ADP-ribosyl Cyclase

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17 relevant articles (0 outcomes, 0 trials/studies) found for this Bio-Agent

Description: A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.

Also Known As:

2'-P-ADPR Cyclase; 2'-Phospho-adenosine Diphosphate Ribose Cyclase; ADPR Cyclase; Adenosine Diphosphate Ribose Cyclase; Cyclic ADP-ribose Hydrolase; cADPR Hydrolase; 2' P ADPR Cyclase; 2' Phospho adenosine Diphosphate Ribose Cyclase; ADP ribosyl Cyclase; ADP-ribose Hydrolase, Cyclic; Cyclase, 2'-P-ADPR; Cyclase, ADP Ribose; Cyclase, ADP-ribosyl; Cyclase, ADPR; Cyclic ADP ribose Hydrolase; Hydrolase, Cyclic ADP-ribose; Hydrolase, cADPR; Ribose Cyclase, ADP; ADP Ribose Cyclase

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzymes: 24378

Transferases: 3171

Glycosyltransferases: 159

Pentosyltransferases

ADP Ribose Transferases: 115

NAD+ Nucleosidase: 51

ADP-ribosyl Cyclase: 17

CD157 antigen: 1

Hydrolases: 572

Glycoside Hydrolases: 227

N-Glycosyl Hydrolases: 1

NAD+ Nucleosidase: 51

ADP-ribosyl Cyclase: 17

CD38 Antigens: 27

CD157 antigen: 1

Experts

1.	Hashii, Minako: 3 articles (03/2007 - 06/2003)
2.	Yokoyama, Shigeru: 3 articles (03/2007 - 06/2003)
3.	Higashida, Haruhiro: 3 articles (03/2007 - 06/2003)
4.	Zhang, Jia-Sheng: 3 articles (03/2007 - 06/2003)
5.	Noda, Mami: 3 articles (03/2007 - 06/2003)
6.	Salmina, Alla: 2 articles (03/2007 - 09/2006)
7.	Hoshi, Naoto: 2 articles (03/2007 - 06/2003)
8.	Jin, Duo: 2 articles (03/2007 - 09/2006)
9.	Zhong, Zen-Guo: 2 articles (03/2007 - 09/2006)
10.	Kuba, Kenji: 1 article (03/2007)

Related Diseases

1.	Neuroblastoma 06/01/2003 - "To determine whether the coupling mode of mGluRs to ADP-ribosyl cyclase is a feature common to individual cloned mGluRs, we expressed each mGluR subtype in NG108-15 neuroblastoma x glioma hybrid cells" 12/12/1997 - "A membrane fraction of NG108-15 neuroblastoma x glioma hybrid cells possessed ADP-ribosyl cyclase activity measured by TLC" 03/01/2007 - "Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells." 09/04/2006 - "Bradykinin activates ADP-ribosyl cyclase in neuroblastoma cells: intracellular concentration decrease in NAD and increase in cyclic ADP-ribose." 01/01/2001 - "Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and beta-adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from beta-NAD+. This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase Cbeta and beta-adrenoceptors to adenylyl cyclase via G proteins" Order ALL the reference details at left...
2.	Neoplasms (Cancer) 03/01/2005 - "Cancer tissues had significantly higher NAD+ glycohydrolase and ADP-ribosyl cyclase activities than the control tissues (43.3 +/- 9.1 vs 29.2 +/- 5.2 and 6.2 +/- 1.6 vs 1.6 +/- 0.4 nmol mg(-1) min(-1))" 10/01/2007 - "RESULTS: Erythrocyte NAD glycohydrolase and ADP-ribosyl cyclase activities were significantly increased in cancer, in parallel to enhancement of CD38 expression and in correlation with CEA values and anemia" 10/01/2007 - "METHODS: Erythrocyte NAD glycohydrolase and ADP-ribosyl cyclase activities in normal individuals and cancer patients were compared and correlation of these activities to CEA values and anemia were determined" 11/15/1999 - "With a total of 12 patients with cervical cancer and 11 women with normal cervix, cancer tissues were found to have significantly higher NADase and ADP-ribosyl cyclase activities than the control group" 01/01/2001 - "Stimulation of muscarinic and beta-adrenergic receptors activates membrane-bound ADP-ribosyl cyclase via G proteins within membranes of neuronal tumor cells and cortical astrocytes" Order ALL the reference details at left...
3.	Glioma (Gliomas) 06/01/2003 - "To determine whether the coupling mode of mGluRs to ADP-ribosyl cyclase is a feature common to individual cloned mGluRs, we expressed each mGluR subtype in NG108-15 neuroblastoma x glioma hybrid cells" 12/12/1997 - "A membrane fraction of NG108-15 neuroblastoma x glioma hybrid cells possessed ADP-ribosyl cyclase activity measured by TLC" 01/01/2001 - "Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and beta-adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from beta-NAD+. This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase Cbeta and beta-adrenoceptors to adenylyl cyclase via G proteins" Order ALL the reference details at left...
4.	Ischemia 07/01/2002 - "However, cADPR hydrolase activity, as measured by the conversion rate of cADPR to ADP-ribose, was significantly elevated by ischemia and reperfusion" 08/01/2003 - "Inclusion of oxygen free radical scavengers, 2,2,6,6-tetramethyl-1-piperidinyloxy and mannitol, in the reperfusate prevented the ischemia/reperfusion-induced increases in cADPR level and the ADP-ribosyl cyclase activity" Order ALL the reference details at left...
5.	Bone Resorption 03/01/2003 - "Disordered osteoclast formation and function in a CD38 (ADP-ribosyl cyclase)-deficient mouse establishes an essential role for CD38 in bone resorption." 09/06/1999 - "CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption." 09/06/1999 - "Taken together, the results provide compelling evidence for a new role for CD38/ADP-ribosyl cyclase in the control of bone resorption, most likely exerted via cADPr." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Cyclic ADP-Ribose (cADPR)
2.	NAD+ Nucleosidase (NAD(P) Nucleosidase)
3.	ADP-ribosyl Cyclase
4.	GTP-Binding Proteins (G-Protein)
5.	Phospholipase C gamma
6.	1-Phosphatidylinositol 3-Kinase (PI 3 Kinase)
7.	Aldosterone Synthase (CYP11B2)
8.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
9.	Bradykinin Receptors (Bradykinin Receptor)
10.	Free Radical Scavengers

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