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Polypyrimidine Tract-Binding Protein

A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
Also Known As:
PTB Protein; PTB Splicing Factor; p57 Cytoplasmic RNA-Binding Protein; pPTB; Polypyrimidine Tract Binding Protein; Splicing Factor, PTB; Tract-Binding Protein, Polypyrimidine; p57 Cytoplasmic RNA Binding Protein
Networked: 44 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Beck, W T: 3 articles (01/2014 - 07/2007)
2. He, X: 3 articles (01/2014 - 07/2007)
3. Cheung, Hannah C: 3 articles (11/2012 - 08/2006)
4. Cote, Gilbert J: 3 articles (11/2012 - 08/2006)
5. Ho, T-T: 2 articles (01/2014 - 01/2011)
6. Arslan, A D: 2 articles (01/2014 - 01/2011)
7. Krahe, Ralf: 2 articles (11/2012 - 08/2009)
8. Zhu, Wen: 2 articles (11/2012 - 08/2009)
9. Hai, Tao: 2 articles (11/2012 - 08/2009)
10. Coon, J S: 2 articles (01/2011 - 07/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Infection
3. Anoxia (Hypoxia)
4. Pulmonary Tuberculosis
5. Glioma (Gliomas)

Related Drugs and Biologics

1. Ovarian epithelial cancer
2. Messenger RNA (mRNA)
3. Heterogeneous-Nuclear Ribonucleoproteins (Informatin)
4. RNA-Binding Proteins (RNA-Binding Protein)
5. RNA (Ribonucleic Acid)
6. Carrier Proteins (Binding Protein)
7. Polypyrimidine Tract-Binding Protein
8. Small Interfering RNA (siRNA)
9. Heterogeneous-Nuclear Ribonucleoprotein L
10. Proteins (Proteins, Gene)