Limonins

A group of degraded TRITERPENES in which the four terminal carbons of the C17 side chain have been removed, and the remaining portion often forming C17 furans.

Also Known As:

Tetranortriterpene, Limonoid; Limonoid; Limonoid Tetranortriterpene; Limonoid Tetranortriterpenes; Limonoids; Tetranortriterpene; Tetranortriterpenes; Tetranortriterpenoid; Tetranortriterpenoids

Networked: 143 relevant articles (7 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Limonins: 143
        nimbolide: 94
        limonin: 86
        azadirachtin: 46
        gedunin: 36
        obacunone: 28
        nomilin: 18
        nimbin: 11
        epoxyazadiradione: 9
        azadiradione: 7
        swietenine: 7
        cedrelone: 4
        limonexic acid: 4
        28-deoxonimbolide: 3
        deoxygedunin: 3
        deoxylimonin: 3
        mexicanolide: 3
        1-cinnamoyl-3,11-dihydroxymeliacarpin: 2
        28-deacetylsendanin: 2
        anthothecol: 2
        azadirone: 2
        12-O-acetylazedarachin B: 1
        azadirachtin B: 1
        erythrocarpine E: 1
        havanensin: 1
        ichangensin: 1
        isoobacunoic acid: 1
        methyl kulonate: 1
        niloticin: 1
        prieurianin: 1
        rubescin E: 1
        walsuronoid B: 1
        xyloccensin E: 1
        xyloccensin I: 1
        xyloccensin K: 1
        xylogranatin C: 1
        xylomexicanin C: 1
        1-methacrylyl-3-acetyl-11-methoxymeliacarpinin
        1-methylpropanoyl-3-acetyl-11-methoxymeliacarpinin
        1-O-acetylkhayanolide A
        1-O-tigloyl-1-O-deacetylnimbolinin B
        11-hydroxyswietephragmin B
        11-oxo-7alpha-obacunol
        11-oxo-7alpha-obacunyl acetate
        11beta-hydroxy-7alpha-obacunyl acetate
        11beta-hydroxycneorin G
        12-acetoxyharrisonin
        15-acetyltrichagmalin E
        17-epi 12-dehydroxyheudebolin
        1beta,2beta;21,23-diepoxy-7alpha-hydroxy-24,25,26,27-tetranor-apotirucalla-14,20,22-trien-3-one
        2,3-dihydronimbolide
        2-hydroxyseneganolide
        21,24,25,26,27-pentanor-15,22-oxo-7,23-dihydroxy-apotirucalla(eupha)-1-en-3-one
        23-oxo-21 -hydroxy-21,23-dihydroevodol
        3,6-dihydroxydihydrocarapin
        3-alpha-acetoxydihydrodeoxygedunin
        3-de(2-methylbutanoyl)-3-propanoylcipadesin
        3-deacetyl-17-defurano-17,28-dioxosalannin
        3-deacetyl-28-oxosalanninolide
        3-deacetyl-28-oxosalannolactone
        3-deacetylamoorastatin
        3-deacetylkhivorin
        3-deoxymethylnimbidate
        3beta-O-tigloylmelianol
        5alpha,6beta,8alpha,12alpha- tetrahydro-28-norisotoonafolin
        6,11-diacetoxygedunin
        6-acetoxyhumilinolide C
        6-deacetylnimbin
        6-deacetylseverinolide
        6-hydroxygedunin
        6-hydroxysandoricin
        7-desacetoxy-6,7-dehydrogedunin
        7alpha-dihydroxyl-12alpha-acetoxyl-14,20,22-trien-21,23-epoxy-6,28-epoxy 24,25,26,27-tetranorapotirucalla-(apoeupha)-1alpha-tigloyloxy-3alpha
        9-amoorastatin
        achook
        andirolide W
        andirolide X
        andirolide Y
        aphanamixoid A
        aphanamixoid B
        aphanamolide A
        aphanamolide B
        augustineolide
        azadirachta R
        azadirachtin H
        azadiraindin E
        azadiraindin F
        azadiraindin G
        cedrelanolide
        cedrellin
        ceramicine B
        chisomicine A
        chisomicine B
        chisomicine C
        chukrasone A
        chukrasone B
        chukvelutilide H
        chukvelutin A
        chukvelutin B
        chukvelutin C
        cineracipadesin G

