HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Poly(A)-Binding Protein II

A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
Also Known As:
PAB II; PAB2 Poly(A) Binding Protein; PABP2; Pabp2 Gene Product; Pabp2 Protein; Poly(A) Binding Protein II; Poly(A) Binding Protein, Nuclear 1
Networked: 50 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Rouleau, Guy A: 5 articles (07/2008 - 04/2005)
2. Brais, Bernard: 5 articles (07/2008 - 04/2005)
3. Trollet, Capucine: 4 articles (03/2015 - 01/2011)
4. Raz, Vered: 4 articles (04/2014 - 01/2011)
5. Brais, B: 4 articles (01/2013 - 09/2000)
6. Rubinsztein, David C: 4 articles (03/2011 - 04/2002)
7. Dickson, George: 3 articles (03/2015 - 01/2011)
8. van der Maarel, Silvère M: 3 articles (04/2014 - 10/2011)
9. Venema, Andrea: 3 articles (01/2013 - 01/2011)
10. Rouleau, G A: 3 articles (01/2013 - 09/2000)

Related Diseases

1. Oculopharyngeal Muscular Dystrophy
2. Muscular Diseases (Myopathy)
3. X-Linked Bulbo-Spinal Atrophy (Syndrome, Kennedy)
4. Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy)
5. Emery-Dreifuss Muscular Dystrophy (X-Linked Emery-Dreifuss Muscular Dystrophy)

Related Drugs and Biologics

1. polyalanine
2. Poly(A)-Binding Proteins (Poly(A)-Binding Protein)
3. Alanine (L-Alanine)
4. Nuclear Proteins (Protein, Nuclear)
5. Carrier Proteins (Binding Protein)
6. Lamin Type A (Lamin A)
7. Nuclear RNA
8. Sucrose (Saccharose)
9. Androgen Receptors (Androgen Receptor)
10. Mitochondrial DNA (mtDNA)