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Systemic Mastocytosis

A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone marrow, liver, spleen, lymph nodes, and gastrointestinal tract. Systemic mastocytosis is commonly seen in adults. These diseases are categorized on the basis of clinical features, pathologic findings, and prognosis.
Also Known As:
Mastocytosis, Systemic; Aggressive Systemic Mastocytosis; Indolent Systemic Mastocytosis; Aggressive Systemic Mastocytoses; Indolent Systemic Mastocytoses; Mast-Cell Disease, Systemic; Mast-Cell Diseases, Systemic; Mastocytoses, Aggressive Systemic; Mastocytoses, Indolent Systemic; Mastocytoses, Systemic; Mastocytosis, Aggressive Systemic; Mastocytosis, Indolent Systemic; Systemic Mast Cell Disease; Systemic Mast-Cell Diseases; Systemic Mastocytoses; Systemic Mastocytoses, Aggressive; Systemic Mastocytoses, Indolent; Systemic Mastocytosis, Aggressive; Systemic Mastocytosis, Indolent; Systemic Mast-Cell Disease
Networked: 467 relevant articles (34 outcomes, 34 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Anaphylaxis (Anaphylactic Shock)
2. Mastocytosis (Mast-Cell Disease)
3. Hypersensitivity (Allergy)
4. Urticaria Pigmentosa
5. Myelodysplastic Syndromes (Myelodysplastic Syndrome)

Experts

1. Valent, Peter: 32 articles (12/2015 - 01/2002)
2. Tefferi, Ayalew: 19 articles (03/2010 - 11/2002)
3. Horny, Hans-Peter: 18 articles (12/2015 - 01/2002)
4. Akin, Cem: 18 articles (10/2014 - 07/2002)
5. Sperr, Wolfgang R: 16 articles (10/2014 - 01/2002)
6. Valent, P: 15 articles (05/2015 - 08/2000)
7. Pardanani, Animesh: 13 articles (03/2010 - 11/2002)
8. Sotlar, Karl: 12 articles (12/2015 - 01/2005)
9. Metcalfe, Dean D: 11 articles (12/2015 - 07/2002)
10. Escribano, Luis: 10 articles (11/2015 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Systemic Mastocytosis:
1. imatinib (Gleevec)FDA Link
2. VenomsIBA
3. Interferon-alpha (Interferon Alfa)FDA Link
4. Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric
5. Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
6. dasatinib (BMS 354825)FDA Link
7. omalizumab (Xolair)FDA Link
8. CladribineFDA LinkGeneric
9. Tryptases (Tryptase)IBA
10. 4- methyl- N- (3- (4- methylimidazol- 1- yl)- 5- (trifluoromethyl)phenyl)- 3- ((4- pyridin- 3- ylpyrimidin- 2- yl)amino)benzamide (nilotinib)FDA Link

Therapies and Procedures

1. Immunotherapy
2. Drug Therapy (Chemotherapy)
3. Splenectomy
4. Combination Drug Therapy (Combination Chemotherapy)
5. Stem Cell Transplantation