Poly(A)-Binding Protein II
A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
Also Known As:
PAB II; PAB2 Poly(A) Binding Protein; PABP2; Pabp2 Gene Product; Pabp2 Protein; Poly(A) Binding Protein II; Poly(A) Binding Protein, Nuclear 1
Networked: 60
relevant articles (0 outcomes,
1 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Rouleau, Guy A:
6 articles
(04/2019 - 04/2005)
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2. | Raz, Vered:
6 articles
(10/2016 - 05/2009)
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3. | Brais, Bernard:
5 articles
(07/2008 - 04/2005)
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4. | Dickson, George:
4 articles
(10/2016 - 04/2011)
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5. | Trollet, Capucine:
4 articles
(03/2015 - 04/2011)
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6. | van der Maarel, Silvère M:
4 articles
(04/2014 - 05/2009)
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7. | Brais, B:
4 articles
(10/2013 - 09/2000)
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8. | Rubinsztein, David C:
4 articles
(03/2011 - 04/2002)
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9. | Abu-Baker, Aida:
3 articles
(04/2019 - 09/2005)
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10. | Chartier, Aymeric:
3 articles
(03/2015 - 05/2009)
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