Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)

An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.

Also Known As:

Networked: 950 relevant articles (51 outcomes, 178 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Holmskov, Uffe: 39 articles (01/2019 - 09/2002)
2.	Kishore, Uday: 30 articles (01/2021 - 05/2003)
3.	Madan, Taruna: 28 articles (06/2022 - 09/2002)
4.	Crouch, Erika C: 24 articles (11/2013 - 06/2002)
5.	Beers, Michael F: 22 articles (11/2019 - 01/2003)
6.	Hartshorn, Kevan L: 20 articles (01/2020 - 06/2002)
7.	Hawgood, Samuel: 19 articles (01/2016 - 03/2002)
8.	Sorensen, Grith L: 17 articles (01/2022 - 06/2006)
9.	Madsen, Jens: 17 articles (10/2021 - 08/2003)
10.	Gow, Andrew J: 17 articles (11/2019 - 03/2004)

Related Diseases

1.	Inflammation (Inflammations) 07/01/2001 - "These data suggest that clearance of SP-D into lung tissue is increased during inflammation and that tissue-associated neutrophils significantly contribute to this process." 01/01/2019 - "Further studies are warranted to support that increased SP-D expression in the human colonic epithelium is protective against intestinal inflammation." 12/01/2015 - "Protective effects of surfactant protein D treatment in 1,3-β-glucan-modulated allergic inflammation." 07/01/2001 - "Enhanced clearance of surfactant protein D during LPS-induced acute inflammation in rat lung." 02/01/2001 - "SP-D(-/-) mice cleared these bacteria as efficiently as wild-type mice; however, clearance of viral pathogens was deficient in SP-D(-/-) mice and associated with increased inflammation. "
2.	Infections 10/28/2005 - "Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood." 06/01/2009 - "Here we developed a novel null-infection model to test the hypothesis that SP-D contributes to the clearance of viable Pseudomonas aeruginosa from the healthy ocular surface in vivo. " 03/01/2003 - "SP-A and SP-D coordinate the innate and adaptive immune response in the lung and convey protection against infection in amniotic fluid and vernix caseosa. " 01/01/2021 - "The current study aimed to examine the potential of a recombinant fragment of human SP-D (rfhSP-D) as an inhibitor of replication and infection of SARS-CoV-2. " 12/01/2013 - "In this study, we analyzed whether plasma SP-D concentrations reflect rejection or infection of the lung allograft. "
3.	Hypersensitivity (Allergy) 12/15/2017 - "Recombinant Fragment of Human Surfactant Protein D: A Hierarchical Regulator of Pulmonary Hypersensitivity." 05/01/2008 - "We aimed to determine the effect of SP-D deficiency on murine and human airway allergy. " 02/01/2001 - "These results clearly implicate pulmonary SP-A and SP-D in the modulation of allergic reactions." 12/01/2015 - "OVA-induced mucous cell metaplasia was increased in Sftpd(-/-) mice, supporting previously reported protective effects of endogenous SP-D in allergy. " 09/01/2005 - "SP-A and SP-D have been shown to be involved in viral neutralization, clearance of bacteria, fungi, and apoptotic and necrotic cells, down-regulation of allergic reaction, and resolution of inflammation. "
4.	Pneumonia (Pneumonitis) 06/05/2021 - "The study results suggest that SP-D is a useful marker for differentiating b-pneumonia and d-pneumonia." 01/01/2020 - "It was displayed in our study that SP-D was greatly decreased in pneumonia mice models. " 01/01/2022 - "Serum SP-D level has a predictive value for the detection of community-acquired pneumonia severity in children. " 01/01/2022 - "SP-D was significantly higher among children with severe pneumonia, as determined by WHO, PRESS, and PIROm (P = 0.001). " 01/01/2022 - "The SP-D level was significantly lower in patients with simple pneumonia than in patients with severe pneumonia (P < 0.001). "
5.	Acute Lung Injury 01/01/2016 - "These results suggest that the measurement of SP-D levels is an additional tool for monitoring acute lung injuries in rats." 06/15/2014 - "KGF treatment increases BAL surfactant protein D, a marker of type II alveolar epithelial cell proliferation in a human model of acute lung injury. " 04/01/2002 - "Finally to evaluate acute lung injury, we instilled rats with HCl; SP-D was increased at 4 h after instillation. " 07/01/2012 - "Thus this is the first study to demonstrate the molecular mechanisms, in which SP-D expression under acute and persistent hypoxia in acute lung injury might be differentially modulated by stabilized HIF-1α expression and de novo twist expression." 07/01/2012 - "Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury."

Related Drugs and Biologics

1.	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)
2.	Proteins (Proteins, Gene)
3.	Allergens
4.	Biomarkers (Surrogate Marker)
5.	Surface-Active Agents (Surfactants)
6.	Collectins (Collectin)
7.	Lectins
8.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
9.	C-Reactive Protein
10.	Cytokines

Related Therapies and Procedures

1.	Therapeutics
2.	Intranasal Administration
3.	Intravenous Injections
4.	Drug Therapy (Chemotherapy)
5.	Artificial Respiration (Mechanical Ventilation)