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Integrin alpha4beta1 (VLA-4)

Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Also Known As:
VLA-4; CD49d-CD29; Integrin Heterodimer alpha4beta1; Integrin alpha(4)beta(1); Very Late Activation Antigen-4; Very Late Antigen-4; alpha4beta1 Integrin; Antigen-4, Very Late; Heterodimer alpha4beta1, Integrin; Integrin, alpha4beta1; Late Antigen-4, Very; Very Late Activation Antigen 4; Very Late Antigen 4; alpha4beta1, Integrin; alpha4beta1, Integrin Heterodimer
Networked: 461 relevant articles (26 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bendas, Gerd: 7 articles (12/2015 - 12/2008)
2. Schlesinger, Martin: 6 articles (12/2015 - 11/2009)
3. Lam, Kit S: 6 articles (05/2012 - 07/2006)
4. Liu, Ruiwu: 6 articles (05/2012 - 10/2004)
5. Okada, Hideho: 6 articles (10/2009 - 01/2007)
6. Anderson, Carolyn J: 5 articles (06/2015 - 05/2012)
7. Sasaki, Kotaro: 5 articles (10/2009 - 01/2007)
8. Storkus, Walter J: 5 articles (10/2009 - 01/2007)
9. Hagmann, William K: 5 articles (02/2007 - 01/2002)
10. Greil, Richard: 4 articles (08/2015 - 04/2009)

Related Diseases

1. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
2. Neoplasms (Cancer)
3. Inflammation
4. Melanoma (Melanoma, Malignant)
5. Multiple Sclerosis

Related Drugs and Biologics

1. Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
2. Antigens
3. natalizumab (Tysabri)
4. Monoclonal Antibodies
5. Lymphocyte Function-Associated Antigen-1 (LFA-1)
6. E-Selectin
7. Cytokines
8. Integrin alpha4
9. Antibodies
10. Apolipoproteins E (ApoE)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Ligation
3. Homologous Transplantation (Allograft)
4. Transplants (Transplant)
5. Immunomodulation