alpha-Crystallin A Chain

08/18/2021 - "Polymorphisms in alpha A crystallin (CRYAA) gene have been implicated in susceptibility to cataracts, but some published studies have reported inconclusive results. "
01/01/2023 - "Association between single nucleotide polymorphisms in exon 3 of the alpha-A-crystallin gene and susceptibility to age-related cataract."
07/29/2017 - "Association of alpha A-crystallin polymorphisms with susceptibility to nuclear age-related cataract in a Han Chinese population."
05/20/2017 - "A silent mutation in human alpha-A crystallin gene in patients with age-related nuclear or cortical cataract."
01/01/2011 - "Haplotype analysis traced the disease gene to an 18.47 cM region bounded by D21S263 and D21S266 on chromosome21q22.11-q22.3. Direct sequencing of the candidate alpha A crystallin (CRYAA) gene revealed a c.347G>A transition in exon 3 of CRYAA that co-segregated with the cataract in the family members and was not observed in 100 control patients. "

02/01/1996 - "Mice with the alpha A-crystallin promoter exhibit bilateral lens tumors and PNET of the midbrain. "
11/01/1987 - "A fusion gene consisting of this alpha A-crystallin promoter sequence and the T-antigen gene of SV40 produced a lens tumor in transgenic mice. "
03/27/1987 - "Transgenic mice carrying a hybrid gene comprising the murine alpha A-crystallin promoter (-366 to +46) fused to the coding sequence of the SV40 T antigens developed lens tumors, which obliterated the eye cavity and even invaded neighboring tissue, thus establishing that the lens is not refractive to oncogenesis. "
06/01/1991 - "Accumulation and spatial location of aldose reductase mRNA in a lens tumor of an alpha A-crystallin/SV40 T antigen transgenic mouse line."

03/27/1987 - "Transgenic mice carrying a hybrid gene comprising the murine alpha A-crystallin promoter (-366 to +46) fused to the coding sequence of the SV40 T antigens developed lens tumors, which obliterated the eye cavity and even invaded neighboring tissue, thus establishing that the lens is not refractive to oncogenesis. "

02/01/1996 - "Mice with the alpha A-crystallin promoter exhibit bilateral lens tumors and PNET of the midbrain. "

02/01/1995 - "Stimulation of alpha A-crystallin promoter activity via 8-bromo-cAMP, forskolin, or human T-cell leukemia virus type I Tax1 in transfections and reduction of activity of this site in cell-free transcription tests by competition with the somatostatin CRE supported the idea that DE1 is a functional CRE. "