Lamin Type A (Lamin A)

03/02/2021 - "Author Correction: Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome."
01/01/2021 - "Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome."
10/03/2016 - "Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype."
01/01/2015 - "Since ITLs are associated with telomere stability and require functional lamin A/C, our study suggests a mechanistic link between cellular aging (replicative senescence induced by telomere shortening) and organismal aging (modeled by Hutchinson Gilford Progeria Syndrome). "
03/01/2006 - "These studies suggest a new therapeutic strategy for treating progeria and other lamin A diseases."

03/01/2017 - "Lamin A/C Cardiomyopathies: Current Understanding and Novel Treatment Strategies."
06/20/2011 - "CMR is an accurate tool to determine the typical cardiac involvement in lamin A/C cardiomyopathy and may help to initiate early treatment in this malignant familiar form of DCM."
10/01/2016 - "The objective of this study was to evaluate patients with known hereditary cardiac conduction and myocardial disease (HCCMD) caused by a lamin A/C gene mutation for skeletal muscle involvement using magnetic resonance imaging (MRI) computed tomography (CT). "
11/04/2022 - "We uncover divergent functions of lamin A/C in naïve pluripotent stem cells and cardiomyocytes, which have distinct contributions to the transcriptional alterations of patients with LMNA-associated cardiomyopathy. "
08/01/2022 - "A case report of successful physiological pacing in a patient with lamin A/C cardiomyopathy."

10/01/2015 - "The present study aimed to examine and analyze cardiac involvement in two Emery‑Dreifuss muscular dystrophy (EDMD) pedigrees caused by the c.1583 C→G mutation of the lamin A/C gene (LMNA). "
01/01/2015 - "This study aimed to analyze the correlation between the phenotype and genotype of Chinese patients with early-onset lamin A (LMNA)-related muscular dystrophy (MD). "
01/01/2020 - "Dropped head related lamin A/C associated congenital muscular dystrophy case; previously defined as emerydreifuss muscular dystrophy."
01/01/2020 - "Our findings establish a direct link between lamin A and PcG epigenetic silencing and indicate that lamin A-dependent muscular dystrophy can be ascribed to intrinsic epigenetic dysfunctions of muscle stem cells."
01/01/2020 - "Dysfunctional polycomb transcriptional repression contributes to lamin A/C-dependent muscular dystrophy."

07/01/2023 - "The present study findings suggest that decreased lamin A and B1 expression might lead to nuclear enlargement and deformation and raise the possibility that tumor cells maintaining or not losing lamin A expression might metastasize to lymph nodes."
01/01/2021 - "Our study suggests that Lamin A/C expression could be involved in the organ tropism of tumor cells, thereby providing a rationale for further studies focused on the definition of cancer mechanism of metastatization."
12/01/2014 - "These studies suggest that cellular aging including expression of Δ50 lamin A and nuclear stiffening may reduce the potential for metastatic cancer migration. "
09/26/2007 - "Two findings from this study also increase the likelihood that lamin A/C functions as a tumor suppressor. "
12/01/2023 - "Our data showed that depletion of the tumor suppressor PBRM1 can upregulate lamin A/C levels, and lamin A/C could interact with PBRM1. "

01/01/2013 - "Therefore Zmpste24-deficient mice provide an ideal mouse model to study the impact of lamin A and (premature) aging on the aging-related decline of B lymphopoiesis. "
06/01/2012 - "The results of this study suggest that lamin A is up-regulated in OA chondrocytes, and that increased nuclear accumulation of lamin A in response to catabolic stress may account for the premature aging phenotype and apoptosis of OA chondrocytes."
02/01/2009 - "Recent studies have associated mutations in lamin A/C, a component of the nuclear lamina, with premature aging and severe bone loss. "
01/01/2023 - "These findings provide insight into how loss of the C-terminal region of lamin A may induce premature aging. "
12/31/2022 - "Structural basis for the interaction between unfarnesylated progerin and the Ig-like domain of lamin A/C in premature aging disorders."