Integrin alpha Chains

The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
Also Known As:
Integrin alpha Subunits; Integrins, alpha; alpha Chains, Integrin; alpha Integrins
Networked: 86 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results


1. Haisma, Hidde J: 2 articles (05/2010 - 08/2002)
2. Vellon, Luciano: 2 articles (11/2007 - 05/2005)
3. Menendez, Javier A: 2 articles (11/2007 - 05/2005)
4. Lupu, Ruth: 2 articles (11/2007 - 05/2005)
5. Gladson, Candece L: 2 articles (10/2003 - 03/2003)
6. Liu, M: 2 articles (02/2000 - 01/2000)
7. Chen, Huilin: 1 article (04/2014)
8. Lijuan, Wang: 1 article (04/2014)
9. Zhou, Fating: 1 article (04/2014)
10. Liu, Xiaoheng: 1 article (04/2014)

Related Diseases

1. Neoplasms (Cancer)
2. Carcinoma (Carcinomatosis)
3. Ovarian Neoplasms (Ovarian Cancer)
12/01/2008 - "The effect of 17beta-estradiol on ovarian cancer cell proliferation, HSPG, the expressions of integrins alpha(upsilon)beta(3) and alpha(upsilon)beta(5), and adeno-associated viral vector (AAV)2-mediated gene transduction were determined. "
11/15/2007 - "Knocking down the expression of integrins alpha(5) and beta(1) in ovarian cancer cells interfered with endostatin-mediated inhibition of peritoneal seeding. "
03/01/2001 - "The expression of coxsackievirus-adenovirus receptor (CAR) and the integrins alpha(v)beta3 and alpha(v)beta5 was analyzed quantitatively (flow cytometry) and qualitatively (immunocytochemistry) in five human ovarian cancer cell lines (PEO1, PEO4, PEO14, SKOV-3, and OVCAR-3) and three control cell lines (293, HeLa, and CHO-K1). "
12/01/2008 - "In the present study, we found: (1) a variation in HSPG and the expressions of integrins alpha(upsilon)beta(3) and alpha(upsilon)beta(5) between OVCAR-3 and SKOV-3ip; (2) that 17beta-estradiol was shown to significantly stimulate cell proliferation and integrin beta(5) expression in certain ovarian cancer cell lines; and (3) integrintargeted A520/N584RGD-rAAV2, which has alternative interactivity with integrins and abrogates the binding capacity HSPG, showed much higher gene transduction efficiency in ovarian cancer cells than rAAV2 in the presence/absence of 17beta-estradiol. "
12/01/2008 - "The expression of heparin sulfate proteoglycan (HSPG) and integrins alpha(upsilon)beta(3) and alpha(upsilon)beta(5) were analyzed with flow cytometry on 2 human ovarian cancer cell lines (OVCAR-3 and SKOV-3ip). "
4. Colorectal Neoplasms (Colorectal Cancer)
5. Chondrosarcoma

Related Drugs and Biologics

1. Integrins
2. adenovirus receptor
3. Collagen
4. Laminin (Merosin)
5. Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
6. Collagen Type II (Type II Collagen)
7. Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
8. Vitronectin
9. Antibodies
10. Integrin alphaVbeta3

Related Therapies and Procedures

1. Angioplasty (Angioplasty, Transluminal)