EphA4 Receptor

An eph family receptor found in variety of tissues including BRAIN. During embryogenesis, EphA4 receptor exhibits a diverse spatial and temporal patterns of expression suggesting its role in multiple developmental processes.

Also Known As:

Receptor, EphA4; Cek-8 Kinase; Eph-A4 Receptor Tyrosine Kinase; EphA4 Protein; Ephrin Receptor A4; Receptor Tyrosine Kinase Eph-A4; Sek-1 Receptor Tyrosine Kinase; Cek 8 Kinase; Eph A4 Receptor Tyrosine Kinase; Receptor Tyrosine Kinase Eph A4; Sek 1 Receptor Tyrosine Kinase

Networked: 36 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Pasquale, Elena B: 4 articles (01/2019 - 10/2008)
2.	Qin, Haina: 3 articles (02/2015 - 10/2008)
3.	Song, Jianxing: 3 articles (02/2015 - 10/2008)
4.	Hazy, Amanda: 2 articles (01/2022 - 01/2020)
5.	Theus, Michelle H: 2 articles (01/2022 - 01/2020)
6.	Wang, Xia: 2 articles (01/2022 - 01/2020)
7.	Lamberto, Ilaria: 2 articles (01/2019 - 07/2012)
8.	Wang, Jiandong: 2 articles (01/2017 - 01/2017)
9.	Nakamura, Toru: 2 articles (12/2015 - 11/2006)
10.	Boyd, Andrew W: 2 articles (01/2013 - 09/2012)

Related Diseases

1.	Spinal Cord Injuries (Spinal Cord Injury) 09/06/2012 - "In a previous study we found that the EphA4 receptor inhibits regeneration following spinal cord injury by blocking regrowth of axons and regulation of astrocyte reactivity. " 06/15/2013 - "We have previously shown that genetic deletion or competitive antagonism of EphA4 receptor activity promotes axonal regeneration and functional recovery in a mouse model of lateral hemisection spinal cord injury. " 05/11/2007 - "Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response."
2.	Pain (Aches) 07/01/2021 - ": Our study demonstrated that EphA4 receptor is involved in the generation and maintenance of CFA-induced chronic inflammatory pain and that blocking the spinal EphA4 receptor could relieve persistent pain behaviors in mice." 07/01/2021 - "Therefore, we explored the role of EphA4 receptor in regulating chronic inflammatory pain.Methods" 07/01/2021 - "Blocking spinal EphA4 receptor suppressed CFA-induced pain behaviors and reduced the expression of Fos protein in spinal cord.Conclusions" 07/01/2021 - "EphA4 receptor was blocked by intrathecal injection of EphA4-Fc, an EphA4 antagonist, and pain behaviors were measured by assessing thermal hyperalgesia and mechanical allodynia. " 12/01/2006 - "These results indicate that upregulation of EphA4 receptor after trauma may prevent the development of abnormal pain syndromes and could potentially be exploited as a preventive analgesic mediator to chronic neuropathic pain."
3.	Ischemia 10/09/2019 - "Inhibition of EphA4 receptor with EphA4-Fc significantly decreased the channel currents after ischemia-reperfusion. " 10/09/2019 - "Moreover, the EphA4 receptor no longer had significant effects on enhanced channel currents following ischemia-reperfusion. " 10/09/2019 - "EphA4 receptor regulates outwardly rectifying chloride channel in CA1 hippocampal neurons after ischemia-reperfusion." 11/01/2014 - "In the present study, we found that the EphA4 receptor and its ephrin-A3 ligand, which were distributed in neurons and astrocytes, respectively, in the hippocampus showed a coincident up-regulation of protein expression in the early stage of ischemia. "
4.	Hydronephrosis 07/01/2013 - "Genetically modified mice, where the cytoplasmic domain of the EphA4 receptor has been substituted by enhanced green fluorescent protein (EphA4gf/gf), develop spontaneous hydronephrosis and provide a model for further studies of the disorder. "
5.	Contusions 05/11/2007 - "To address this possibility, we have examined the expression of EphA4 after SCI in adult rats following a contusion SCI. EphA4 expression studies demonstrated a time-dependent change for EphA4 protein without alterations in beta-actin. "

Related Drugs and Biologics

1.	Ligands
2.	Proteins (Proteins, Gene)
3.	Ephrin-A3 (Ephrin A3)
4.	Actins (F Actin)
5.	enhanced green fluorescent protein
6.	Ephrins
7.	Protein-Tyrosine Kinases (Tyrosine Kinase)
8.	Ephrin-A4 (Ephrin A4)
9.	Tyrosine (L-Tyrosine)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Radiotherapy
2.	Spinal Injections