Transcription Factor TFIIA (TFIIA)

An RNA POLYMERASE II specific transcription factor. It may play a role in transcriptional activation of gene expression by interacting with the TATA-BOX BINDING PROTEIN component of TRANSCRIPTION FACTOR TFIID.

Also Known As:

TFIIA; RNA Polymerase II, Transcription Factor A

Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Awah, Chidiebere U: 1 article (12/2021)
2.	Mazdoom, Claudiane M: 1 article (12/2021)
3.	Ogunwobi, Olorunseun O: 1 article (12/2021)
4.	Winter, Jan: 1 article (12/2021)
5.	Cramer, Patrick: 1 article (01/2021)
6.	Wang, Haibo: 1 article (01/2021)
7.	Xiong, Le: 1 article (01/2021)
8.	Dvorak, Pavel: 1 article (01/2019)
9.	Leupen, Sarah: 1 article (01/2019)
10.	Soucek, Pavel: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 05/11/2001 - "The NH(2)-terminal kinase domain of TAF(II)250 was sufficient for TFIIA phosphorylation, and this activity was inhibited by full-length retinoblastoma protein but not by a retinoblastoma protein mutant defective for TAF(II)250 interaction or tumor suppressor activity. " 01/01/2019 - "Exon and intron enhancers and silencers (sc35, ighg2 cgamma2, ctnt, gh-1, and fibronectin eda exon), transcription factors (TFIIA, TATA, NFAT1, NFAT4, and HOXA13), some of them cancer related, and microRNA (hsa-miR-4474-3p) were localized to these regions. "
2.	Decompression Sickness (Bends) 09/21/2007 - "Our results indicate that human TFIIA decreases the angle to which human TBP bends consensus TATA DNA from 104 degrees to 80 degrees when calculated using a two-kink model. " 01/01/2021 - "TBP binds and bends DNA, and directs adjacent binding of the transcription factors TFIIA and TFIIB for PIC assembly. "
3.	Carcinogenesis 11/02/2017 - "In contrast, the relevance of Taspase1-mediated TFIIA cleavage during oncogenesis of HNSCC is not characterized yet. "
4.	Tics (Tic) 11/01/1998 - "Furthermore, we demonstrate an essential function for TFIIA in TIC- and TAFII-dependent basal transcription from a TATA-less promoter. "
5.	Embryonal Carcinoma 09/01/2000 - "We have identified a highly stable TBP-TFIIA-containing complex, TAC, which is detectable in embryonal carcinoma (EC) cells but not in differentiated cells. "

Related Drugs and Biologics

1.	tributyl phosphate (TBP)
2.	Transcription Factors (Transcription Factor)
3.	Proteins (Proteins, Gene)
4.	DNA (Deoxyribonucleic Acid)
5.	Basic Helix-Loop-Helix Transcription Factors
6.	MicroRNAs (MicroRNA)
7.	Transcription Factor TFIIB (TFIIB)
8.	Ubiquitin
9.	Butyric Acid (Butanoic Acid)
10.	Annexin A1