|1.||Reddy, G Bhanuprakash: 8 articles (01/2008 - 07/2002)|
|2.||Andley, Usha P: 5 articles (01/2016 - 10/2003)|
|3.||Reddy, P Yadagiri: 5 articles (01/2008 - 07/2002)|
|4.||Kumar, P Anil: 5 articles (12/2007 - 04/2004)|
|5.||Kumar, M Satish: 4 articles (12/2007 - 04/2004)|
|6.||Wilkinson, Katalin A: 4 articles (07/2007 - 02/2005)|
|7.||Wilkinson, Robert J: 4 articles (07/2007 - 02/2005)|
|8.||Harding, John J: 4 articles (05/2007 - 06/2002)|
|9.||Yan, Hong: 4 articles (05/2007 - 12/2003)|
|10.||MacRae, Thomas H: 4 articles (10/2003 - 02/2002)|
07/01/2009 - "In this study, we investigated the antiglycating potential of cumin in vitro and its ability to modulate the chaperone-like activity of alpha-crystallin vis-à-vis the progression of diabetic cataract in vivo. "
12/01/2008 - "alpha-Crystallin index measurements may be useful in identifying patients at high risk for cataracts and as an outcome variable in clinical lens studies. "
10/01/2003 - "This study has identified the first dominant cataract mutation in CRYAA located outside the phylogenetically conserved 'alpha-crystallin core domain' of the sHSP family."
07/01/1998 - "The study of the binding of alpha-crystallin to membranes is potentially important for understanding the function of alpha-crystallin in the ocular lens and the formation of cataracts. "
01/01/2016 - "Autophagy and UPR in alpha-crystallin mutant knock-in mouse models of hereditary cataracts."
10/15/2005 - "The neuroprotective efficacy of alpha-crystallin against acute inflammation in mice."
03/01/2006 - "This study was designed to investigate the prophylactic effect of alpha-crystallin, a major chaperone lens protein comprising of alpha-A and alpha-B subunits in inflammation induced mice. "
06/10/2005 - "The in vitro study has shown that alpha-crystallin treatment not only suppresses the increase in LPO levels but also inhibits the lipid breakdown resulting from autooxidation in mouse cerebral cortex homogenate, and strongly suggests that alpha-crystallin therapy may serve as a potent pharmacological agent in systemic inflammation."
06/10/2005 - "This study was designed to investigate the prophylactic effect of alpha-crystallin, a major chaperone lens protein comprising of alpha-A and alpha-B subunits in inflammation-induced mice. "
03/01/2006 - "Mice were divided into three groups (n=6 in each), control, inflammation and alpha-crystallin treated. "
04/01/2001 - "Study of the chaperoning mechanism of bovine lens alpha-crystallin, a member of the alpha-small heat shock superfamily."
08/06/2010 - "The lens also contains high concentrations of the small heat shock chaperone alpha-crystallin, which suppresses aggregation of model substrates in vitro. "
01/01/2003 - "The brine shrimp, Artemia franciscana, produces a small heat shock/alpha-crystallin protein termed p26, found in embryos undergoing encystment, diapause, and metabolic arrest. "
02/01/2002 - "Oviparously developing embryos of the brine shrimp, Artemia franciscana, synthesize abundant quantities of a small heat shock/alpha-crystallin protein, termed p26. "
02/01/2002 - "Functional analysis of a small heat shock/alpha-crystallin protein from Artemia franciscana. "
01/01/1999 - "tuberculosis is dominated by increased synthesis of the alpha-crystallin homolog sHsp16, previously implicated in stationary-phase processes and found in this study to be a major M. "
09/01/2001 - "The fact that antibody to Acr is found in a high percentage of tuberculosis patients suggests that the hypoxic shiftdown of tubercle bacilli to the NRP state that occurs in vitro, resulting in production of the alpha-crystallin protein, occurs in vivo as well. "
03/01/2002 - "tuberculosis genes acr/hspX/Rv2031c (alpha-crystallin homolog) and Rv2032/acg (acr-coregulated gene) by using a promoter-GFP fusion assay in Mycobacterium bovis BCG. "
06/19/2001 - "tuberculosis alpha-crystallin (acr) gene is powerfully and rapidly induced at reduced oxygen tensions, providing us with a means to identify regulators of the hypoxic response. "
06/15/2007 - "tuberculosis antigens (early secreted antigenic target 6, culture filtrate protein 10, TB10.3, and alpha-crystallin 2) were less affected, indicating a high prevalence of latent tuberculosis (approximately 80%) in both HIV-negative and HIV-positive subject groups. "
|5.||Neurodegenerative Diseases (Neurodegenerative Disease)
01/01/2016 - "Overall this review points out the novel roles that chaperones such as alpha-crystallins can play outside of the classical protein folding pathways, and their potential in the development of new therapies for the treatment of neuroinflammatory/neurodegenerative diseases. "
10/10/2008 - "Thus, our study ascribes a novel functional role to alpha-crystallins in Cu(2+) homeostasis and helps in understanding their protective role in neurodegenerative diseases and cataract."
02/01/2011 - "New focus on alpha-crystallins in retinal neurodegenerative diseases."
01/01/2007 - "Although tau aggregation and alphaB-crystallin expression have been shown to increase in neurodegenerative diseases, surprisingly tau expression increases in the alpha-crystallin knockout lenses, suggesting that alphaA- and alphaB-crystallins are potentially important regulators of tau expression in lens."
09/26/2008 - "Small heat shock proteins (sHSPs) and the related alpha-crystallins are ubiquitous chaperones linked to neurodegenerative diseases, myopathies, and cataract. "
|4.||Amyloid (Amyloid Fibrils)
|6.||Molecular Chaperones (Chaperone, Molecular)
|3.||Drug Therapy (Chemotherapy)
|4.||Fluid Therapy (Oral Rehydration Therapy)