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Iron Regulatory Protein 1

A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Also Known As:
ACO1 Protein; Aconitase 1, Soluble; Ferritin Repressor Protein; IRE-BP1; IRP-1 Protein; IRP1 Protein; IRE BP1; IRP 1 Protein; Repressor Protein, Ferritin; Soluble Aconitase 1
Networked: 21 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kovtunovych, Gennadiy: 2 articles (02/2013 - 05/2010)
2. Rouault, Tracey A: 2 articles (02/2013 - 05/2010)
3. Ghosh, Manik C: 2 articles (02/2013 - 05/2010)
4. Jeong, Suh Young: 2 articles (02/2013 - 05/2010)
5. Silvestri, Laura: 2 articles (05/2010 - 08/2007)
6. Camaschella, Clara: 2 articles (05/2010 - 08/2007)
7. Moore, Joseph P: 2 articles (06/2009 - 10/2008)
8. Barati, Michelle T: 2 articles (06/2009 - 10/2008)
9. Song, Ying: 2 articles (06/2009 - 10/2008)
10. Villafuerte, Betty C: 2 articles (06/2009 - 10/2008)

Related Diseases

1. Insulin Resistance
2. Parkinson Disease (Parkinson's Disease)
3. Anoxia (Hypoxia)
4. Neoplasms (Cancer)
5. Iron Overload

Related Drugs and Biologics

1. Iron
2. Transferrin Receptors (Transferrin Receptor)
3. Insulin (Novolin)
4. metal transporting protein 1 (ferroportin)
5. Glutaredoxins
6. Hypoxanthine
7. Synaptophysin
8. Triose-Phosphate Isomerase (Triosephosphate Isomerase)
9. Transferases
10. Tetracycline (Achromycin)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)