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Integrin alpha6beta1

A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Also Known As:
CD49f-CD29; Integrin alpha(6)beta(1); Integrin alpha6Abeta1; Integrin alpha6Bbeta1; Platelet Glycoprotein I'c-IIa; VLA-6; alpha 6 beta 1 Integrin; alpha6beta1 Integrin; CD49f CD29; Glycoprotein I'c-IIa, Platelet; I'c-IIa, Platelet Glycoprotein; Integrin, alpha6beta1; Platelet Glycoprotein I'c IIa; VLA 6; alpha6Abeta1, Integrin; alpha6Bbeta1, Integrin; alpha6beta1, Integrin
Networked: 78 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Nagle, Raymond B: 2 articles (08/2010 - 04/2004)
2. Cress, Anne E: 2 articles (08/2010 - 04/2004)
3. Ahmed, Nuzhat: 2 articles (05/2009 - 01/2005)
4. Li, Xiaowu: 2 articles (04/2009 - 11/2004)
5. Dong, Jiahong: 2 articles (04/2009 - 11/2004)
6. Lin, Chih-Yang: 1 article (05/2015)
7. Fong, Yi-Chin: 1 article (05/2015)
8. Hsu, Chin-Jung: 1 article (05/2015)
9. Tang, Chih-Hsin: 1 article (05/2015)
10. Tsai, Chun-Hao: 1 article (05/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Contusions
3. Carcinoma (Carcinomatosis)
4. Neoplasm Metastasis (Metastasis)
5. Melanoma (Melanoma, Malignant)

Related Drugs and Biologics

1. Laminin (Merosin)
2. Integrin alpha2beta1
3. Cadherins (E-Cadherin)
4. laminin 1
5. gamma Catenin (Plakoglobin)
6. Integrin alpha6
7. Integrin alpha6beta4
8. Calreticulin
9. GTP Phosphohydrolases (GTPases)
10. CD29 Antigens

Related Therapies and Procedures

1. Ligation