Fumonisins

A group of MYCOTOXINS found in CORN contaminated with FUSARIUM fungus. They are chains of about 20 carbons with acidic ester, acetylamino and sometimes other substituents. They inhibit ceramide synthetase conversion of SPHINGOLIPIDS to CERAMIDES.

Also Known As:

Networked: 334 relevant articles (3 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Riley, Ronald T: 10 articles (05/2022 - 04/2004)
2.	Shephard, G S: 8 articles (11/2010 - 05/2000)
3.	Voss, Kenneth A: 7 articles (03/2018 - 08/2003)
4.	Gelderblom, Wentzel C A: 6 articles (04/2018 - 04/2004)
5.	Marasas, W F O: 6 articles (06/2012 - 04/2006)
6.	van der Westhuizen, L: 6 articles (11/2010 - 05/2001)
7.	Riley, R T: 6 articles (01/2009 - 07/2000)
8.	Voss, K A: 6 articles (01/2009 - 07/2000)
9.	Marasas, Walter F O: 6 articles (11/2005 - 08/2003)
10.	Wu, Felicia: 5 articles (05/2022 - 06/2008)

Related Diseases

1.	Infections 02/01/2008 - "Thirty individually caged crossbred adult rabbit bucks averaging 1.36 +/- 0.01 kg (about 22-24-week-old) were randomly allotted to three treatment diets comprising a control diet (containing 0.35 +/- 0.02 mg fumonisin/kg) and two test diets containing 12.30 +/- 0.16 and 24.56 +/- 0.14 mg fumonisin/kg, constituting treatments 1 (low infection), 2 (medium infection) and 3 (high infection), respectively, in a five-week feeding trial. " 03/01/2007 - "Two of these inbred lines, 02C14624 and 02C14585, had fumonisin levels <5.0 μg/g across years in trials where disease was initiated from both natural infection and artificial inoculation. " 06/01/2005 - "This study revealed that the continuous presence of fumonisins in the diets of quail chicks might increase the susceptibility to or the severity of Salmonella Gallinarum infection." 10/01/2023 - "verticillioides infection and kernel fumonisin production." 10/01/2023 - "Roles of Ear Injury, Infestation, and Vector Activity by Ostrinia furnacalis (Asian Corn Borer) and Conogethes punctiferalis (Yellow Peach Moth) in Fusarium verticillioides Infection and Kernel Fumonisin Level."
2.	Body Weight (Weight, Body) 04/11/2003 - "In adult male rats, dietary exposure to fumonisin induces a significant increase in both SA concentrations and SA/SO ratio in kidney, but not in liver and brain, as well as a significant reduction of body weight gain. " 05/01/2022 - "In the present study, male Wistar rats were fed between 21 and 63 days of age with diets that contained fumonisins B1+B2 at 0, 1, and 4 mg/kg. The following variables were assessed: food consumption, growth, body weight gain, and blood parameters. " 01/01/2020 - "None of the broiler chicken showed clinical symptoms of fumonisins (FBs) or HFB1 toxicity during the trial, nor was an aberration in body weight observed between the animals fed the FBs-contaminated diet and those fed the control diet. " 02/01/2023 - "However, total fumonisins did not show significant variation across AEZs, but all positive samples exceeded 150 µg/kg, required for tolerable daily intake of 1.0 µg/kg body weight per day, established by the European Food Safety Authority Panel on Contaminants in the Food Chain. " 09/08/2022 - "Maternal fumonisin intoxication caused a decrease in the body weight at birth and an increase in the heart, liver, kidney, lungs, ovaries, and testes weights. "
3.	Hepatocellular Carcinoma (Hepatoma) 08/11/2000 - "Hepatoma cell lines, on the other hand, undergo cell division in culture and are sensitive to the toxic effects of fumonisins. " 11/01/1991 - "Fumonisins B1 and B2, produced by Fusarium moniliforme Sheldon induce toxic hepatitis and hepatomas in rats and leukoencephalomalacia in horses. " 02/01/2019 - "Fumonisin B1-induced oxidative stress triggers Nrf2-mediated antioxidant response in human hepatocellular carcinoma (HepG2) cells." 05/16/2014 - "Fumonisin B₁ modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b." 08/01/2001 - "Aflatoxins and fumonisins in corn from the high-incidence area for human hepatocellular carcinoma in Guangxi, China."
4.	Liver Diseases (Liver Disease) 04/01/2018 - "Populations consuming aflatoxin (AF) and fumonisin (FN)-contaminated foods may be at increased risk for hepatocellular carcinoma (HCC) and developmental disorders; consequently, development of intervention strategies to reduce AF/FN-induced liver disease and adverse health effects in humans could be very useful. " 12/30/2002 - "Fumonisins cause a wide spectrum of disease (liver and renal toxicity and carcinogenesis, neurotoxicity, induction of pulmonary edema, and others), and most-possibly all-of the pathophysiologic effects of fumonisins are attributable to disruption of the sphingolipid metabolism. "
5.	Neoplasms (Cancer) 07/15/1999 - "Ecological studies have linked consumption of fumonisin contaminated maize with oesophageal cancer in human populations in South Africa and China. " 01/01/1997 - "Fumonisins are currently the focus of a FDA long-term tumor study. " 01/01/2013 - "Negative consequences of consumption of fumonisin-contaminated food by humans include an increased risk of oesophagus cancer and decreased body mass growth. " 03/01/2011 - "The consumption of maize highly contaminated with carcinogenic fumonisins has been linked to high oesophageal cancer rates. " 11/01/2010 - "In the Centane magisterial area of South Africa, high rates of oesophageal cancer have been associated with home-grown maize contaminated with fumonisins. "

Related Drugs and Biologics

1.	Aflatoxins
2.	Volatile Oils (Essential Oils)
3.	Fumonisins
4.	Mycotoxins
5.	Enzymes
6.	Sphingolipids
7.	safingol (sphinganine)
8.	Folic Acid (Vitamin M)
9.	Biomarkers (Surrogate Marker)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Euthanasia (Mercy Killing)
2.	Oral Administration