|1.||Meyuhas, Oded: 3 articles (03/2015 - 01/2009)|
|2.||Chen, Baosheng: 2 articles (02/2016 - 10/2012)|
|3.||Longtine, Mark S: 2 articles (02/2016 - 10/2012)|
|4.||Nelson, D Michael: 2 articles (02/2016 - 10/2012)|
|5.||Chen, Jianchun: 2 articles (03/2015 - 06/2006)|
|6.||Chen, Jian-Kang: 2 articles (03/2015 - 06/2006)|
|7.||Zhang, Wen: 2 articles (01/2015 - 11/2014)|
|8.||Liu, Dan: 2 articles (01/2015 - 11/2014)|
|9.||Gao, Jun: 2 articles (01/2015 - 11/2014)|
|10.||Li, Weimin: 2 articles (01/2015 - 11/2014)|
|1.||Parkinson Disease (Parkinson's Disease)
01/01/2010 - "We here studied, in the gold-standard non-human primate model of Parkinson's disease, the changes in PKA-dependent phosphorylation of DARPP-32 and GluR1 AMPA receptor, as well as in ERK and ribosomal protein S6 (S6) phosphorylation, associated to acute and chronic administration of L-DOPA. "
05/30/2014 - "Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers."
03/15/2013 - "Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer. "
06/01/2011 - "Phosphorylated ribosomal protein S6 was reduced in blood, normal rectal mucosa, and tumor biopsies at 24 h post-UCN-01. "
12/01/2006 - "We also assessed mTOR signaling in MCL tumors using immunohistochemical methods and a tissue microarray: 10 of 30 (33%) expressed Ser473p-AKT, 13 of 21 (62%) Ser2448p-mTOR, 22 of 22 (100%) p-p70S6K, and 5 of 20 (25%) p-ribosomal protein S6. "
09/08/2015 - "This reparative reaction is characterized by tumor neovascularization accompanied by infiltration of immune cells and carcinoma-associated fibroblasts that stain for phosphorylated ribosomal protein S6 (pS6), downstream the PI3K/Akt/mTOR pathway. "
10/01/2012 - "Exposure to rapamycin or hypoxia inactivated mammalian target of rapamycin, as reflected by reduced phosphorylation of ribosomal protein S6, indicating that mammalian target of rapamycin regulates autophagy in cultured cytotrophoblasts. "
06/01/2010 - "In contrast to the hypoxia-induced up-regulation of HIF-1 alpha, which involves decreased protein degradation, the up-regulation of HIF-1 alpha by the EP1 receptor was associated with the phosphorylation of ribosomal protein S6 (rpS6), suggesting activation of the ribosomal S6 kinases and increased translation. "
12/01/2009 - "Exposure to anoxia decreased 40S ribosomal protein S6 phosphorylation in heart and promoted eukaryotic initiation factor 4E-binding protein-1 (4E-BP1) dephosphorylation in red muscle, but surprisingly increased 4E-BP1 phosphorylation in white muscle. "
01/01/2009 - "However, certain proteins are believed to be preferentially translated during hypoxia via 5' terminal oligopyrimidine tract mechanisms with controversial discussion about the involvement of the mTOR-dependent ribosomal protein S6 (rpS6). "
04/29/2005 - "We found that phosphorylation of two molecules downstream to it, ribosomal p70 S6 kinase (S6K) and ribosomal protein S6, was markedly suppressed by hypoxia. "
03/01/2015 - "Here we generated congenic ribosomal protein S6 (rpS6) knock-in mice expressing nonphosphorylatable rpS6 and found that uninephrectomy-induced renal hypertrophy was significantly blunted in these knock-in mice. "
03/01/2015 - "Phosphorylation of ribosomal protein S6 mediates compensatory renal hypertrophy."
06/01/2014 - "Hypertrophy in the Mtm1 p.R69C gastrocnemius muscle was associated with increased levels of phosphorylated ribosomal protein S6. "
08/01/2013 - "Attenuation of hypertrophy results from a reduced protein synthesis capacity, as indicated by decreased phosphorylation of 4E-binding protein 1 and ribosomal protein S6. "
09/01/2009 - "Levels of phospho-Akt and phospho-ribosomal protein S6, which are critical for cell growth and hypertrophy, were markedly increased in the glomeruli of the Nx, while tempol treatment almost abolished the activation of these proteins. "
|5.||Hepatocellular Carcinoma (Hepatoma)
10/01/1986 - "The present experiments support the hypothesis that the regulation of protein synthesis is not tightly coupled to phosphorylation-dephosphorylation cycles, at least of ribosomal protein S6, in cells characterized by a rather uncontrolled growth such as the Yoshida (AH 130) rat ascites hepatoma. "
10/01/1988 - "Heat shock, protein synthesis and ribosomal protein S6 phosphorylation in vitro in Yoshida AH 130 ascites hepatoma cells."
01/25/1984 - "Tumor-promoting phorbol esters stimulate the phosphorylation of ribosomal protein S6 in quiescent Reuber H35 hepatoma cells."
03/10/1985 - "The relative abilities of insulin and the phorbol ester tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) to lead to the phosphorylation of ribosomal protein S6 in vivo were compared in a Reuber H35 hepatoma cell line shown previously to be highly responsive to these agents. "
01/01/1986 - "Other studies utilizing microinjection of antibodies to inhibit the receptor kinase have extended this conclusion to include a critical role for the receptor kinase in insulin's ability to stimulate ribosomal protein S6 phosphorylation in CHO cells, glycogen synthetase in hepatoma cells, glucose uptake in adipocytes (Morgan and Roth 1987), and frog oocyte maturation (Morgan et al. 1986). "
|1.||AMPA Receptors (AMPA Receptor)
|2.||Levodopa (L Dopa)
|5.||Peptide Initiation Factors (Initiation Factor)
|6.||Proteins (Proteins, Gene)
|7.||70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)
|9.||Eukaryotic Initiation Factor-4E
|10.||Protein-Tyrosine Kinases (Tyrosine Kinase)