Anterior Temporal Lobectomy

A neurosurgical procedure that removes the anterior TEMPORAL LOBE including the medial temporal structures of CEREBRAL CORTEX; AMYGDALA; HIPPOCAMPUS; and the adjacent PARAHIPPOCAMPAL GYRUS. This procedure is generally used for the treatment of intractable temporal epilepsy (EPILEPSY, TEMPORAL LOBE).

Also Known As:

Networked: 494 relevant articles (26 outcomes, 61 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Sperling, Michael R: 9 articles (01/2018 - 12/2005)
2.	Binder, Jeffrey R: 7 articles (01/2022 - 08/2005)
3.	Cole, Andrew J: 7 articles (01/2022 - 11/2014)
4.	Radhakrishnan, Kurupath: 7 articles (02/2020 - 01/2003)
5.	Sharan, Ashwini: 6 articles (01/2022 - 02/2011)
6.	Tripathi, Manjari: 6 articles (01/2020 - 03/2014)
7.	Knowlton, Robert C: 6 articles (01/2019 - 09/2003)
8.	Morioka, Takato: 5 articles (01/2022 - 09/2002)
9.	Swanson, Sara J: 5 articles (01/2022 - 12/2007)
10.	Tracy, Joseph I: 5 articles (01/2018 - 12/2005)

Related Diseases

1.	Temporal Lobe Epilepsy 01/01/2023 - "Anterior temporal lobectomy is the most effective treatment for intractable temporal lobe epilepsy (TLE). " 10/13/2021 - "Anterior temporal lobectomy (ATL) is the most effective treatment for drug-resistant mesial temporal lobe epilepsy. " 11/01/2006 - "Although anterior temporal lobectomy (ATL) is an effective treatment for many patients with medically refractory temporal lobe epilepsy (TLE), one risk associated with this procedure is postsurgical decline in memory. " 09/01/2015 - "Anterior Temporal Lobectomy (ATL) is the gold standard surgical treatment for refractory temporal lobe epilepsy (TLE), but it carries the risks associated with invasiveness, including cognitive and visual deficits and potential damage to eloquent structures. " 03/01/2021 - "One-third of the patients with drug-resistant temporal lobe epilepsy (TLE) have a normal MRI, but there are only a few studies regarding the surgical outcomes and the efficacy of anterior temporal lobectomy (ATL) in patients with nonlesional TLE. "
2.	Seizures (Absence Seizure) 02/20/2023 - "Anterior temporal lobectomy reduced epileptiform discharges and incidence of post-operative seizures as well as resulted in improved mood status and quality of life without causing significant changes in cognitive function." 01/01/2016 - "Anterior temporal lobectomy has been shown to be effective in controlling seizures but entails resecting anterior and lateral temporal lobe regions that are not necessarily included in the epileptogenic zone. " 05/01/2000 - "Anterior temporal lobectomy is an effective treatment for medically intractable temporal lobe seizures. " 12/01/2015 - "The purpose of this study was to investigate the efficacy of GKRS in patients with unilateral MTLE-HS who did not achieve seizure control or had recurrent seizures after anterior temporal lobectomy (ATL). " 10/01/1996 - "We assessed test-retest neuropsychological performance in patients with complex partial seizures to derive reliable change indices (RCIs) and regression-based norms for change, indices that may be helpful in assessing cognitive outcome after anterior temporal lobectomy. "
3.	Drug Resistant Epilepsy 01/01/2021 - "Anterior temporal lobectomy (ATL) is an effective treatment for drug-resistant epilepsy, and risk for post-surgical naming and verbal memory decline after dominant hemisphere ATL is well-established. " 04/01/2014 - "Anterior temporal lobectomy is an effective treatment for drug-resistant epilepsy of temporal origin, although new language impairment may develop after surgery. " 05/01/2004 - "The efficacy of an extratemporal focal cortical resection may be less effective than an anterior temporal lobectomy for intractable epilepsy. " 02/01/1999 - "The aim of this study was to examine factors precipitating patient readmission, following anterior temporal lobectomy (ATL) for refractory epilepsy. " 08/01/1998 - "Predictors of outcome of anterior temporal lobectomy for intractable epilepsy: a multivariate study."
4.	Epilepsy (Aura) 07/27/2019 - "After several years of poorly controlled seizure disorder, the patient underwent anterior temporal lobectomy and amygdalohippocampectomy, which proved beneficial for seizure control, as well as her neuropsychiatric symptoms. " 01/01/2021 - "The international league against epilepsy has proposed a new classification of HS based on pyramidal cell loss on different subfields to facilitate the study of HS pathology in patients after anterior temporal lobectomy (ATL), and the influence of these HS patterns on the prognosis of patients with TLE is contradictory. " 01/01/2019 - "We compared direct medical costs and indirect productivity costs associated with treatment with stereotactic radiosurgery (SRS) or anterior temporal lobectomy (ATL) in the ROSE (Radiosurgery or Open Surgery for Epilepsy) trial. " 09/01/2015 - "Anterior temporal lobectomy compared with laser thermal hippocampectomy for mesial temporal epilepsy: A threshold analysis study." 09/20/2006 - "In our study we analyzed retrospectively the possible electro-clinical, neuroimaging and surgery-related outcome predictors in 94 adult patients who had anterior temporal lobectomy (ATL) from the material of Epilepsy Centre of the National Institute of Psychiatry and Neurology, Budapest since the beginning of the surgery program in 1989 until 2001. "
5.	Hippocampal Sclerosis 01/01/2020 - "All had excellent outcome from anterior temporal lobectomy, and neuropathological study always showed characteristic hippocampal sclerosis (Hs). " 05/01/2005 - "Previous studies have shown that structural integrity (i.e., presence/absence of mesial temporal sclerosis (MTS)) of the left mesial temporal lobe is associated with verbal memory outcome following left anterior temporal lobectomy (ATL). " 10/01/2002 - "The aim of this study was to assess the eligibility to drive in patients with mesial temporal sclerosis who undergo anterior temporal lobectomy. " 07/01/2002 - "Further studies are ongoing to determine if these ERP abnormalities predict hippocampal sclerosis on histopathology, or outcome after anterior temporal lobectomy." 10/05/2023 - "We reviewed 18 right-handed patients with LMTLE who underwent anterior temporal lobectomy or selective amygdala hippocampectomy, 12 with (HS+) and 6 without hippocampal sclerosis (HS-). "

Related Drugs and Biologics

1.	Anticonvulsants (Antiepileptic Drugs)
2.	Amobarbital (Amsal)
3.	Hypnotics and Sedatives (Sedatives)
4.	Remifentanil (Ultiva)
5.	mahuang-tang
6.	Therapeutic Uses
7.	Cholinergic Agents (Cholinergics)
8.	N-Methylaspartate (NMDA)
9.	Prolactin
10.	Parvalbumins

Related Therapies and Procedures

1.	Operative Surgical Procedures
2.	Craniotomy
3.	Lasers (Laser)
4.	Patient Readmission
5.	Electrocoagulation (Electrocautery)