Glycogen Synthase Kinase 3

A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabolism. It regulates a diverse array of functions such as CELL DIVISION, microtubule function and APOPTOSIS.

Also Known As:

Networked: 810 relevant articles (36 outcomes, 93 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Avila, Jesús: 19 articles (01/2014 - 05/2003)
2.	Woodgett, James R: 15 articles (06/2022 - 04/2003)
3.	Eldar-Finkelman, Hagit: 15 articles (01/2021 - 03/2002)
4.	Hernández, Félix: 15 articles (09/2015 - 08/2003)
5.	Lucas, José J: 14 articles (01/2018 - 01/2004)
6.	McCubrey, James A: 13 articles (01/2022 - 05/2014)
7.	Martinez, Ana: 12 articles (01/2022 - 07/2002)
8.	Medina, Miguel: 11 articles (02/2019 - 09/2007)
9.	Gil, Carmen: 11 articles (01/2018 - 01/2011)
10.	Billadeau, Daniel D: 9 articles (11/2019 - 03/2005)

Related Diseases

1.	Insulin Resistance 10/01/2013 - "GSK-3 inhibition did not affect weight but improved insulin resistance, also on cellular level. " 01/01/2021 - "Oxidative stress associated with insulin resistance also dysregulates glycogen synthase kinase 3-β (GSK-3β), which leads to increased tau phosphorylation. " 01/06/2011 - "Administration of specific GSK-3 inhibitors to diabetic or obese rodent models improves glycaemic control and insulin sensitivity. " 09/01/2010 - "The evidence to date supports an important role of GSK-3 dysfunction in the multifactorial etiology of insulin resistance in skeletal muscle. " 01/01/2010 - "This insulin resistance in human islets is not present in rodent islets and may explain the differential requirement in human islets to inhibit GSK-3 to enhance these regenerative processes. "
2.	Neoplasms (Cancer) 01/01/2020 - "This review will focus on the effects of small molecule inhibitors and natural products on GSK-3 activity and provide examples where these compounds were effective in suppressing cancer growth." 11/01/2023 - "However, the connection between GSK-3 and immunoevasive contexture, including tumor budding (TB) has not been previously examined. " 11/01/2023 - "Glycogen synthase kinase 3 (GSK-3) has been proposed as a novel cancer target due to its regulating role in both tumor and immune cells. " 08/01/2023 - "Various researches have revealed that glycogen synthase kinase 3 (GSK-3) inhibitors can contain the growth of some cancers. " 06/29/2023 - "GSK-3 inhibitor elraglusib (9-ING-41) has shown promising preclinical and clinical antitumor activity across multiple tumor types. "
3.	Alzheimer Disease (Alzheimer's Disease) 09/02/2010 - "Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease." 11/01/2021 - "Screening of potential drug for Alzheimer's disease: a computational study with GSK-3 β inhibition through virtual screening, docking, and molecular dynamics simulation." 12/01/2019 - "Numerous studies have highlighted the implications of the glycogen synthase kinase 3 (GSK-3) in several processes associated with Alzheimer's disease (AD). " 01/01/2005 - "The study demonstrated that overactivation of GSK-3 induced hyperphosphorylation of neurofilament and suggested that in vitro overactivation of GSK-3 resulted in neurofilament hyperphosphorylation and this may be the underlying mechanism for Alzheimer's disease." 01/01/2023 - "Further evaluation of 34 and 40 in vivo demonstrated that these compounds are orally bioavailable, brain-penetrant GSK-3 inhibitors that lowered levels of phosphorylated tau in a triple-transgenic mouse Alzheimer's disease model."
4.	Bipolar Disorder (Manic Depressive Psychosis) 08/01/2020 - "Moreover, the present work also suggests a therapeutic potential for selective GSK-3 β inhibitors in the management of bipolar disorders patients." 08/01/2020 - "Moreover, the present work also suggests a therapeutic potential for selective GSK-3 β inhibitors in the management of bipolar disorders patients. " 08/01/2020 - "Moreover, the present work also suggests a therapeutic potential for selective GSK-3 β inhibitors in the management of bipolar disorders patients. " 08/01/2020 - "Moreover, the present work also suggests a therapeutic potential for selective GSK-3 β inhibitors in the management of bipolar disorders patients. " 08/01/2020 - "Moreover, the present work also suggests a therapeutic potential for selective GSK-3 β inhibitors in the management of bipolar disorders patients. "
5.	Schizophrenia (Dementia Praecox) 06/01/2004 - "This may indicate that investigation of the genetics of GSK-3 beta regulation holds promise for understanding some of the biochemical underpinnings of schizophrenia." 04/01/2008 - "Previous studies have suggested that GSK-3 beta might act as a potential candidate locus for schizophrenia susceptibility. " 01/01/2005 - "Taken together, these studies suggest that low GSK-3 in postmortem brain of schizophrenic patients is a late consequence of perinatal neurodevelopmental insult in schizophrenia. " 06/01/2013 - "In this article, I will focus on the converging evidence supporting a prominent role for Wnt and glycogen synthase kinase 3 (GSK3) signaling in the biological bases of schizophrenia. " 03/01/2011 - "Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3."

Related Drugs and Biologics

1.	Lithium
2.	Proteins (Proteins, Gene)
3.	Glycogen Synthase (Synthase I)
4.	Glucose (Dextrose)
5.	Enzymes
6.	Phosphotransferases (Kinase)
7.	SB 216763
8.	Insulin (Novolin)
9.	N- (4- methoxybenzyl)- N'- (5- nitro- 1,3- thiazol- 2- yl)urea
10.	Serine (L-Serine)

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Immunotherapy
4.	Radiotherapy
5.	Drug Therapy (Chemotherapy)