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Calreticulin

A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Also Known As:
55-kDa High-Affinity Calcium Binding Protein; CAB-63; CBP3 (Liver); Calcium-Binding Protein-3; Calregulin; ERp60; HACBP; cC1qR Protein; 55 kDa High Affinity Calcium Binding Protein; Calcium Binding Protein 3
Networked: 1198 relevant articles (26 outcomes, 104 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Kroemer, Guido: 33 articles (01/2022 - 01/2007)
2. Michalak, Marek: 21 articles (07/2022 - 12/2003)
3. Zitvogel, Laurence: 21 articles (12/2021 - 01/2007)
4. Kepp, Oliver: 18 articles (01/2022 - 02/2009)
5. Ferreira, Arturo: 16 articles (01/2020 - 03/2004)
6. Wu, T-C: 15 articles (01/2017 - 08/2004)
7. Constantinescu, Stefan N: 14 articles (12/2021 - 12/2015)
8. Plo, Isabelle: 14 articles (12/2021 - 09/2014)
9. Vainchenker, William: 14 articles (12/2021 - 09/2014)
10. Guglielmelli, Paola: 12 articles (01/2021 - 03/2014)

Related Diseases

1. Neoplasms (Cancer)
2. Necrosis
3. Breast Neoplasms (Breast Cancer)
4. Leukemia
5. Melanoma (Melanoma, Malignant)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Vaccines
3. DNA Vaccines
4. Antigens
5. Adenosine Triphosphate (ATP)
6. Peptides (Polypeptides)
7. Janus Kinase 2
8. Heat-Shock Proteins (Heat-Shock Protein)
9. HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)
10. Ligands

Related Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Drug Therapy (Chemotherapy)
4. Lasers (Laser)
5. Photothermal Therapy