Ciguatera Poisoning (Ciguatera)

Poisoning caused by ingestion of SEAFOOD containing microgram levels of CIGUATOXINS. The poisoning is characterized by gastrointestinal, neurological and cardiovascular disturbances.

Also Known As:

Networked: 355 relevant articles (11 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Disease Progression
2.	Neuroblastoma
3.	Poisoning
4.	Foodborne Diseases
5.	Shellfish Poisoning

Experts

1.	Chinain, Mireille: 27 articles (05/2022 - 09/2005)
2.	Hirama, Masahiro: 23 articles (01/2019 - 12/2002)
3.	Lewis, Richard J: 20 articles (07/2021 - 06/2002)
4.	Darius, Hélène Taiana: 16 articles (05/2022 - 06/2009)
5.	Hess, Philipp: 14 articles (05/2022 - 01/2010)
6.	Viallon, Jérôme: 10 articles (05/2022 - 07/2016)
7.	Botana, Luis M: 10 articles (02/2022 - 01/2009)
8.	Laurent, Dominique: 10 articles (01/2018 - 01/2005)
9.	Robertson, Alison: 9 articles (05/2022 - 01/2016)
10.	Vale, Carmen: 9 articles (02/2022 - 07/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ciguatera Poisoning:

1.	Mannitol (Osmitrol)FDA LinkGeneric 05/13/1988 - "Twenty-four patients with acute ciguatera fish poisoning were treated with intravenous mannitol, and each patient's condition improved dramatically. " 01/01/1992 - "Intravenous mannitol was introduced as an effective treatment for ciguatera in 1988. " 03/01/2005 - "It is suggested that intravenous mannitol may prove to be a useful treatment for mild to moderate ciguatera poisoning, and for patients who present late for treatment." 01/01/1992 - "[Evaluation of the efficacy of mannitol in the treatment of ciguatera in French Polynesia]." 11/01/2017 - "Comparative trials of mannitol: Evidence supporting mannitol for ciguatera fish poisoning includes four uncontrolled case series, one prospective, unblinded comparative trial and several case reports. "
2.	Amitriptyline (Elavil)FDA LinkGeneric 07/03/1986 - "Symptomatic improvement with amitriptyline in ciguatera fish poisoning." 06/23/1984 - "Amitriptyline and ciguatera." 01/01/1987 - "Treatment of ciguatera fish poisoning with amitriptyline and nifedipine."
3.	Excitatory Amino Acid Transporter 2IBA 06/01/2013 - "The activation of astroglia was further indicated by activation of the gap junction protein connexin 43 and upregulation of excitatory amino acid transporter 2 expression suggesting that glutamate was normally rapidly cleared from the synaptic cleft during acute ciguatera poisoning. "
4.	Glutamic Acid (Glutamate)FDA Link 06/01/2013 - "The activation of astroglia was further indicated by activation of the gap junction protein connexin 43 and upregulation of excitatory amino acid transporter 2 expression suggesting that glutamate was normally rapidly cleared from the synaptic cleft during acute ciguatera poisoning. "
5.	Connexin 43 (Connexin43)IBA 06/01/2013 - "The activation of astroglia was further indicated by activation of the gap junction protein connexin 43 and upregulation of excitatory amino acid transporter 2 expression suggesting that glutamate was normally rapidly cleared from the synaptic cleft during acute ciguatera poisoning. "
6.	ConnexinsIBA 06/01/2013 - "The activation of astroglia was further indicated by activation of the gap junction protein connexin 43 and upregulation of excitatory amino acid transporter 2 expression suggesting that glutamate was normally rapidly cleared from the synaptic cleft during acute ciguatera poisoning. "
7.	PutrescineIBA 10/15/2017 - "Two new compounds heliotropiumides A (1) and B (2), phenolamides each with an uncommon carbamoyl putrescine moiety, were isolated from the seeds of a naturalized Hawaiian higher plant, Heliotropium foertherianum Diane & Hilger in the borage family, which is widely used for the treatment of ciguatera fish poisoning. "
8.	Analgesics (Analgesic Drugs)IBA 10/01/2013 - "These findings highlight the need for suitable animal models to guide the empiric choice of analgesics, and suggest that lamotrigine and flupirtine could be potentially useful for the treatment of ciguatera."
9.	Lamotrigine (Lamictal)FDA LinkGeneric 10/01/2013 - "These findings highlight the need for suitable animal models to guide the empiric choice of analgesics, and suggest that lamotrigine and flupirtine could be potentially useful for the treatment of ciguatera."
10.	flupirtineIBA 10/01/2013 - "These findings highlight the need for suitable animal models to guide the empiric choice of analgesics, and suggest that lamotrigine and flupirtine could be potentially useful for the treatment of ciguatera."

Therapies and Procedures

1.	Therapeutics 08/30/2017 - "Given the contribution of CGRP to nociceptive and itch sensing pathways, our findings contribute to a better understanding of sensory symptoms of acute and chronic ciguatera that may help in the identification of potential therapeutics." 06/01/2009 - "At present, most diagnosed cases of ciguatera are treated with symptomatic and supportive remedies, and no specific therapy has been devised. " 07/17/1989 - "We report here the results of a pilot study to assess the efficacy of mannitol therapy in ciguatera poisoning. " 03/26/2002 - "Ciguatera fish poisoning: a double-blind randomized trial of mannitol therapy." 06/15/2016 - "These findings underline the usefulness of this novel in vitro model for studying the cellular and molecular mechanisms of the neuro-cutaneous effects of ciguatoxins, which may assist with identifying potential therapeutics for ciguatera fish poisoning. "
2.	Intravenous Administration 03/01/1995 - "Although no definitive therapy is known, the most promising treatment for ciguatera is intravenous administration of mannitol. "
3.	Baths 01/01/1993 - "Studies on ciguatera victims in which their hands were immersed in water baths ranging from 0 degree C to 50 degrees C, suggest the paradoxical sensory discomfort experienced is, most likely, a result of an exaggerated and intense nerve depolarization occurring in peripheral small A-delta myelinated and in particular, C-polymodal nociceptor fibers. "
4.	Palliative Care (Palliative Therapy) 01/01/2005 - "No specific antidote exists to date, and it is only by symptomatic or palliative treatments that ciguatera is currently treated."
5.	Microspheres (Microsphere) 01/01/1992 - "The presence or absence of ciguatera-related toxins is determined by binding the toxins to a membrane attached to a plastic strip and exposing the toxin ladened membrane to a monoclonal antibody-colored latex bead complex which has a high specificity for ciguatera-related toxins. "