Integrin alpha6beta4

This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.

Also Known As:

A9 Antigen; Integrin alpha(6),beta(4); Laminin-5 Receptor (alpha6beta4 Integrin); TSP-180; Tumor Specific Protein-180 Complex; alpha(6)beta(4) Epithelial Integrin; alpha(6)beta(4) Integrin; alpha6 beta4 Integrin; Antigen, A9; Integrin, alpha6 beta4; Tumor Specific Protein 180 Complex; alpha6beta4, Integrin; beta4 Integrin, alpha6

Networked: 225 relevant articles (1 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Integrins: 14304
        Cytoadhesin Receptors
        Integrin alpha6beta4: 225
        Laminin Receptors: 515
        Integrin alpha6beta4: 225

Experts

1.	Mercurio, Arthur M: 10 articles (02/2007 - 07/2002)
2.	Chung, Jun: 6 articles (10/2009 - 07/2002)
3.	Lipscomb, Elizabeth A: 6 articles (03/2006 - 07/2002)
4.	Bon, Giulia: 5 articles (07/2009 - 06/2006)
5.	Falcioni, Rita: 5 articles (07/2009 - 06/2006)
6.	Folgiero, Valentina: 5 articles (07/2009 - 06/2006)
7.	Sacchi, Ada: 5 articles (07/2009 - 06/2006)
8.	Gilcrease, Michael Z: 5 articles (05/2009 - 02/2004)
9.	Zhou, Xiao: 5 articles (05/2009 - 02/2004)
10.	Falzon, Miriam: 4 articles (07/2009 - 11/2006)

Related Diseases

1.	Blister (Bulla) 08/01/2008 - "Recent studies have shown that SM alkylation causes a significant reduction of laminin-5, disruption of alpha6beta4 integrin and decreases the expression of integrin alpha6 and beta4 subunits, therefore, leads to destabilization of dermal-epidermal attachments and potentiates vesication. "
2.	Neoplasms (Cancer) 10/01/2009 - "These studies define a novel mechanism by which integrin alpha6beta4 promotes cancer cell motility and invasion, and provides insight into how S100A4 expression is regulated in cancer cells." 01/01/1996 - "Several histopathological studies have established a correlation between alpha 6 beta 4 integrin expression and tumor progression. " 10/01/2009 - "Roles of laminin-332 and alpha6beta4 integrin in tumor progression." 10/01/2009 - "Integrin alpha6beta4 is linked to cancer cell motility and invasion in aggressive and metastatic cancer cells. " 07/15/2009 - "Increased expression of alpha(6)beta(4) integrin in several epithelial cancers promotes tumor progression; however, the mechanism underlying its transcriptional regulation remains unclear. "
3.	Carcinoma (Carcinomatosis) 03/01/2004 - "To study the expression of integrin alpha 6 beta 4 in human laryngeal carcinoma cell lines Hep-2 and AMC-HN8. " 12/26/1997 - "These studies define a mechanism by which the alpha6beta4 integrin promotes carcinoma invasion and invoke a novel function for PI3K signaling." 02/15/2007 - "The integrin alpha(6)beta(4) has been shown to facilitate key functions of carcinoma cells, including their ability to migrate, invade, and evade apoptosis. " 07/01/2006 - "Although much is known about the signaling potential of the alpha6beta4 integrin in carcinoma cells, the events that coordinate the disassembly of hemidesmosomes during differentiation and wound healing remain unclear. " 12/01/2005 - "The alpha6beta4 integrin has been widely implicated in carcinoma function in vitro; however, in vivo data are scarce. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2021 - "In this study, we aimed to analyze integrin alpha6beta4 expression on CTCs isolated from blood samples of patients with advanced breast cancer. " 02/01/2004 - "Recent studies suggest that alpha6beta4 integrin expression in invasive breast carcinomas may be a poor prognostic factor. " 01/16/2009 - "In summary, our data suggest that integrin alpha6beta4 confers a motile and invasive phenotype to breast carcinoma cells by regulating proinvasive and prometastatic gene expression." 10/15/2007 - "Our data emphasize the importance of the extracellular matrix stroma in tissue survival and suggest that alpha6beta4 integrin-dependent Rac stimulation of Pak1 could be an important mechanism mediating apoptosis-resistance in some breast tumors." 01/01/2007 - "Involvement of alpha6beta4 integrin in the mechanisms that regulate breast cancer progression."
5.	Epidermolysis bullosa with pyloric atresia 05/15/2000 - "Transient transfection studies of PA-JEB cells with beta4 revealed that the integrin alpha6beta4 becomes incorporated into the alpha3beta1-CD151 clusters where it induces the formation of hemidesmosomes. " 06/01/1997 - "Immunofluorescence studies of junctional epidermolysis bullosa with pyloric atresia (JEB-PA) have suggested abnormalities in the expression of the alpha6 beta4 integrin, an integral component of hemidesmosomes. " 12/01/2003 - "Genetic mutations in alpha6beta4 integrin cause junctional epidermolysis bullosa with pyloric atresia, a genodermatosis characterized by blistering of the skin and pyloric occlusion. " 02/01/2001 - "Junctional epidermolysis bullosa with pyloric atresia (JEB-PA) (MIM 226730) is an autosomal recessive disorder resulting from mutations in the genes encoding alpha 6 beta 4 integrin (ITGA6 and ITGB4). " 02/01/2001 - "Alpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia."

Related Drugs and Biologics

1.	Kalinin
2.	Integrin alpha6
3.	Integrins
4.	Antigens
5.	Blood Group Antigens (Blood Groups)
6.	Proteins (Proteins, Gene)
7.	Monoclonal Antibodies
8.	laminin 1
9.	Laminin Receptors
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Traction
4.	Immunotherapy