|1.||Chen, Xiaoyuan: 43 articles (02/2010 - 01/2004)|
|2.||Liu, Shuang: 18 articles (02/2010 - 08/2003)|
|3.||Cai, Weibo: 17 articles (11/2008 - 12/2005)|
|4.||Liu, Zhaofei: 12 articles (02/2010 - 07/2006)|
|5.||Wang, Fan: 12 articles (02/2010 - 07/2006)|
|6.||Chen, Kai: 12 articles (03/2009 - 10/2006)|
|7.||Tang, Chih-Hsin: 11 articles (10/2009 - 04/2005)|
|8.||Schwaiger, Markus: 10 articles (12/2009 - 01/2004)|
|9.||Fong, Yi-Chin: 10 articles (10/2009 - 03/2008)|
|10.||Li, Zi-Bo: 8 articles (01/2009 - 07/2007)|
12/01/2009 - "Improvement of tumor uptake and tumor-to-background ratios is important for early detection of integrin alpha(v)beta(3)-positive tumors and/or noninvasive monitoring of therapeutic efficacy of antiangiogenic therapy."
03/01/2008 - "Dual integrin alpha(v)beta(3) and GRPR recognition showed significantly improved tumor-targeting efficacy and pharmacokinetics compared with (18)F-labeled RGD and BBN analogs. "
06/01/2003 - "Antagonists of integrin alpha V beta 3 suppress angiogenesis in many experimental models and are currently tested in clinical trials for their therapeutic efficacy against angiogenesis-dependent diseases, including cancer. "
06/10/2009 - "In the present study, we characterized integrin alphavbeta3-mediated tumor biological effects as a function of cellular KAI1 restoration and proved for the first time that KAI1, besides its already known physical crosstalk with beta1-integrins, also colocalizes with integrin alphavbeta3. "
03/11/2009 - "In this study, a novel functional SWNT based on an integrin alpha(v)beta(3) monoclonal antibody was developed and was used for cancer cell targeting in vitro. "
|2.||Breast Neoplasms (Breast Cancer)
12/01/2012 - "RGD binding to integrin alphavbeta3 affects cell motility and adhesion in primary human breast cancer cultures."
05/20/2009 - "Cell binding assay demonstrated that the high GRPR expressing breast cancer cells typically express low to moderate level of integrin alpha(v)beta(3), while high integrin alpha(v)beta(3) expressing breast cancer cells have negligible level of GRPR. "
01/01/2009 - "In MDA-MB231 human breast cancer cells examined under fluorescence microscopy, OPN-R3 ablates cell surface binding of OPN to its cell surface CD44 and alpha(v)beta(3) integrin receptors. "
06/15/2007 - "We conclude that CTGF plays a crucial role in migratory/invasive processes in human breast cancer by a mechanism involving activation of the integrin-alphavbeta3-ERK1/2-S100A4 pathway."
06/15/2007 - "CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway."
03/01/2007 - "Our previous studies demonstrated that downregulation of uPAR expression and restoration of p16 regress glioma growth in nude mice and downregulate alphavbeta3 integrin receptor expression. "
12/01/2009 - "Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography."
11/01/2009 - "An in vitro displacement assay was used to determine the integrin alpha(v)beta(3) binding affinity of MAG(2)-3G(3)-dimer against (125)I-c(RGDyK) bound to U87MG human glioma cells. "
12/25/2008 - "Integrin alpha(v)beta(3) binding affinities of 5 and 6 were determined by displacement of (125)I-echistatin bound to U87MG glioma cells. "
01/01/2003 - "alphavbeta3 integrin is highly expressed in malignant gliomas and plays a role in glioma growth. "
12/01/2008 - "Furthermore, a significant reduction in the ability of p85alpha(-/-) osteoclasts to adhere to as well as to migrate via integrin alphavbeta3 was observed, which was associated with reduced bone resorption. "
08/01/2005 - "Functional studies showed that alphaVbeta3 integrin-activated PKCalpha was involved in cell migration and osteoclast bone resorption, but had no effect on the ability of cells to attach to LM609, suggesting a role in events downstream of alphaVbeta3 integrin engagement."
03/12/2007 - "Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption."
03/01/2005 - "Osteoclastic bone resorption requires cell-matrix contact, an event mediated by integrin alphavbeta3, and subsequent cytoskeletal reorganization to form characteristic membrane domains such as the sealing zone and ruffled border. "
09/01/2003 - "Osteoclasts utilize alphavbeta3 integrin adhesion to bone matrix during bone resorption. "
|5.||Lung Neoplasms (Lung Cancer)
09/01/2007 - "Targeting the interaction between OPN and alphavbeta3 integrin could be effective for future development of anti-angiogenic therapeutic agents for patients with lung cancer."
06/01/2009 - "Here we found that OPN increased the migration via activation of alphavbeta3 integrin in human lung cancer cells (A549 cells). "
03/01/2009 - "Here we found CCL5 increased the migration and cell surface expression of alphavbeta3 integrin in human lung cancer cells (A549 cells). "
09/01/2007 - "Taken together, these results suggest that OPN plays a crucial role for tumor growth and angiogenesis of human lung cancer cells in vivo by interacting with alphavbeta3 integrin. "
09/01/2010 - "MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells."
|4.||Small Interfering RNA (siRNA)
|6.||Biological Markers (Surrogate Marker)
|7.||Epidermal Growth Factor Receptor (EGF Receptor)
|9.||Somatostatin Receptors (Somatostatin Receptor)
|10.||cyclic arginine-glycine-aspartic acid peptide
|1.||Heterologous Transplantation (Xenotransplantation)
|5.||Occlusive Dressings (Occlusive Dressing)