Cleavage Stimulation Factor

A RNA-binding protein that stimulates the cleavage of the 3' end of MRNA near the POLYADENYLATION site. It is a heterotrimer of 55-, 64- and 77-kDa subunits and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.

Also Known As:

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Feng, Linfei: 1 article (01/2022)
2.	Hou, Jun: 1 article (01/2022)
3.	Jing, Fengyang: 1 article (01/2022)
4.	Kong, Weihao: 1 article (01/2022)
5.	Liu, Jun: 1 article (01/2022)
6.	Ning, Yujie: 1 article (01/2022)
7.	Qin, Xiaofeng: 1 article (01/2022)
8.	Zhang, Meng-Hui: 1 article (01/2022)
9.	Zhou, Liming: 1 article (01/2022)
10.	Zhu, Youming: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "However, cleavage stimulation factor subunit 2 (CSTF2) was found to play a more critical regulatory role across cancers. " 01/01/2022 - "Cleavage Stimulation Factor Subunit 2: Function Across Cancers and Potential Target for Chemotherapeutic Drugs." 01/01/2022 - "Cleavage stimulation factor 2 (CSTF2) encodes a nuclear protein that is implicated in the development of various cancers. " 07/07/2011 - "Here, we show that the p53 C terminus associates with factors that are required for the ultraviolet (UV)-induced inhibition of the mRNA 3' cleavage step of the polyadenylation reaction, such as the tumor suppressor BARD1 and the 3' processing factor cleavage-stimulation factor 1 (CstF1). " 03/01/2003 - "By bioinformatics and microarray technologies, we found 3 genes, X55987(EDN, eosinophil-derived neurotoxin), AB011097 (ARTS-1, TNF receptor shedding regulator),and M85085(CStF, cleavage stimulation factor), which might be potential key tumor development relative genes that can be developed for therapy targets in the future."
2.	Lung Neoplasms (Lung Cancer) 01/01/2022 - "Cleavage stimulation factor 2 (CSTF2), an important regulator of APA, has been reported to have a tumorigenic function in urothelial carcinoma of the bladder and lung cancers. " 09/15/2011 - "Characterization of a cleavage stimulation factor, 3' pre-RNA, subunit 2, 64 kDa (CSTF2) as a therapeutic target for lung cancer."
3.	Infections 12/01/2004 - "Permissive HCMV infection consistently increased, albeit with different kinetics, the abundance of cleavage stimulation factor 64 (CstF-64) and PTB, and altered hypo-phosphorylated SF2 in different cell types. " 03/01/1996 - "By immunofluorescence, the homogeneous pattern of the 64-kDa CstF protein distribution became slightly clumped with infection, whereas the splicing small nuclear ribonucleoprotein particles were recognized into a highly punctate distribution away from the sites of virus transcription. " 03/01/1996 - "UV cross-linking experiments demonstrated that HSV infection caused enhanced binding of protein factors, including the 64-kDa component of cleavage stimulation factor (CstF), to poly(A) site RNAs from virus genes of all temporal classes and that this enhanced binding required expression of IE63. "
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/2022 - "Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating phosphatidylinositol 3'-kinase/protein kinase B/mammalian target of rapamycin pathway."
5.	Carcinoma (Carcinomatosis) 01/01/2022 - "Cleavage stimulation factor 2 (CSTF2), an important regulator of APA, has been reported to have a tumorigenic function in urothelial carcinoma of the bladder and lung cancers. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	TOR Serine-Threonine Kinases
3.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
4.	Proto-Oncogene Proteins c-akt (Protein Kinase B)
5.	Eosinophil-Derived Neurotoxin
6.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
7.	Small Nuclear Ribonucleoproteins (snRNP)
8.	RNA (Ribonucleic Acid)
9.	Proteins (Proteins, Gene)
10.	Poly A

Related Therapies and Procedures

1.	Therapeutics