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Small Interfering RNA (siRNA)

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Also Known As:
siRNA; RNA, Small Interfering; Short Hairpin RNA; Short Interfering RNA; Small Hairpin RNA; scnRNA; shRNA; tasiRNA; Hairpin RNA, Short; Hairpin RNA, Small; Interfering RNA, Short; Interfering RNA, Small; RNA, Short Hairpin; RNA, Short Interfering; RNA, Small Hairpin; RNA, Small Scan; Repeat Associated siRNA; Scan RNA, Small; Trans Acting siRNA; siRNA, Repeat Associated; siRNA, Trans Acting; RNA, Scan; Repeat-Associated siRNA; Scan RNA; Small Scan RNA; Trans-Acting siRNA; siRNA, Repeat-Associated; siRNA, Trans-Acting
Networked: 25779 relevant articles (1206 outcomes, 2967 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Zhang, Wei: 123 articles (11/2022 - 02/2005)
2. Wang, Wei: 94 articles (01/2022 - 04/2005)
3. Liu, Yang: 83 articles (02/2022 - 03/2009)
4. Li, Yan: 81 articles (01/2022 - 09/2005)
5. Wang, Jing: 80 articles (06/2022 - 04/2006)
6. Sood, Anil K: 71 articles (01/2021 - 08/2005)
7. Wang, Yan: 69 articles (02/2022 - 12/2005)
8. Zhang, Jing: 67 articles (11/2022 - 03/2004)
9. Wang, Lei: 67 articles (06/2022 - 01/2006)
10. Wang, Jun: 67 articles (04/2022 - 07/2006)

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1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Infections
4. Inflammation (Inflammations)
5. Neoplasm Metastasis (Metastasis)

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1. Small Interfering RNA (siRNA)
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6. Survivin
7. Peptides (Polypeptides)
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1. Therapeutics
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5. Lasers (Laser)