RNA-Induced Silencing Complex

A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).

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Networked: 57 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Arenz, Christoph: 2 articles (01/2020 - 11/2012)
2.	Liu, Yan: 2 articles (01/2019 - 05/2011)
3.	Shi, Yang: 2 articles (01/2018 - 12/2011)
4.	Bechara, Falk G: 2 articles (09/2017 - 11/2012)
5.	Lee, Sug Hyung: 2 articles (05/2013 - 04/2010)
6.	Yoo, Nam Jin: 2 articles (05/2013 - 04/2010)
7.	Abuetabh, Yasser: 1 article (04/2022)
8.	Davidge, Sandra T: 1 article (04/2022)
9.	Eisenstat, David D: 1 article (04/2022)
10.	Flores, Elsa R: 1 article (04/2022)

Related Diseases

1.	Glioma (Gliomas) 01/01/2020 - "Mechanistically, EIF3J-AS1 relieved ANXA11 from miR-1343-3p silencing in the EIF3J-AS1/miR-1343-3p/ANXA11 RNA induced silencing complex (RISC), thus eliciting promoting effects on glioma progression. "
2.	Infections 08/19/2023 - "In primary human trophoblast cultures (n=5 donor placentae), we performed Argonaute high-throughput sequencing ultraviolet-crosslinking and immunoprecipitation to identify any significant alterations in the functional loading of microRNAs and their targets onto the RNA-induced silencing complex. Trophoblasts from same-donors were split and infected with a contemporary first-passage Zika virus strain HN16 (multiplicity of infection=1 plaque forming unit per cell) or mock infected. " 01/01/2016 - "necatrix revealed that RnMBV1 infection induced silencing of the target sensor gene (GFP gene and the partial RnMBV1 sequence), suggesting that vsRNAs from RnMBV1 activated the RNA-induced silencing complex. " 03/01/2015 - "These RNAs are expressed during productive infection by either bacterial artificial chromosome (BAC)-derived virus in Jjhan cells or wild-type HHV-6A strain U1102 virus in HSB2 cells and are associated with the RNA induced silencing complex (RISC) machinery. " 01/01/2015 - "The last decades have seen the development of a large number of crops whose inherent posttranscriptional gene silencing mechanism has been exploited to target essential viral genes through the production of dsRNA that triggers an endogenous RNA-induced silencing complex (RISC), leading to gene silencing in susceptible viruses conferring them with resistance even before the onset of infection. " 11/19/2013 - "Here, we provide evidence for the presence of discrete small RNAs of viral origin that are not associated with the RNA-induced silencing complex (RISC), that are highly expressed and detected by Northern blot analysis, and that accumulate as 21- to 28-nucleotide (nt) species during infection. "
3.	Prostatic Neoplasms (Prostate Cancer) 04/01/2017 - "The purpose of this study is to evaluate the potential association between genetic variants in genes encoding the components of RNA-induced silencing complex and prostate cancer (PCa) risk. " 04/01/2017 - "Genetic variants in RNA-induced silencing complex genes and prostate cancer."
4.	Urinary Bladder Neoplasms (Bladder Cancer) 05/01/2011 - "Silencing of survivin and PLK1 mRNA was confirmed to be RNA-induced silencing complex mediated as specific cleavage products were detected in bladder tumors over the duration of the study. "
5.	Neoplasms (Cancer) 07/28/2022 - "These sno-derived RNAs (sdRNAs) have been implicated as gene regulators in a multitude of cancers, controlling a variety of genes post-transcriptionally via association with the RNA-induced silencing complex (RISC). " 07/01/2022 - "Our prior work described an essential role for Argonaute 2 (AGO2), of the RNA-induced silencing complex, in mutant KRAS-driven cancers. " 01/01/2022 - "As a key component of the RNA-induced silencing complex (RISC), Argonaute2 (Ago2) exhibits a dual function regulatory role in tumor progression. " 01/01/2022 - "Argonaute 2 (Ago2) is an essential component of the RNA-induced silencing complex (RISC) and it participates in diverse physiological processes, while dysregulation of Ago2 activity is closely linked to a variety of human diseases including cancers. " 11/06/2015 - "Argonaute 2 (AGO2), a central component of RNA-induced silencing complex, plays critical roles in cancer. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Ribonucleases (Ribonuclease)
3.	Survivin
4.	MicroRNAs (MicroRNA)
5.	Proteins (Proteins, Gene)
6.	Small Interfering RNA (siRNA)
7.	RNA (Ribonucleic Acid)
8.	Viral RNA
9.	Nucleotides
10.	Luciferases