Experts

1.	Patil, Bhimanagouda S: 17 articles (02/2021 - 04/2005)
2.	Nagini, Siddavaram: 7 articles (01/2022 - 05/2009)
3.	Jayaprakasha, Guddadarangavvanahally K: 7 articles (03/2015 - 03/2007)
4.	Jayaprakasha, G K: 6 articles (02/2021 - 01/2010)
5.	Kim, Jinhee: 5 articles (10/2014 - 11/2011)
6.	Hao, Xiaojiang: 4 articles (06/2022 - 01/2021)
7.	Gupta, Subash C: 4 articles (10/2020 - 01/2011)
8.	Akihisa, Toshihiro: 4 articles (10/2016 - 04/2011)
9.	Nair, Mangalam S: 3 articles (10/2020 - 08/2013)
10.	Kowshik, Jaganathan: 3 articles (10/2018 - 02/2016)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2017 - "Previous studies have shown that limonoid compounds possess anti-cancer potential, although the molecular mechanism of this activity remains elusive. " 03/01/2007 - "Citrus limonoids have shown to inhibit the growth of cancer in colon, lung, mouth, stomach and breast in animal and cell culture studies. " 10/01/2005 - "Among the limonoids isolated in the present study, compounds 3 and 4 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1 and 2 showed weak cytotoxicity." 08/17/2023 - "Neem limonoids are value additions to the armamentarium of natural compounds that target aberrant oncogenic signaling to inhibit cancer development and progression." 06/01/2022 - "Therefore, limonoid derivatives might be promising sources of natural bioactive metabolites against cancer."
2.	Colonic Neoplasms (Colon Cancer) 04/30/2013 - "These results suggest that consumption of curcumin and limonoids together may offer greater protection against colon cancer." 04/30/2013 - "For the first time, this study provides compelling evidence of the pharmacodynamic additive effect of limonoids and curcumin in inhibiting human colon cancer cells. " 04/30/2013 - "Citrus limonoids and curcumin additively inhibit human colon cancer cells." 01/14/2011 - "Here we investigated whether nimbolide, a limonoid, could sensitize human colon cancer cells to TRAIL. " 06/01/2010 - "This experiment investigated the effects of four citrus flavonoids and one limonoid mixture at the promotion stage of chemically induced colon cancer in rats. "
3.	Inflammation (Inflammations) 01/01/2020 - "Then, the investigation of anti-inflammation therapeutic limonoids from this plant was developed in the present study. " 01/01/2016 - "Limonoids found in citrus fruits decreased cell proliferation and inflammation in animal studies. " 11/01/2021 - "Additionally, SD mice fed with limonoids + Spm or limonoids alone had less inflammation in hypothalamic tissues and displayed a greater number of neurons. " 01/01/2020 - "The root barks of perennial herb Dictamnus dasycarpus (Cortex Dictamni) were reported to be rich in anti-inflammation activity constituents, limonoids. " 08/17/2023 - "There is overwhelming evidence to indicate that neem limonoids exert anticancer effects by preventing the acquisition of hallmark traits of cancer, such as cell proliferation, apoptosis evasion, inflammation, invasion, angiogenesis, and drug resistance. "
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2021 - "Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr." 06/14/2019 - "Both the limonoids were non-toxic to HEK293T cells thus, substantiating limonoids as a potential lead in overcoming Alzheimer's disease." 12/27/2021 - "In this study, we observed disease progression, changes in the gut microbiota, and interactions among the brain, liver, pancreas, and intestine in a mouse model of Alzheimer's disease (AD), in addition to attempting to inhibit disease progression through the dietary supplementation of L-arginine and limonoids. " 09/27/2018 - "In this present review we explored the potential efficacy of phytochemicals such as epigallocatechin-3-galate, berberin, curcumin, resveratrol, quercetin and limonoids against the most common NDs, including Alzheimer's disease (AD) and Parkinson's disease (PD). " 01/01/2022 - "A wide range of plant extracts and phytochemicals reported to possess the therapeutic potential to Alzheimer's disease includes curcumin, resveratrol, epigallocatechin-3-gallate, morin, delphinidins, quercetin, luteolin, oleocanthal, and other phytochemicals such as huperzine A, limonoids, and azaphilones. "
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/22/2020 - "To identify natural products having efficacy against inflammatory bowel disease (IBD), we isolated 13 limonoids including a new compound, methyl sudachinoid A, from the seeds of Citrus junos and investigated their anti-inflammatory effects by assessing the expression of pro-inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 mouse macrophages and HT-29 human colon epithelial cells. "

Related Drugs and Biologics

1.	Curcumin
2.	nimbolide
3.	gedunin
4.	limonin
5.	Antioxidants
6.	Phytochemicals
7.	Quercetin
8.	Lipopolysaccharides
9.	Resveratrol
10.	Cytokines

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention