Integration Host Factors

Bacterial proteins that are used by BACTERIOPHAGES to incorporate their DNA into the DNA of the "host" bacteria. They are DNA-binding proteins that function in genetic recombination as well as in transcriptional and translational regulation.

Also Known As:

Networked: 34 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bakaletz, Lauren O: 3 articles (01/2020 - 07/2013)
2.	Goodman, Steven D: 3 articles (01/2020 - 07/2013)
3.	Rice, Phoebe A: 3 articles (09/2013 - 03/2007)
4.	Harshavardhana, Yadumurthy: 2 articles (01/2018 - 10/2017)
5.	Muniyappa, K: 2 articles (01/2018 - 10/2017)
6.	Sharadamma, Narayanaswamy: 2 articles (01/2018 - 10/2017)
7.	Ansari, Anjum: 2 articles (09/2013 - 05/2012)
8.	Kuznetsov, Serguei V: 2 articles (09/2013 - 05/2012)
9.	Velmurugu, Yogambigai: 2 articles (09/2013 - 05/2012)
10.	Vivas, Paula: 2 articles (09/2013 - 05/2012)

Related Diseases

1.	Hypersensitivity (Allergy) 09/05/1992 - "DNase I protection and potassium permanganate hypersensitivity in the presence of integration host factor (IHF), which binds and alters the DNA structure upstream of Pe, revealed that RNA polymerase was able to bind Pe irrespective of the Ner.DNA-bound complex, and partially unwind the Pe "-10 region." Ner repression of Pe transcription in vitro was significantly more effective in the absence of IHF. "
2.	Cystic Fibrosis (Mucoviscidosis) 07/01/2013 - "Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis." 07/01/2013 - "This study aims to identify whether the bacterial protein, Integration Host Factor (IHF), is present within sputum solids collected from cystic fibrosis (CF) patients and thus might contribute to the structural stability of biofilms within the lungs. " 10/01/1996 - "The role of integration host factor (IHF) in the regulation of alginate synthesis was investigated in a mucoid strain of Pseudomonas aeruginosa (strain CHA) isolated from a cystic fibrosis patient. "
3.	Decompression Sickness (Bends) 03/01/1993 - "The attP-cos-ctx region contains six kinds of repeats and integration host factor-binding sequences and showed sequence-directed static bends, suggesting its potential to form a highly ordered structure. " 08/01/1990 - "Intrinsic bends and integration host factor binding at F plasmid oriT." 01/01/2022 - "The integration host factor (IHF) is a prominent example of indirect readout as it imposes one of the strongest bends on relaxed linear DNA. " 01/01/2021 - "Integration host factor (IHF) is an Escherichia coli NAP that creates very sharp bends in DNA at sequences relevant to several functions including transcription and recombination, and is also responsible for general DNA compaction when bound non-specifically. " 01/01/2021 - "Integration host factor bends and bridges DNA in a multiplicity of binding modes with varying specificity."
4.	Genomic Instability 01/01/2018 - "Correction for Sharadamma et al., "Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination"." 10/01/2017 - "Defining the Functionally Important Domain and Amino Acid Residues in Mycobacterium tuberculosis Integration Host Factor for Genome Stability, DNA Binding, and Integrative Recombination."
5.	Coinfection 06/01/2017 - "Using a clinically relevant viral-bacterial coinfection model of NTHI-induced OM, we performed transcutaneous immunization (TCI) via a band-aid delivery system to administer each of three promising NTHI vaccine candidates derived from bacterial adhesive proteins and biofilm mediators: recombinant soluble PilA (rsPilA), chimV4, and integration host factor. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	DNA-Directed RNA Polymerases (RNA Polymerase)
3.	Potassium Permanganate
4.	Deoxyribonuclease I (Nickase)
5.	Bacterial Proteins (Bacterial Protein)
6.	Proteins (Proteins, Gene)
7.	Histones (Histone)
8.	DNA-Binding Proteins (DNA Binding Protein)
9.	Amino Acids
10.	Clavulanic Acid (Potassium Clavulanate)