Ephrin-B3 (Ephrin B3)

A transmembrane domain containing ephrin. Although originally found to be specific for the EPHB3 RECEPTOR it has since been shown to bind a variety of EPH FAMILY RECEPTORS. During embryogenesis ephrin-B3 is expressed at high levels in the ventral neural tube. In adult tissues, it is found primarily in the BRAIN and HEART.
Also Known As:
Ephrin B3; EFNB3; EPLG8 Gene Product; LERK-8; LERK-8 Protein; Gene Product, EPLG8; LERK 8 Protein
Networked: 23 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results


1. Berens, Michael E: 2 articles (09/2006 - 01/2005)
2. Evans, A E: 2 articles (12/2000 - 09/2000)
3. Cohn, S L: 2 articles (12/2000 - 09/2000)
4. Brodeur, G M: 2 articles (12/2000 - 09/2000)
5. Robinson, M E: 2 articles (12/2000 - 09/2000)
6. Zhao, H: 2 articles (12/2000 - 09/2000)
7. Ikegaki, N: 2 articles (12/2000 - 09/2000)
8. Cnaan, A: 2 articles (12/2000 - 09/2000)
9. Tang, X X: 2 articles (12/2000 - 09/2000)
10. Cheung, N K: 2 articles (12/2000 - 09/2000)

Related Diseases

1. Neoplasms (Cancer)
2. Periventricular Leukomalacia (Neonatal Cerebral Leukomalacia)
3. Neuroblastoma
4. Infection
01/01/2015 - "Moreover, heparin was shown to bind to ephrin-B3 and to restrain infection of permissive cells in vitro. "
10/01/2011 - "We propose a model whereby SIV infection triggers events that lead to induction of GAP-43 and ephrin B3, and that short-term cART results in increased magnitude of repair mechanisms especially in the hippocampus, a region known for high levels of adult plasticity."
10/01/2011 - "We examined whether the improvement of neuronal metabolism with combined anti-retroviral therapy (cART) after simian immunodeficiency virus (SIV) infection in rhesus macaques involved induction of GAP-43, also known as neuromodulin, and ephrin B3, both implicated in axonal pathfinding during neurodevelopment and regulation of synapse formation, neuronal plasticity, and repair in adult brain. "
10/01/2011 - "Here we demonstrate that (1) GAP-43 mRNA and protein are induced with SIV infection, (2) GAP-43 protein is higher in the hippocampus outer molecular layer in SIV-infected animals that received cART compared to those that did not, and (3) activated microglia and infiltrating SIV-infected macrophages express abundant ephrin B3, an important axonal guidance molecule. "
03/15/2008 - "To determine whether host receptor molecules play a role in species-specific and/or virus-specific infection we have cloned and characterized ephrin-B2 and ephrin-B3 ligands from a range of species, including human, horse, pig, cat, dog, bats (Pteropus alecto and Pteropus vampyrus) and mouse. "
5. Glioma (Gliomas)

Related Drugs and Biologics

1. Messenger RNA (mRNA)
2. Ephrin-B2 (Ephrin B2)
3. Ephrin-B3 (Ephrin B3)
4. Ligands
5. Proteins (Proteins, Gene)
6. Caspase 3 (Caspase-3)
7. bcl-2-Associated X Protein (bcl 2 Associated X Protein)
8. Ephrin-B1 (Ephrin B1)
9. Ephrin-A5 (Ephrin A5)
10. Ephrin-A4 (Ephrin A4)

Related Therapies and Procedures

1. Electroacupuncture
2. Heterologous Transplantation (Xenotransplantation)