Ephrin-A2 (Ephrin A2)

A GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR-containing ephrin with a high affinity for the EPHA3 RECEPTOR. Early in embryogenesis it is expressed at high levels in the MESENCEPHALON; SOMITES; branchial arches, and LIMB BUDS.

Also Known As:

Ephrin A2; Cek7 Ligand; Cek7 RPTK Ligand; ELF-1 Protein, Mammalian; EPLG6 Gene Product; Eph Ligand Family 1 Protein, Mammalian; LERK-6 Protein; ELF 1 Protein, Mammalian; LERK 6 Protein; Ligand, Cek7; Ligand, Cek7 RPTK; Mammalian ELF-1 Protein; RPTK Ligand, Cek7

Networked: 28 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Li, Shibao: 2 articles (07/2021 - 04/2016)
2.	Rodger, Jennifer: 2 articles (01/2019 - 01/2017)
3.	Lee, Kenneth H: 2 articles (05/2015 - 06/2005)
4.	Warchol, Mark E: 2 articles (05/2015 - 06/2005)
5.	Fraguas-Sánchez, Ana Isabel: 1 article (02/2022)
6.	Lozza, Irene: 1 article (02/2022)
7.	Torres-Suárez, Ana Isabel: 1 article (02/2022)
8.	Cassady, Kevin A: 1 article (10/2021)
9.	Chen, Chun-Yu: 1 article (10/2021)
10.	Cripe, Tim: 1 article (10/2021)

Related Diseases

1.	Infections 01/01/2019 - "In the current studies, we have found that EphA4 promotes KSHV glycoprotein H/glycoprotein L (gH/gL)-mediated fusion and infection better than does ephrin A2 (EphA2) in HEK293T cells, indicating that EphA4 is a new KSHV entry receptor. " 10/15/2017 - "In contrast, blocking of both langerin and the receptor protein tyrosine kinase ephrin A2 was required to inhibit HHV-8 infection of LC. " 02/01/2013 - "In addition, NAC inhibited KSHV infection-induced translocation of αVβ3 integrin into lipid rafts, actin-dependent membrane perturbations, such as blebs, observed during macropinocytosis, and activation of the signal molecules ephrin-A2 receptor, FAK, Src, and Rac1. "
2.	Prostatic Neoplasms (Prostate Cancer) 04/01/2016 - "This study aimed to assess the diagnostic and prognostic value of both serum and tissue levels of Ephrin-A2 in prostate cancer (PCa) management. " 07/01/2021 - "We established stable clones overexpressing or silencing ephrin-A2 from prostate cancer cells. " 07/01/2021 - "However, the role of ephrin-A2 in prostate cancer is remains elusive. " 04/01/2016 - "Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer." 07/01/2021 - "These findings indicate that ephrin-A2 promotes prostate cancer metastasis by enhancing angiogenesis and promoting EMT and may be a potentially therapeutic target in metastatic prostate cancer."
3.	Neoplasms (Cancer) 07/01/2021 - "Although ephrin-A2 did not affect tumor cell proliferation in vitro, ephrin-A2 significantly promoted primary tumor growth in vivo. " 04/01/2016 - "The expression of Ephrin-A2 was higher in tumor patients with an elevated Gleason score or T3-T4 staging. " 07/01/2015 - "Expression of Ephrin A2 receptors (EphA2) in cancers and GCSC was evaluated immunohistochemically. " 07/01/2015 - "Overexpression of Ephrin A2 receptors in cancer stromal cells is a prognostic factor for the relapse of gastric cancer." 10/01/2021 - "We therefore developed a multimodal oncolytic herpes simplex virus (oHSV) that expresses ephrin A2 (EphA2), a shared tumor-associated antigen (TAA) expressed by many tumors to improve immune-mediated antitumor activity. "
4.	Ganglion Cysts (Ganglion) 05/01/2015 - "Ephrin-A2 may be involved in the guidance of ganglion cells to hair cells in the chick. " 06/01/2005 - "The changes in ephrin A2 immunoreactivity in acoustic ganglion cells during cochlear damage and regeneration suggests that ephrin A2 may be involved in the guidance of ganglion cells to tonotopically appropriate hair cell targets during regeneration. " 03/25/2012 - "Fluorescence immunohistochemistry analysis revealed few ganglion cells positively labeled for Ephrin A2 in the cochlea of experimental chickens from 2 days before until 7 days after the last kanamycin injection. " 06/01/2005 - "After gentamicin treatment, ephrin A2 expression was lost in a subset of acoustic ganglion cells. " 06/01/2005 - "Ephrin A2 expression was characterized in acoustic ganglion cells of normal and gentamicin-treated early post hatch chicks. "
5.	Ototoxicity 05/01/2015 - "The changes in ephrin-A2 immunoreactivity after gentamicin ototoxicity coincide with the spatio-temporal pattern of hair cell loss and regeneration in the chick cochlea. " 03/25/2012 - "Ephrin A2 may play an important role in the regeneration and plasticity of cochlear hair cells in the chick cochlea following kanamycin ototoxicity. " 03/25/2012 - "Ephrin A2 protein expression in the regeneration and plasticity of cochlear hair cells in chicken following kanamycin ototoxicity."

Related Drugs and Biologics

1.	Glycoproteins (Glycoprotein)
2.	Ephrins
3.	Ligands
4.	Ephrin-A4 (Ephrin A4)
5.	Proteins (Proteins, Gene)
6.	Gentamicins (Gentamicin)
7.	Antigens
8.	Docetaxel (Taxotere)
9.	Claudin-4
10.	Salivary Cystatins

Related Therapies and Procedures

1.	Investigational Therapies (Experimental Therapy)
2.	Therapeutics