Adenylate Cyclase Toxin

One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.

Also Known As:

AC Toxin, Bordetella; Ac-Hly, Bordetella; Adenylate Cyclase-Haemolysin Bifunctional Protein, B. pertussis; Adenylate Cyclase-Hemolysin; Bordetella Adenylate Cyclase Toxin; Bordetella pertussis Adenylate Cyclase Toxin; Cyclolysin; Pertussis Adenylate Cyclase-Haemolysin Bifunctional Protein; cyaA Gene Product, Bordetella; cyaA Protein, Bordetella; cyaA Toxin; Ac Hly, Bordetella; Adenylate Cyclase Haemolysin Bifunctional Protein, B. pertussis; Adenylate Cyclase Hemolysin; Bordetella AC Toxin; Bordetella Ac-Hly; Bordetella cyaA Protein; Cyclase Toxin, Adenylate; Cyclase-Hemolysin, Adenylate; Pertussis Adenylate Cyclase Haemolysin Bifunctional Protein; Protein, Bordetella cyaA; Toxin, Adenylate Cyclase; Toxin, Bordetella AC; Toxin, cyaA

Networked: 124 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sebo, Peter: 21 articles (01/2022 - 10/2003)
2.	Ladant, Daniel: 20 articles (01/2021 - 10/2003)
3.	Chenal, Alexandre: 16 articles (01/2020 - 06/2006)
4.	Osicka, Radim: 14 articles (10/2021 - 10/2003)
5.	Ostolaza, Helena: 11 articles (12/2021 - 06/2004)
6.	Masin, Jiri: 11 articles (10/2021 - 06/2004)
7.	Martín, César: 10 articles (12/2021 - 06/2004)
8.	Uribe, Kepa B: 7 articles (12/2021 - 02/2011)
9.	Bumba, Ladislav: 7 articles (01/2021 - 01/2014)
10.	Davi, Marilyne: 7 articles (01/2019 - 03/2010)

Related Diseases

1.	Infections 10/01/1990 - "In contrast, adenylate cyclase toxin mutant BP348 was rapidly cleared from the lungs, with no viable bacteria remaining 10 days postchallenge, suggesting that the adenylate cyclase toxin is a colonization factor required for the bacteria to initiate infection." 01/01/2017 - "Adenylate cyclase toxin (ACT) is a critical factor in establishing infection with B. " 01/01/2017 - "Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis." 05/01/2013 - "Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection." 06/06/2011 - "The Bordetella pertussis adenylate cyclase toxin (CyaA) assists infection by potently suppressing the host immune response. "
2.	Whooping Cough (Pertussis) 01/01/2021 - "The adenylate cyclase toxin, CyaA, is one of the key virulent factors produced by Bordetella pertussis, the causative agent of whooping cough. " 01/01/2019 - "This is the first report that terminally differentiated tissue-resident macrophage cells can be dedifferentiated in vitro The results suggest that blocking of monocyte-to-macrophage transition and/or dedifferentiation of the sentinel cells of innate immunity through cAMP-elevating toxin action may represent a novel immune evasion strategy of bacterial pathogens.IMPORTANCE Macrophages are key sentinel cells of the immune system, and, as such, they are targeted by the toxins produced by the pertussis agent Bordetella pertussis The adenylate cyclase toxin (CyaA) mediates immune evasion of B. " 11/01/2018 - "The adenylate cyclase toxin (CyaA) is a multi-domain protein secreted by Bordetella pertussis, the causative agent of whooping cough. " 07/01/2018 - "The adenylate cyclase toxin (CyaA) plays an essential role in the early stages of respiratory tract colonization by Bordetella pertussis, the causative agent of whooping cough. " 11/24/2017 - "These findings document the complexity of subversive physiological manipulation of myeloid phagocytes by the CyaA toxin, serving in immune evasion of the pertussis agent."
3.	Hemolysis 10/01/2001 - "Translocation-specific conformation of adenylate cyclase toxin from Bordetella pertussis inhibits toxin-mediated hemolysis." 10/01/1995 - "When bacteria grown at 37 degrees C were shifted to 22 degrees C, transcription from the adenylate cyclase toxin haemolysis promoter (PAC) was repressed after 30 min, while transcription from the bvg (P1) and filamentous haemagglutinin (PFHA) promoters was repressed after 2 h. " 06/08/1992 - "Enzymatic activity of adenylate cyclase toxin from Bordetella pertussis is not required for hemolysis." 02/01/2006 - "Adenylate cyclase toxin (CyaA) of Bordetella pertussis penetrates the membrane of eukaryotic cells, producing high levels of intracellular cAMP, as well as hemolysis that results from the formation of cation-selective toxin channels in the membrane. "
4.	Edema (Dropsy) 01/01/2019 - "The adenylate cyclase toxin (CyaA) of Bordetella pertussis and the edema toxin (ET) of Bacillus anthracis are both calmodulin-activated toxins with adenylyl cyclase activity that invade host cells and massively increase the cellular concentrations of a key second messenger molecule, 3',5'-cyclic adenosine monophosphate (cAMP). " 06/01/2012 - "The ability of Bordetella pertussis adenylate cyclase toxin to translocate its adenylate cyclase domain across the host cell membrane, as well as the pathways of intracellular trafficking of Bacillus anthracis lethal and edema toxins, Shigella dysenteriae shiga toxin or Escherichia coli shiga-like toxin, have been repeatedly exploited for the delivery of antigenic epitopes into host cells and for stimulation of antigen-specific T cell responses. "
5.	Cough 01/01/2020 - "Bordetella pertussis, the causative agent of whopping cough, produces an adenylate cyclase toxin (CyaA) that plays a key role in the host colonization by targeting innate immune cells which express CD11b/CD18, the cellular receptor of CyaA. " 01/01/2019 - "By using the rat model, we demonstrated that adenylate cyclase toxin, dermonecrotic toxin, and the type III secretion system are not involved in cough production, but BspR/BtrA (different names for the same protein), an anti-σ factor, regulates the production of unknown factor(s) to cause coughing. "

Related Drugs and Biologics

1.	Virulence Factors (Pathogenicity Factors)
2.	Pertussis Toxin
3.	Hemolysin Proteins (Hemolysins)
4.	Adenylyl Cyclases (Adenylyl Cyclase)
5.	Hemagglutinins (Hemagglutinin)
6.	Proteins (Proteins, Gene)
7.	Antigens
8.	Vaccines
9.	Cytotoxins (Cytolysins)
10.	Integrins

Related Therapies and Procedures

1.	Microspheres (Microsphere)