alpha-Crystallin B Chain

One of the alpha crystallin subunits. In addition to being expressed in the lens (LENS, CRYSTALLINE), alpha-crystallin B chain has been found in a variety of tissues such as HEART; BRAIN; MUSCLE; and KIDNEY. Accumulation of the protein in the brain is associated with NEURODEGENERATIVE DISEASES such as CREUTZFELDT-JAKOB SYNDROME and ALEXANDER DISEASE.

Also Known As:

Networked: 189 relevant articles (4 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	van Noort, Johannes M: 10 articles (01/2019 - 08/2003)
2.	Bsibsi, Malika: 5 articles (01/2015 - 10/2012)
3.	Amor, Sandra: 5 articles (08/2014 - 03/2007)
4.	Verbeek, Richard: 4 articles (01/2015 - 08/2003)
5.	Gerritsen, Wouter H: 4 articles (08/2014 - 10/2012)
6.	van Noort, J M: 4 articles (06/2006 - 04/2000)
7.	Nacken, Peter J: 3 articles (01/2015 - 01/2013)
8.	Holtman, Inge R: 3 articles (08/2014 - 01/2013)
9.	Wawrousek, Eric F: 3 articles (03/2007 - 01/2003)
10.	Sanbe, Atsushi: 3 articles (01/2007 - 07/2004)

Related Diseases

1.	Squamous Cell Carcinoma of Head and Neck 07/01/2005 - "Univariate survival analysis identified lack of alpha B-crystallin staining as an independent prognostic marker for disease-free interval (P < 0.001) and overall survival (P < 0.002) of HNSCC patients over the 5-year observation period. " 01/01/2008 - "The aim of the study was to investigate the expression of alpha-B-crystallin and p53 in head and neck squamous cell carcinoma (HNSCC). " 09/01/2015 - "Alpha-B-crystallin expression in human laryngeal squamous cell carcinoma tissues." 12/12/2012 - "Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma." 01/01/2008 - "Alpha-B-crystallin was not a prognostic marker for HNSCC."
2.	Pick Disease of the Brain (Pick's Disease) 10/01/1995 - "The remaining brains have frontal lobe degeneration: the use of alpha B-crystallin immunostaining, on these, to detect ballooned neurons may help to define two groups of patients, one of which we believe may represent a variant of Pick's disease. " 08/01/1992 - "alpha B Crystallin was expressed by the majority of ballooned neurons of Pick's disease and CJD, but not by those of the other disorders. " 06/01/1995 - "We studied the distribution of alpha B-crystallin-positive degenerating neurons in cases with progressive supranuclear palsy, and compared them with those in Pick's disease. " 08/01/1992 - "Ubiquitin and srp 27 expression was also restricted to abnormal neurons of Pick's disease and CJD, but the proportion of stained cells was less than that expressing alpha B-crystallin. " 01/01/2008 - "Pick disease (PiD) is a frontotemporal dementia characterized by frontal and temporal atrophy, neuronal loss, gliosis, ballooned neurons that are positive for alpha-B crystallin and neurofilament, and the presence of tau- and ubiquitin-positive Pick bodies. "
3.	Cardiomegaly (Heart Hypertrophy) 12/05/2008 - "Alpha B-crystallin suppresses pressure overload cardiac hypertrophy." 01/01/2023 - "Compared with R120G mice, S14D/S14D::R120G mice showed significantly greater myocardial proteasome activities, lower levels of total and K48-linked ubiquitin conjugates, and of aberrant CryAB (alpha B-crystallin) protein aggregates, less fetal gene reactivation, and cardiac hypertrophy, and delays in cardiac malfunction. "
4.	Ocular Hypertension (Glaucoma, Suspect) 07/05/2012 - "Alpha B-crystallin improved survival of retinal ganglion cells in a rat model of acute ocular hypertension."
5.	Ischemia 11/15/1999 - "In the present study, we have demonstrated that transient focal ischemia in rats dramatically induced HSP27 but not alpha B-crystallin (alphaBC), both of which are members of sHSPs, in reactive astrocytes. " 03/01/1999 - "Ischemia-induced myofibrillar targeting of alpha B-crystallin probably requires additional structural and posttranslational modifications of myofibrillar components in juxtaposition to I-bands." 03/01/1999 - "The time course of translocation of alpha B-crystallin to myofibrils during ischemia correlated with phosphorylation of approximately 20% of the entire alpha B-crystallin pool. " 03/01/1999 - "During reperfusion after 25 min of ischemia, alpha B-crystallin disappeared rapidly from myofibrils: whereas reperfusion after irreversibly damaging ischemia (60 min) resulted in dissociation of alpha B-crystallin only from those myofibrils and myocardiocytes that were still able to contract, and alpha B-crystallin remained bound to the overstretched, damaged myofibrils no longer capable of contraction. " 03/01/1999 - "Irreversibly damaging ischemia (60 min) was accompanied by extreme stretching of the majority of myofibrils, and by concomitant extension of alpha B-crystallin localization from the Z-line area to I-bands. "

Related Drugs and Biologics

1.	Ubiquitin
2.	Protein Aggregates
3.	Proteasome Endopeptidase Complex (Proteasome)
4.	Heat-Shock Proteins (Heat-Shock Protein)
5.	Proteins (Proteins, Gene)
6.	Small Heat-Shock Proteins
7.	Adenosine Triphosphate (ATP)
8.	Matrix Metalloproteinases (MMPs)
9.	Matrix Metalloproteinase 1 (Interstitial Collagenase)
10.	Proliferating Cell Nuclear Antigen (PCNA)

Related Therapies and Procedures

1.	Lenses
2.	Drug Therapy (Chemotherapy)