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MicroRNAs (MicroRNA)

Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Also Known As:
MicroRNA; miRNA; miRNAs; Micro RNA; RNA, Micro; Primary MicroRNA; Primary miRNA; pre-miRNA; pri-miRNA; MicroRNA, Primary; Temporal RNA, Small; miRNA, Primary; pre miRNA; pri miRNA; RNA, Small Temporal; Small Temporal RNA; stRNA
Networked: 18676 relevant articles (328 outcomes, 3841 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Croce, Carlo M: 193 articles (12/2015 - 11/2002)
2. Calin, George A: 146 articles (01/2016 - 07/2005)
3. Zhang, Wei: 85 articles (12/2015 - 11/2008)
4. Volinia, Stefano: 73 articles (03/2015 - 08/2005)
5. Negrini, Massimo: 61 articles (11/2015 - 11/2002)
6. Chen, Xi: 59 articles (01/2016 - 06/2008)
7. Liu, Chang-Gong: 57 articles (01/2015 - 06/2004)
8. Li, Jun: 55 articles (01/2016 - 01/2010)
9. Seki, Naohiko: 52 articles (02/2016 - 07/2009)
10. Thum, Thomas: 52 articles (12/2015 - 07/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Infection
3. Breast Neoplasms (Breast Cancer)
4. Lung Neoplasms (Lung Cancer)
5. Inflammation

Related Drugs and Biologics

1. MicroRNAs (MicroRNA)
2. Biological Markers (Surrogate Marker)
3. Messenger RNA (mRNA)
4. RNA (Ribonucleic Acid)
5. Curcumin
6. Proteins (Proteins, Gene)
7. Histones (Histone)
8. resveratrol
9. Insulin (Novolin)
10. Chromatin

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Heterologous Transplantation (Xenotransplantation)
4. Radiotherapy
5. Lasers (Laser)