Telomeric Repeat Binding Protein 2

A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the cell cycle. It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. It is structurally different from TELOMERIC REPEAT BINDING PROTEIN 1 in that it contains basic N-terminal amino acid residues.

Also Known As:

TERF2 Protein; TRBF2 Protein; Trf2 Gene Product; Gene Products, Trf2; Products, Trf2 Gene; Proteins, TERF2; Proteins, TRBF2; Proteins, TRF2; TERF2 Proteins; TRBF2 Proteins; TRF2 Proteins; Trf2 Gene Products; TRF2 Protein

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Amoreo, Carla Azzurra: 1 article (01/2017)
2.	Benarroch-Popivker, Delphine: 1 article (01/2017)
3.	Biroccio, Annamaria: 1 article (01/2017)
4.	Capolupo, Angela: 1 article (01/2017)
5.	Cosconati, Sandro: 1 article (01/2017)
6.	D'Angelo, Carmen: 1 article (01/2017)
7.	Del Gaudio, Federica: 1 article (01/2017)
8.	Di Maro, Salvatore: 1 article (01/2017)
9.	Gilson, Eric: 1 article (01/2017)
10.	Iachettini, Sara: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2007 - "Accumulation of the TRF2 protein was detected in 16 of 80 (20%) tumors and PML and TRF2 colocalization in 2 MSI-H tumors (6%). " 03/23/2006 - "This study also identifies the TRF2 protein as a therapeutic target for treating many types of cancer which have the TRF2 protein at caps of the telomere DNA of each chromosome." 11/01/2023 - "Ectopic expression of miR-182-3p drastically reduced TRF2 protein levels in a panel of telomerase- or alternative lengthening of telomeres (ALT)-positive cancer cell lines. " 03/23/2006 - "G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells." 01/01/2015 - "We have seen correlation, if any, of the transcription factor - β-catenin, telomere maintenance and shelterin complex proteins - TRF2, Rap1 and hTert with respect to tumor differentiation and telomere dysfunction. "
2.	Carcinogenesis 01/01/2017 - "Taken together our findings describe TRF2 as a novel SIRT6 substrate and demonstrate that acetylation of TRF2 plays a crucial role in the regulation of TRF2 protein stability, thus providing a new route for modulating its expression level during oncogenesis and damage response."
3.	Microsatellite Instability 11/01/2010 - "Immuno-FISH analysis illustrated early loss of TRF2 protein suggestive of telomeric dysfunction due to premature senescence and plausible association with chromosomal and microsatellite instability. "
4.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2016 - "Lung function, leukocyte telomere length, lymphocyte gene expression of anti-aging (sirtuin 1, total klotho, and soluble klotho [Sklotho]), senescence (p16/21), and DNA repair (Ku70/80 and TERF2) proteins, and markers of systemic inflammation and oxidative stress were determined in 160 patients with COPD, 82 smoking subjects, and 38 never-smoking control subjects. "
5.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2009 - "Overexpression of TRF2 protein was detected in SW480 cells and 19 of 39 colorectal carcinoma tissues (49%), no overexpression was observed in 21 of 21 adjacent peritumoral normal colorectal tissues. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Sirtuin 1
3.	Catenins
4.	Telomerase (Telomerase Reverse Transcriptase)
5.	Transcription Factors (Transcription Factor)
6.	Shelterin Complex
7.	Arsenic Trioxide (Trisenox)
8.	telomestatin