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Integrin alphaVbeta3

An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Also Known As:
Integrin alpha-v beta-3; Receptors, alpha-v beta-3 Integrin; Vitronectin Receptor; alpha-v beta-3 Integrin Receptors; Integrin alpha v beta 3; Receptor, Vitronectin; Receptors, alpha v beta 3 Integrin; alpha v beta 3 Integrin Receptors; alpha-v beta-3, Integrin; alphaVbeta3, Integrin; beta-3, Integrin alpha-v
Networked: 555 relevant articles (15 outcomes, 67 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Chen, Xiaoyuan: 43 articles (02/2010 - 01/2004)
2. Liu, Shuang: 18 articles (02/2010 - 08/2003)
3. Cai, Weibo: 17 articles (11/2008 - 12/2005)
4. Liu, Zhaofei: 12 articles (02/2010 - 07/2006)
5. Wang, Fan: 12 articles (02/2010 - 07/2006)
6. Chen, Kai: 12 articles (03/2009 - 10/2006)
7. Tang, Chih-Hsin: 11 articles (10/2009 - 04/2005)
8. Schwaiger, Markus: 10 articles (12/2009 - 01/2004)
9. Fong, Yi-Chin: 10 articles (10/2009 - 03/2008)
10. Li, Zi-Bo: 8 articles (01/2009 - 07/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Glioma (Gliomas)
4. Bone Resorption
5. Lung Neoplasms (Lung Cancer)

Related Drugs and Biologics

1. Integrins
2. Peptides
3. Integrin alphaV
4. Small Interfering RNA (siRNA)
5. Radiopharmaceuticals
6. Biological Markers (Surrogate Marker)
7. Epidermal Growth Factor Receptor (EGF Receptor)
8. Cilengitide
9. Somatostatin Receptors (Somatostatin Receptor)
10. cyclic arginine-glycine-aspartic acid peptide

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Radiotherapy
3. Tooth Movement
4. Ligation
5. Occlusive Dressings (Occlusive Dressing)