Galectin 4 (LGALS4)

A galectin found in the small and large intestine and the stomach. It occurs as a homodimer with two 36-kDa subunits and is localized to sites of cell adhesion where it may play role in assembly of ADHERENS JUNCTIONS.

Also Known As:

LGALS4; Galectin-4; Lactose-Binding Lectin, L-36; Lactose-Binding Protein, L-36; Lectin, Galactoside-Binding, Soluble, 4 Protein; L-36 Lactose-Binding Lectin; L-36 Lactose-Binding Protein; Lactose Binding Lectin, L 36; Lactose Binding Protein, L 36; Lectin, L-36 Lactose-Binding

Networked: 104 relevant articles (1 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Lectins: 6782
    - Galectins: 1124
      - Galectin 4: 104
        human LGALS4 protein

Experts

1.	Gabius, Hans-Joachim: 9 articles (02/2022 - 04/2003)
2.	André, Sabine: 5 articles (12/2016 - 04/2003)
3.	Kaltner, Herbert: 4 articles (06/2022 - 04/2003)
4.	Leffler, Hakon: 4 articles (02/2016 - 01/2004)
5.	Kopitz, Jürgen: 3 articles (06/2022 - 06/2012)
6.	Michalak, Malwina: 3 articles (06/2022 - 12/2016)
7.	Solmi, Rossella: 3 articles (07/2020 - 10/2004)
8.	Belo, Ana I: 3 articles (11/2017 - 01/2013)
9.	Decaestecker, Christine: 3 articles (07/2014 - 04/2003)
10.	Mizoguchi, Atsushi: 3 articles (09/2008 - 06/2004)

Related Diseases

1.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/09/2008 - "Conclusively, after defining its biological role, we propose Galectin-4 is a novel anti-inflammatory agent that could be therapeutically effective in diseases with a disturbed T cell expansion and apoptosis such as inflammatory bowel disease."
2.	Neoplasms (Cancer) 07/01/2023 - "A meta-analysis and comprehensive mechanistic studies, pertaining to different aspects of galectin-4 biology, could give statistically driven correlations, elucidating multifaceted role of galectin-4 in cancer." 07/01/2023 - "Exclusion criteria were studies that investigated other disease conditions, interventions unrelated to cancer or galectin-4 and bias outcome. " 07/01/2023 - "Inclusion criteria for study selection were availability of full-text articles, articles in English language and articles relevant to current topic, that is, galectin-4 and cancer. " 07/01/2023 - "A differential expression of galectin-4 was observed in different cancer stages/ and types. " 07/01/2023 - "Multifaceted role of galectin-4 in cancer: A systematic review."
3.	Adenocarcinoma 09/01/2017 - "We found an inverse correlation between galectin-4 and TTF-1 expressions in acinar adenocarcinoma, and this phenomenon was also found to be present in metastatic sites. " 07/30/2014 - "Galectin-4 (Gal-4) has been recently identified as a pivotal factor in the migratory capabilities of a set of defined pancreatic ductal adenocarcinoma (PDAC) cell lines using zebrafish as a model system. " 01/01/2007 - "Through differential screening, virtual reverse northern hybridization and quantitative real-time reverse-transcription-polymerase chain reaction (qRT-PCR) we selected five genes (TncRNA, OCIAD2, ANXA2, TMED4 and LGALS4) that were expressed at significantly higher levels in invasive adenocarcinoma mixed subtype with BAC than in BAC. " 09/01/2017 - "In the present study, 208 cases of acinar adenocarcinoma of the lung and 36 cases with distant metastatic lesions of lung adenocarcinoma were immunohistochemically examined for expression of galectin-4 and TTF-1 to elucidate their correlation with clinicopathological factors. " 01/01/2019 - "Galectin 4 is a biomarker for early recurrence and death after surgical resection for pancreatic ductal adenocarcinoma."
4.	Stomach Neoplasms (Stomach Cancer) 08/01/2023 - "Our previous study demonstrated that galectin-4 participates in the peritoneal dissemination of poorly differentiated gastric cancer cells. " 01/01/2023 - "Our data highlight the diagnostic and therapeutic potential of galectin-4 in the peritoneal dissemination of gastric cancer." 01/01/2023 - "We clarified the role of galectin-4 in the development of peritoneal dissemination of poorly differentiated gastric cancer cells. " 01/01/2022 - "Validation of the RIPK genes through GEPIA identified 8 genes (NRP1, MNX1, SSRP1, PRDX2, PLRG1, LGALS4, SNX5 and FXYD3) which are highly expressed in stomach cancer were significantly down-regulated in PRU treated samples. " 01/01/2023 - "Suppression of galectin-4 expression reduced proliferation and peritoneal metastasis of malignant gastric cancer cells. "
5.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2019 - "This study was performed to validate the prognostic value of galectin 4 in a larger cohort of pancreatic cancer patients undergoing surgical resection. " 01/01/2023 - "Extracellular Galectin 4 Drives Immune Evasion and Promotes T-cell Apoptosis in Pancreatic Cancer." 01/01/2019 - "Galectin 4 expression was evaluated by tissue microarrays and immunohistochemistry in 140 patients with surgically resected pancreatic cancer. " 08/01/2017 - "High galectin-4 expressing colon, normal pancreatic and pancreatic cancer-derived cell lines (n = 5) were incubated with peripheral blood cells from different donors. " 01/01/2013 - "Galectin-4 Reduces Migration and Metastasis Formation of Pancreatic Cancer Cells."

Related Drugs and Biologics

1.	Anti-Inflammatory Agents (Anti-Inflammatories)
2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	Polysaccharides (Glycans)
5.	Galectin 1 (LGALS1)
6.	Galectin 3 (LGALS3)
7.	Carrier Proteins (Binding Protein)
8.	Glycosyltransferases
9.	Glycoproteins (Glycoprotein)
10.	Interleukin-27 (Interleukin 27)

Related Therapies and Procedures

1.	Castration