|1.||Roux, Philippe P: 4 articles (07/2014 - 09/2004)|
|2.||Taunton, Jack: 4 articles (11/2013 - 08/2008)|
|3.||Blenis, John: 3 articles (07/2014 - 09/2004)|
|4.||Ballif, Bryan A: 3 articles (07/2014 - 09/2004)|
|5.||Dunn, Sandra E: 3 articles (01/2014 - 01/2008)|
|6.||Berk, Bradford C: 3 articles (08/2011 - 01/2002)|
|7.||Abe, Jun-ichi: 3 articles (08/2008 - 01/2002)|
|8.||Appleton, Brent A: 2 articles (09/2015 - 05/2014)|
|9.||Jefferson, Anne B: 2 articles (09/2015 - 05/2014)|
|10.||Lan, Jiong: 2 articles (09/2015 - 05/2014)|
|1.||Melanoma (Melanoma, Malignant)
03/01/2015 - "Ribosomal protein S6 kinase, 90 kDa, polypeptide 1 (RSK1; official name RPS6KA1) was significantly hyperactivated in human melanoma lines and metastatic tissues derived from nodular compared with superficial spreading melanoma. "
05/02/2014 - "Using S100B overexpression and shRNA(S100B) knockdown studies in melanoma cell lines, elevated S100B was found to enhance cell viability and modulate MAPK signaling by binding directly to the p90 ribosomal S6 kinase (RSK). "
07/22/2014 - "RSK (p90 ribosomal S6 kinase) is a MAPK-activated protein kinase required for melanoma growth and proliferation, but relatively little is known about its exact function and the nature of its substrates. "
09/19/2013 - "Herein, we demonstrate that the MAPK-activated protein kinase RSK (p90 ribosomal S6 kinase) contributes to melanoma chemoresistance by altering their response to chemotherapeutic agents. "
05/02/2014 - "Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK."
09/21/2007 - "Taken together, these results suggest that activation of ERK1/2-p90(RSK) pathways following in vitro ischemia phosphorylates NHE1 and increases its activity, which subsequently contributes to neuronal damage."
05/11/2001 - "The results demonstrate that MAPK-dependent pathways including p90(rsk) and ERK1/2 and are important in regulating the Na(+)/H(+) exchanger and show their dramatic increase in activity toward the Na(+)/H(+) exchanger during ischemia and reperfusion of the myocardium. "
12/03/1999 - "Differential regulation of p90 ribosomal S6 kinase and big mitogen-activated protein kinase 1 by ischemia/reperfusion and oxidative stress in perfused guinea pig hearts."
11/01/2001 - "Recent studies suggest that ischemia activates Src and members of the mitogen-activated protein (MAP) kinase superfamily and their downstream effectors, including big MAP kinase 1 (BMK1) and p90 ribosomal S6 kinase (p90RSK). "
05/11/2001 - "p90(rsk) was identified as the 90-kDa protein kinase activated by ischemia and reperfusion while ERK1/2 was identified as accounting for some of the 44-kDa protein kinase phosphorylating the Na(+)/H(+) exchanger. "
08/01/2010 - "In this study, we determined whether Ser(703) and p90(rsk) activity are critical in activation of NHE1 by sustained intracellular acidosis. "
08/01/2010 - "We conclude that Ser(703) and p90(rsk) are not required for activation by sustained intracellular acidosis and that p90(rsk) phosphorylation of Ser(703) is independent of this type of activation."
11/01/2006 - "This revealed a time-dependent transient phosphorylation of both ERK1/2 and p90(RSK) by intracellular acidosis (intracellular pH approximately 6.6), with maximum activation occurring at 3 min and a return to basal levels by 20 min. When the degree of intracellular acidosis was varied from approximately 6.8 to approximately 6.5, maximum ERK1/2 phosphorylation was observed at an intracellular pH of 6.64. "
08/01/2010 - "The presence of a dominant-negative p90(rsk) kinase also did not prevent activation and phosphorylation of NHE1 by sustained intracellular acidosis in isolated cardiomyocytes. "
08/01/2010 - "Sustained intracellular acidosis activates the myocardial Na(+)/H(+) exchanger independent of amino acid Ser(703) and p90(rsk)."
05/01/2014 - "Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers."
02/01/2013 - "Evidence is also emerging that p90(RSK) may play a role in cancer cell signalling, although the role of p90(RSK) in regulating cancer cell metabolism is unclear. "
02/01/2013 - "Role of p90(RSK) in regulating the Crabtree effect: implications for cancer."
07/01/2012 - "Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers."
07/15/2007 - "Inappropriate activity of p90 ribosomal S6 kinase (RSK) has been implicated in various human cancers as well as other pathologies. "
|2.||Ribosomal Protein S6 Kinases (S6 Kinase)
|3.||Mitogen-Activated Protein Kinase 7
|4.||70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
|5.||Small Interfering RNA (siRNA)
|6.||Muscle Proteins (Muscle Protein)
|7.||Protein Kinases (Protein Kinase)
|8.||Mitogen-Activated Protein Kinase 3
|9.||90-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 90 kDa)