EphB1 Receptor

An eph family receptor found primarily in the nervous system. In the embryonic BRAIN EphB1 receptor expression occurs in the mantle layer and increases with the progression of embryogenesis. In adult brain it is found in the several regions including the CEREBELLUM; CEREBRAL CORTEX; and CAUDATE NUCLEUS; and PUTAMEN.

Also Known As:

Networked: 13 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Henkemeyer, Mark: 4 articles (01/2021 - 11/2008)
2.	Song, Xue-Jun: 4 articles (12/2013 - 11/2008)
3.	Liu, Su: 2 articles (12/2013 - 07/2011)
4.	Liu, Yue-Peng: 2 articles (12/2013 - 07/2011)
5.	Liu, Wen-Tao: 2 articles (07/2011 - 11/2008)
6.	Xiong, Li-Ze: 2 articles (07/2011 - 11/2008)
7.	Song, Xue-Song: 2 articles (11/2008 - 11/2008)
8.	Ahmed, Mahmoud S: 1 article (01/2021)
9.	Bachoo, Robert: 1 article (01/2021)
10.	Ismail, Muhammad: 1 article (01/2021)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 01/01/2017 - "Spinal blocking EphB1 receptor activation suppresses ongoing diabetic neuropathic pain." 01/01/2017 - "Activation of EphB1 receptor in the spinal cord is critical to maintaining the established diabetic neuropathic pain, but not to diabetic pain induction. " 01/01/2021 - "Previous studies have demonstrated that the synaptic EphB1 receptor tyrosine kinase is a major mediator of neuropathic pain, suggesting that targeting the activity of this receptor might be a viable therapeutic option. " 11/21/2008 - "Here we demonstrate that the subtype EphB1 receptor is necessary for development of neuropathic pain and physical dependence on morphine. " 07/01/2007 - "Involvement of EphB1 receptor/EphrinB2 ligand in neuropathic pain."
2.	Neoplasms (Cancer) 06/01/2015 - "Loss of ephrin receptor (EphB1) expression may associate with aggressive cancer phenotypes; however, the mechanism of action remains unclear. " 01/01/2004 - "Recent studies have suggested that various isoforms of Grb10 play important roles in mediating insulin/insulin-like growth factor regulation of cell proliferation and apoptosis, whereas Grb7 mediates signaling pathways from FAK and EphB1 receptor to regulate cell migration, which is also implicated in tumor progression. "
3.	Brain Neoplasms (Brain Tumor) 01/01/2017 - "Besides, various recent studies have detected the abnormal expression of EphB1 receptor in different brain tumors. " 01/01/2017 - "Paradoxes of the EphB1 receptor in malignant brain tumors."
4.	Pain (Aches) 01/01/2017 - "EphB1 receptor may be a potential target for relieving the established diabetic pain. " 01/01/2017 - "EphB1 receptor activation in the spinal cord is critical to the maintenance, but not induction of diabetic pain. " 01/01/2017 - "Activation of EphB1 receptor in the spinal cord is critical to maintaining the established diabetic neuropathic pain, but not to diabetic pain induction. " 07/01/2011 - "Production and persistence of these pain behaviors are well correlated with TCI-induced upregulation of EphB1 receptor and its ligand ephrinB2 in the dorsal horn and primary sensory neurons. " 07/01/2011 - "In addition, spinal blocking or targeted mutation of EphB1 receptor reverses morphine tolerance in treating bone cancer pain in rats and defensive pain in mice. "
5.	Hyperalgesia 01/01/2017 - "Spinal blocking EphB1 receptor activation in the late phase after STZ injection significantly suppressed the established mechanical allodynia as well as activation of the astrocytes and microglial cells and activity of TNF-α and IL-1β. " 11/21/2008 - "The results showed that peripheral nerve injury produced thermal hyperalgesia in wild-type (EphB1+/+) control littermate mice, but not in EphB1 receptor homozygous knockout (EphB1-/-) and heterozygous knockdown (EphB1+/-) mice. " 11/21/2008 - "Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morphine in mice." 11/01/2008 - "The results showed that expression of ephrinB1 and EphB1 receptor proteins was significantly upregulated in DRG and SC in a time-dependent manner corresponding to the development of thermal hyperalgesia after CCI. " 10/01/2014 - "Continuing infusion of remifentanil produced a thermal hyperalgesia and mechanical allodynia, which was accompanied with increased protein expression of spinal-level EphB1 receptor, ephrinB1 ligand and Fos; what appeared above was suppressed by pretreatment with EphB1-Fc, an antagonist of ephrinB/EphB or MK-801, and increased pain behaviours induced by intrathecal injection of ephrinB1-Fc, an agonist of ephrinB/EphB, were suppressed by MK-801. "

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Protein-Tyrosine Kinases (Tyrosine Kinase)
3.	Insulin (Novolin)
4.	Insulin-Like Peptides
5.	Ligands
6.	Proteins (Proteins, Gene)
7.	Messenger RNA (mRNA)
8.	Morphine (MS Contin)
9.	Ephrins
10.	Dizocilpine Maleate (Dizocilpine)

Related Therapies and Procedures

1.	Spinal Injections