Ephrin-B3 (Ephrin B3)

A transmembrane domain containing ephrin. Although originally found to be specific for the EPHB3 RECEPTOR it has since been shown to bind a variety of EPH FAMILY RECEPTORS. During embryogenesis ephrin-B3 is expressed at high levels in the ventral neural tube. In adult tissues, it is found primarily in the BRAIN and HEART.

Also Known As:

Networked: 36 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Luo, Hongyu: 3 articles (01/2018 - 04/2016)
2.	Wang, Yujia: 3 articles (01/2018 - 04/2016)
3.	Wu, Jiangping: 3 articles (01/2018 - 04/2016)
4.	Marois-Blanchet, Francois-Christophe: 2 articles (01/2018 - 01/2017)
5.	Raelson, John: 2 articles (01/2018 - 01/2017)
6.	Wu, Tao: 2 articles (01/2018 - 04/2016)
7.	Tremblay, Johanne: 2 articles (01/2017 - 04/2016)
8.	Wu, Zenghui: 2 articles (01/2017 - 04/2016)
9.	Berens, Michael E: 2 articles (09/2006 - 01/2005)
10.	Brodeur, G M: 2 articles (12/2000 - 09/2000)

Related Diseases

1.	Hypertension (High Blood Pressure) 01/01/2017 - "Evidence from single nucleotide polymorphism analyses of ADVANCE study demonstrates EFNB3 as a hypertension risk gene." 01/01/2017 - "Thus, our investigation has shown that EFNB3 is a hypertension risk gene in certain individuals." 01/01/2017 - "We recently reported that Efnb3 gene deletion results in hypertension in female but not male mice. " 04/01/2016 - "Our investigation has revealed previously unknown EFNB3 functions in BP regulation and show that EFNB3 might be a hypertension risk gene in certain individuals. " 01/01/2018 - "Previous animal studies showed that while male EFNB3 gene knockout mice were normotensive, castration of these mice resulted in hypertension, corroborating the results of the human genetic study. "
2.	Neoplasms (Cancer) 09/13/2016 - "In conclusion, we show that blocking Ephrin B3 expression inhibits NSCLC proliferation-, migration- and invasion capacity which calls for further studies on interference with Ephrin B3 as a possible therapeutic avenue in this tumor malignancy." 09/13/2016 - "EphA2 Ser897 was previously shown to drive migration propensity of tumor cells and our study reveals that EphA2 stays phosphorylated on Ser897 in the Ephrin B3/EphA2 complex in NSCLC cells of different histology. " 09/26/2000 - "In this study, we showed that EFNB2 and TrkA expressions were associated with both tumor stage and age, whereas EPHB6 and EFNB3 expressions were solely associated with tumor stage, suggesting that these genes were expressed in distinct subsets of NB. " 04/04/2017 - "Lastly, silencing of Ephrin-B3 decreases tumor vascularization and growth in a xenograft mice model. " 04/04/2017 - "Here, we report that Ephrin-B3 is highly expressed in human biopsies and that it inhibits EphA4 pro-apoptotic activity in tumor cells. "
3.	Pain (Aches) 09/05/2013 - "Electroacupuncture signifi-cantly enhanced the mRNA expression of ephrin-B3 and EphB3/B6 in the dorsal horns of neuro-pathic pain rats. " 04/01/2022 - "In the present study, formalin-induced inflammatory pain, mechanical allodynia and thermal hyperalgesia, was measured using Efnb3 mutant mice (Efnb3-/- ) and wild-type (Efnb3+/+ ) mice. "
4.	Vascular Diseases (Vascular Disease) 01/01/2017 - "In the present study, we conducted a human genetic study to assess the association of EFNB3 single nucleotide polymorphisms with human hypertension risks, using 3,448 patients with type 2 diabetes from the ADVANCE study (Action in Diabetes and Vascular Disease: Peterax and Diamicron MR Controlled Evaluation). "
5.	Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia) 08/01/2007 - "To study the changes of ephrin-B3 mRNA expression and cellular apoptosis in the brain of neonatal rats with periventricular leukomalacia (PVL) and to explore the possible role of ephrin-B3 in the pathogenesis of PVL. " 08/01/2007 - "[Expression of ephrin-B3 mRNA and cellular apoptosis in the brain of neonatal rats with periventricular leukomalacia]."

Related Drugs and Biologics

1.	Testosterone (Sustanon)
2.	Messenger RNA (mRNA)
3.	Ephrin-B1 (Ephrin B1)
4.	Ligands
5.	Gliclazide (Diamicron)
6.	Formaldehyde (Formol)
7.	Ephrin-B3 (Ephrin B3)
8.	Ephrin-B2 (Ephrin B2)
9.	Proteins (Proteins, Gene)
10.	Ephrin-A1 (Ephrin A1)

Related Therapies and Procedures

1.	Castration
2.	Therapeutics
3.	Electroacupuncture