Transcription Factor TFIIIA

One of several general transcription factors that are specific for RNA POLYMERASE III. It is a zinc finger (ZINC FINGERS) protein and is required for transcription of 5S ribosomal genes.

Also Known As:

Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Matoušek, Jaroslav: 1 article (01/2022)
2.	Steger, Gerhard: 1 article (01/2022)
3.	Dawe, Angus L: 1 article (10/2018)
4.	Dissanayaka Mudiyanselage, Shachinthaka D: 1 article (10/2018)
5.	Jiang, Jian: 1 article (10/2018)
6.	Ren, Di: 1 article (10/2018)
7.	Smith, Heather N: 1 article (10/2018)
8.	Wang, Lei: 1 article (10/2018)
9.	Wang, Ying: 1 article (10/2018)
10.	Bartfai, Richard: 1 article (03/2017)

Related Diseases

1.	Decompression Sickness (Bends) 08/10/1989 - "Using both circular permutation and circularization assays we provide convincing biochemical evidence that TFIIIA bends the DNA at the internal promoter of the 5S gene." 01/01/1989 - "Electron microscopy reveals that transcription factor TFIIIA bends 5S DNA." 12/20/1992 - "Although our data do not allow us directly to link the two bends, our results suggest that TFIIIA could form a folded structure by stabilizing the same bent conformation that is induced by binding of Zn2+. The chemistry of Zn2+ binding to DNA, and the sequence around the bend center, suggest that the bend is most probably caused by joint co-ordination of Zn2+ to the N-7 groups of stacked purine residues."
2.	Neoplasms (Cancer) 01/09/2002 - "A monoclonal antibody against human p53 tumor suppressor bound to rat and mouse TFIIIA but not to human TFIIIA in Western blots. " 04/05/1999 - "The homologous proteins are: KH domain-containing protein overexpressed in cancer (Koc); zipcode binding protein, a protein which binds to a conserved nucleotide element in chicken beta-actin mRNA (ZBP1); and a protein which binds to a promoter cis element in Xenopus laevis TFIIIA gene (B3). "
3.	Glioblastoma (Glioblastoma Multiforme) 04/01/1995 - "Sequence analysis indicates that the protein encoded by the ZSG-1 transcript contains a domain of five fingers similar to the zinc finger repeats of the Xenopus transcription factor TFIIIA, the product of Drosophila segment polarity gene cubitus interruptus (ci) and the human zinc finger protein GLI, which has been found to be amplified in several human glioblastomas. " 06/01/1990 - "Sequence analysis indicates that the protein encoded by the ciD transcript contains a domain of five tandem amino acid repeats that have sequence similarity to the zinc-finger repeats of the Xenopus transcription factor TFIIIA and that share the highest degree of identity with the human zinc-finger protein GLI, which has been found to be amplified in several human glioblastomas."
4.	Common Variable Immunodeficiency 11/25/2022 - "Here, we identify compound heterozygous loss-of-function mutations in the gene GTF3A encoding for transcription factor IIIA (TFIIIA), a component of the RNA polymerase III complex, in a patient with common variable immunodeficiency and HSE. "
5.	Virus Diseases (Viral Diseases) 11/01/1987 - "Among four distinct components required for accurate transcription in vitro from cloned DNA templates, activities of RNA polymerase III and transcription factor TFIIIA were not significantly affected by virus infection. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Proteins (Proteins, Gene)
3.	Transcription Factor TFIIIA
4.	RNA Polymerase III
5.	Carrier Proteins (Binding Protein)
6.	Messenger RNA (mRNA)
7.	Nucleotides
8.	Elements
9.	Monoclonal Antibodies
10.	Amino Acids