|1.||Kinch, Michael S: 15 articles (06/2011 - 01/2002)|
|2.||Chen, Jin: 12 articles (03/2015 - 10/2002)|
|3.||Pasquale, Elena B: 8 articles (11/2015 - 12/2002)|
|4.||Pellecchia, Maurizio: 5 articles (07/2015 - 12/2008)|
|5.||Brantley-Sieders, Dana M: 5 articles (03/2015 - 11/2005)|
|6.||Nasreen, Najmunnisa: 4 articles (01/2013 - 11/2006)|
|7.||Mohammed, Kamal A: 4 articles (01/2013 - 11/2006)|
|8.||Wykosky, Jill: 4 articles (08/2012 - 12/2007)|
|9.||Debinski, Waldemar: 4 articles (08/2012 - 12/2007)|
|10.||Fang, Wei Bin: 4 articles (02/2008 - 09/2003)|
03/08/2012 - "We report that the EphA2 receptor is overexpressed preferentially in several human cancer cell lines compared to normal tissues and that an EphA2 targeting peptide (YSAYPDSVPMMS) can be effective in delivering anticancer agents to such tumors. "
07/23/2015 - "In this study, we used a combination of nuclear magnetic resonance-guided structure-activity relationships along with biochemical and cellular studies to derive a novel tumor-homing agent, named 123B9, targeting the EphA2 tyrosine kinase receptor ligand-binding domain. "
01/01/2015 - "In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. "
03/08/2012 - "We believe these studies open the way to the development of a new class of therapeutic compounds that exploit the EphA2 receptor for drug delivery to cancer cells."
01/01/2003 - "In Recent studies have demonstrated that the EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character. "
|2.||Neoplasm Metastasis (Metastasis)
09/01/2011 - "The positive expression of EphA2 protein was correlated with the clinical stage, the neck lymph node metastasis and distant metastasis, and prognosis of NPC, respectively (P < 0.05). "
09/01/2011 - "The positive rates of EphA2 protein in NPC were 27.27% (3/11) in stage I, 56.25% (9/16) in stage II, 68.19% (15/22) in stage III, and 83.33% (10/12) in stage IV. The positive expressions of EphA2 in T1 + T2 and T3 + T4 with neck lymph node and distant metastasis were 58.33% (7/12) and 88.89% (16/18) respectively, while those in T1 +T2 and T3 + T4 without metastasis were 31.25% (5/16) and 50.00% (6/12) respectively. "
03/01/2011 - "The results of this study demonstrate that EphA2 protein expression is significantly increased in LSCC tissues and cell lines, and EphA2 protein overexpression is associated with tumor recurrence, metastasis and poorer prognosis in LSCC patients. "
07/01/2009 - "Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis."
01/15/2006 - "The EphA2 receptor tyrosine kinase is believed to play a role in tumor growth and metastasis. "
|3.||Breast Neoplasms (Breast Cancer)
04/01/2011 - "In principle, this protocol is widely applicable to eukaryotic cells and herein is specifically developed to study the role of physical organization and translocation of the EphA2 receptor tyrosine kinase across a library of model breast cancer cell lines."
06/01/2011 - "Overexpression and altered function of EphA2 receptor tyrosine kinase are critical in the progression of breast cancer and provide a target for breast cancer therapy. "
01/01/2005 - "A recent report, however, indicated that stimulation of the EPHA2 receptor ligand, ephrinA1 (EFNA1), inhibits the growth of EPHA2-expressing breast cancer. "
11/01/2004 - "The EphA2 receptor tyrosine kinase is frequently overexpressed in invasive breast cancer cells. "
06/15/2003 - "The EphA2 receptor tyrosine kinase is found at low levels on nontransformed adult breast epithelial cells but is frequently overexpressed on aggressive breast cancer cells. "
|4.||Glioblastoma (Glioblastoma Multiforme)
08/01/2005 - "We demonstrate in the current study that the EphA2 protein is restrictedly expressed in primary glioblastoma multiforme and anaplastic astrocytoma tissues in comparison to normal brain tissues. "
01/01/2015 - "It has been shown that the EphA2 receptor tyrosine kinase (RTK) is overexpressed in a number of tumors, including glioblastoma. "
12/11/2012 - "The EphA2 receptor drives self-renewal and tumorigenicity in stem-like tumor-propagating cells from human glioblastomas."
04/20/2012 - "The EphA2 receptor is overexpressed in glioblastoma multiforme and has been to shown to contribute to cell transformation, tumor initiation, progression, and maintenance. "
12/01/2007 - "We have previously shown that the EphA2 receptor tyrosine kinase is overexpressed in glioblastoma multiforme (GBM) and represents a novel, attractive therapeutic target for the treatment of brain tumors. "
05/08/2012 - "Taken together, these studies demonstrate that the EphA2 receptor acts as a master assembly regulator of KSHV-induced signal molecules and KSHV entry in endothelial cells and suggest that the EphA2 receptor is an attractive target for controlling KSHV infection."
12/01/2014 - "Hence, simultaneous targeting of the receptor EphA2 and scaffolding action of p130Cas can potentially uncouple the signal cross talk of the KSHV entry-associated upstream signal complex from the immediate downstream trafficking-associated signalosome, consequently routing KSHV toward lysosomal degradation and eventually blocking KSHV infection and associated malignancies."
06/15/2009 - "Mycobacterium tuberculosis interferes with the response to infection by inducing the host EphA2 receptor."
11/27/2015 - "Malaria parasites target the hepatocyte receptor EphA2 for successful host infection."
11/01/2009 - "EphA2 receptor mediates increased vascular permeability in lung injury due to viral infection and hypoxia."
|1.||Ephrin-A1 (Ephrin A1)
|3.||Polyethylene Glycols (Polyethylene Glycol)
|6.||Quaternary Ammonium Compounds (Ammonium)
|7.||1,2- dioleoyloxy- 3- (trimethylammonium)propane
|2.||Heterologous Transplantation (Xenotransplantation)