|1.||Walseth, Timothy F: 7 articles (09/2008 - 03/2003)|
|2.||Kannan, Mathur S: 7 articles (09/2008 - 03/2003)|
|3.||Panettieri, Reynold A: 5 articles (05/2005 - 03/2003)|
|4.||Deshpande, Deepak A: 5 articles (05/2005 - 03/2003)|
|5.||Lund, Frances E: 4 articles (09/2013 - 02/2004)|
|6.||De Flora, Antonio: 3 articles (06/2009 - 10/2006)|
|7.||Zocchi, Elena: 3 articles (06/2009 - 10/2006)|
|8.||Bruzzone, Santina: 3 articles (06/2009 - 10/2006)|
|9.||Usai, Cesare: 3 articles (06/2009 - 10/2006)|
|10.||Peers, Chris: 3 articles (01/2006 - 12/2005)|
|1.||Asthma (Bronchial Asthma)
07/01/2004 - "The present study was aimed at determining the effect of interleukin (IL)-13, a cytokine implicated in the pathogenesis of asthma, on CD38/cADPR signaling and to ascertain the contribution of CD38/cADPR signaling to IL-13-induced airway hyperresponsiveness. "
05/01/2005 - "In this review, we describe the basic mechanisms underlying the dynamics of calcium regulation and the role of CD38/cADPR, a novel pathway, in the context of airway smooth muscle function and its contribution to airway diseases such as asthma."
06/01/2004 - "In addition, cADPr-mediated calcium release appears to play an important role in the "non-specific" increased ASM responsiveness to contractile agonists in cytokine-treated cells, a characteristic finding of asthma. "
06/01/2007 - "In human airway smooth muscle (HASM) cells, the expression of CD38, which synthesizes the calcium-mobilizing molecule cyclic ADP-ribose, is augmented by TNF-alpha, a cytokine implicated in asthma. "
08/01/2004 - "Recent evidence suggests that CD38, an ectoenzyme that converts NAD(+) to cyclic ADP-ribose (cADPr), may play a role in cytokine-induced airway smooth muscle (ASM) cell hyper-responsiveness, a key feature associated with chronic asthma. "
03/01/2003 - "In this study, we investigated the regulation of CD38 expression and the role of cADPR-mediated Ca2+ release in airway inflammation. "
02/01/1999 - "By virtue of its ability to synthesize cADPR as well as to act as an adhesion and signal transduction molecule, CD38 may play a role in such diverse physiological processes as cell growth, apoptosis, differentiation, and inflammation. "
11/01/2001 - "Thus, CD38 controls neutrophil chemotaxis to bacterial chemoattractants through its production of cyclic ADP-ribose, and acts as a critical regulator of inflammation and innate immune responses."
|3.||Myocardial Ischemia (Ischemic Heart Diseases)
07/01/2002 - "The present study therefore examined the effects of myocardial ischemia and reperfusion on the concentrations of myocardial cADPR using high-performance liquid chromatography. "
07/01/2002 - "These results suggest that myocardial ischemia and reperfusion decrease cADPR in the myocardium by increasing its hydrolysis. "
07/01/2002 - "Myocardial ischemia for 30 min significantly decreased cADPR concentrations to 2.1 +/- 0.4 nmol x mg(-1) protein. "
07/01/2002 - "It is unknown whether myocardial ischemia and reperfusion affect the metabolism of cADPR in the myocardium. "
07/01/2002 - "Myocardial ischemia and reperfusion reduce the levels of cyclic ADP-ribose in rat myocardium."
|4.||Muscular Diseases (Myopathy)
07/28/1995 - "In addition, cADP-ribose appears to be a potent activator of internal Ca2+ release in T-lymphoma cells and is capable of overriding ryanodine-mediated inhibition of internal Ca2+ release. "
07/28/1995 - "In this study, we have identified and partially characterized a mouse T-lymphoma ryanodine receptor on a unique type of internal vesicle which bands at the relatively light density of 1.07 g/ml. Analysis of the binding of [3H]ryanodine to these internal vesicles reveals the presence of a single, low affinity binding site with a dissociation constant (Kd) of 200 nM. The second messenger, cyclic ADP-ribose, was found to increase the binding affinity of [3H]ryanodine to its vesicle receptor at least 5-fold (Kd approximately 40 nM). "
|2.||Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
|5.||Protein Kinases (Protein Kinase)
|6.||Cyclic ADP-Ribose (cADPR)
|9.||Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
|10.||Adenosine Diphosphate Ribose (ADP-Ribose)