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Poly(A)-Binding Protein II

A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
Also Known As:
PAB II; PAB2 Poly(A) Binding Protein; PABP2; Pabp2 Gene Product; Pabp2 Protein; Poly(A) Binding Protein II; Poly(A) Binding Protein, Nuclear 1
Networked: 60 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Rouleau, Guy A: 6 articles (04/2019 - 04/2005)
2. Raz, Vered: 6 articles (10/2016 - 05/2009)
3. Brais, Bernard: 5 articles (07/2008 - 04/2005)
4. Dickson, George: 4 articles (10/2016 - 04/2011)
5. Trollet, Capucine: 4 articles (03/2015 - 04/2011)
6. van der Maarel, Silvère M: 4 articles (04/2014 - 05/2009)
7. Brais, B: 4 articles (10/2013 - 09/2000)
8. Rubinsztein, David C: 4 articles (03/2011 - 04/2002)
9. Abu-Baker, Aida: 3 articles (04/2019 - 09/2005)
10. Chartier, Aymeric: 3 articles (03/2015 - 05/2009)

Related Diseases

1. Oculopharyngeal Muscular Dystrophy
2. Muscular Diseases (Myopathy)
3. Late Onset Disorders
4. Frontotemporal Dementia (Semantic Dementia)
5. X-Linked Bulbo-Spinal Atrophy

Related Drugs and Biologics

1. polyalanine
2. Poly(A)-Binding Proteins (Poly(A)-Binding Protein)
3. Proteins (Proteins, Gene)
4. Alanine (L-Alanine)
5. Nuclear Proteins (Protein, Nuclear)
6. Carrier Proteins (Binding Protein)
7. Lamin Type A (Lamin A)
8. Protein Isoforms (Isoforms)
9. RNA-Binding Proteins (RNA-Binding Protein)
10. Nuclear RNA