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Pterocarpans

A group of compounds which can be described as benzo-pyrano-furano-benzenes which can be formed from ISOFLAVONES by internal coupling of the B ring to the 4-ketone position. Members include medicarpin, phaseolin, and pisatin which are found in FABACEAE.
Networked: 8 relevant articles (0 outcomes, 1 trials/studies) for this Bio-Agent, Comments

Bio-Agent Context: Research Results

Experts

1. Silveira, Edilberto R: 2 articles (09/2014 - 04/2006)
2. Pessoa, Cláudia: 2 articles (09/2014 - 04/2006)
3. Militão, Gardenia C G: 2 articles (09/2014 - 04/2006)
4. Lima, Mary Anne S: 2 articles (09/2014 - 04/2006)
5. Costa-Lotufo, Letícia V: 2 articles (09/2014 - 04/2006)
6. de Moraes, Manoel Odorico: 1 article (09/2014)
7. Veloso, Pérsio Alexandrino: 1 article (09/2014)
8. Prado, Marisa P: 1 article (09/2014)
9. Machado-Santelli, Gláucia M: 1 article (09/2014)
10. da Silva, Alcides J M: 1 article (02/2009)

Related Diseases

1. Leukemia
2. Neoplasms (Cancer)
09/01/2014 - "Pterocarpans induce tumor cell death through persistent mitotic arrest during prometaphase."
03/01/2005 - "Using cytotoxicity against KB cancer cells as a lead, bioguided-fractionation of the petroleum ether and ethyl acetate extracts of Bituminaria morisiana leaves led to the isolation of two new pterocarpans, namely 3,9-dihydroxy-4-(3,3-dimethylallyl) [6a R, 11a R]-pterocarpan, 3-hydroxy-4-(3,3-dimethylallyl)-4'',5''-dehydropyrano[8,9:2'',3''][6a R,11a R]-pterocarpan and one new isoflavone identified as 4',5''-dihydroxy-6''-methoxy-4'',4''-dimethyl-4'',5''-dihydro-6'' H-pyrano[2'',3'':7,8]-isoflavone. "
12/01/2003 - "By in situ staining with diphenylboric acid 2-aminoethyl ester, by thin-layer chromatography, reverse-phase high-performance liquid chromatography, and two-photon laser-scanning microscopy spectrometry, tumor-specific flavones, isoflavones and pterocarpans were detected, namely 7,4'-dihydroxyflavone (DHF), formononetin, and medicarpin. "
05/15/2008 - "Several classes of flavonoids [flavanoids (1-10), flavonol (11), isoflavones (12-18), isoflavanones (19-22), isoflavans (23-26), chalcones (27-30), auronol (31), pterocarpans (32-37), 2-arylbenzofuran (38), and neoflavonoid (39)] and lignans (40-42) isolated from the MeOH extract of Brazilian red propolis were investigated for their cytotoxic activity against a panel of six different cancer cell lines including murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma, and human HT-1080 fibrosarcoma cell lines. "
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3. Adenocarcinoma
4. Lewis Lung Carcinoma
5. Melanoma (Melanoma, Malignant)

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. Isoflavones
3. Flavones
4. Chalcones
5. Lignans
6. Propolis (Bee Bread)
7. Flavonoids
8. neorautenol
9. erybraedin C
10. bitucarpin A

Related Therapies and Procedures

1. Lasers (Laser)

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