabidopsis. " 06/25/1989 - "The tripartite leader facilitates the translation of viral mRNAs at late but not early times after infection and eliminates the normal requirement for the eukaryotic initiation factor 4F or cap binding protein complex. "
2.	Inflammation (Inflammations) 11/09/1999 - "Overall, this study suggests that diverse mRNAs whose gene products have been implicated in a variety of stress responses, including inflammation, angiogenesis, and the response to serum, can use translational initiation mechanisms that require little or no intact cap binding protein complex eIF4F."
3.	Neoplasms (Cancer) 01/01/2004 - "Necropsy tissues from 11 cases were analyzed with 1 tumor specimen found to have HIV integrated in chromosome 22q13.2 and within 300 kb of HSCBCIP1 (CAP-binding protein complex interacting homologue). " 08/01/2022 - "We conducted receiver operating characteristic (ROC) curve analysis and compared the area under the ROC curve area under the curve (AUC) values to evaluate the sensitivity and specificity of nuclear cap binding protein subunit 2 (NCBP2) for the diagnosis of COAD in The Cancer Genome Atlas (TCGA) database. " 07/23/2021 - "The cap-binding protein eukaryotic initiation factor 4E (eIF4E) promotes translation of mRNAs associated with proliferation and survival and is an attractive target for cancer therapeutics. " 01/01/2017 - "This review will focus on a noncanonical cap-dependent translation initiation mechanism that utilizes the eIF4E homolog eIF4E2, a hypoxia-activated cap-binding protein that is implicated in hypoxic cancer cell migration, invasion, and tumor growth in mouse xenografts. " 02/01/2020 - "Eukaryotic initiation factor 4E(eIF4E), the mRNA cap-binding protein, has emerged as a key player to facilitate tumor progression through upregulated cap-dependent translation synchronized with enhanced cell division. "
4.	Hypoxia (Hypoxemia) 07/05/2023 - "Furthermore, we identified the cap-binding protein eIF4EHP as a main factor involved in 3'UTR-dependent translation under hypoxia. " 10/30/2007 - "Pioneer round of translation mediated by nuclear cap-binding proteins CBP80/20 occurs during prolonged hypoxia." 01/01/2017 - "This review will focus on a noncanonical cap-dependent translation initiation mechanism that utilizes the eIF4E homolog eIF4E2, a hypoxia-activated cap-binding protein that is implicated in hypoxic cancer cell migration, invasion, and tumor growth in mouse xenografts. " 05/13/2016 - "We have identified oxygen conditions where eIF4E is the dominant cap-binding protein (21% normoxia or standard cell culture conditions), where eIF4E2 is the dominant cap-binding protein (1% hypoxia or ischemic diseases and cancerous tumors), and where both cap-binding proteins act simultaneously to initiate the translation of distinct mRNAs (1-11% physioxia or during development and stem cell differentiation). " 03/01/2008 - "Hypoxia causes a rapid and sustained inhibition in mRNA translation that is characterized by both a transient phosphorylation of eukaryotic initiation factor 2-alpha (eIF2alpha) and by inhibition of the mRNA cap binding protein eIF4E via activation of two distinct inhibitory proteins, the mammalian target of rapamycin (mTOR) target 4E-BP1 and the eIF4E transporter 4E-T. "
5.	Human Influenza (Influenza) 01/01/2016 - "The conserved residues 318-483 in the PB2 subunit of influenza A polymerase is an independently folded cap-binding domain (PB2cap) that exhibits a distinct binding mode from other host cap-binding proteins, which suggests that PB2cap might be an ideal drug target. " 09/01/1982 - "Identification of the cap-binding protein of two strains of influenza A/FPV." 03/01/1982 - "Preincubation of capped reovirus mRNA with purified cellular cap binding protein reduced its primer effect on influenza transcriptase, whereas priming by ApG was not affected. "

Related Drugs and Biologics

1.	Eukaryotic Initiation Factor-4F (EIF4F)
2.	Eukaryotic Initiation Factor-4E
3.	Messenger RNA (mRNA)
4.	Proteins (Proteins, Gene)
5.	Peptide Initiation Factors (Initiation Factor)
6.	RNA Cap-Binding Proteins (Cap Binding Protein)
7.	Phosphotransferases (Kinase)
8.	TOR Serine-Threonine Kinases
9.	Eukaryotic Initiation Factor-4G (Eukaryotic Initiation Factor 4G)
10.	Mitogen-Activated Protein Kinase Kinases (MEKs)

Related Therapies and Procedures

1.	Oncolytic Virotherapy
2.	Therapeutics