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RNA-Binding Protein FUS

A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.
Also Known As:
FUS Protein; Fusion Protein in Myxoid Liposarcoma; POMp75 Protein; TLS Protein; Translocated in Liposarcoma Protein; hnRNP P2; FUS RNA Binding Protein; RNA Binding Protein FUS; RNA-Binding Protein, FUS; FUS RNA-Binding Protein
Networked: 130 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Mackenzie, Ian R A: 8 articles (12/2017 - 11/2009)
2. Neumann, Manuela: 8 articles (12/2017 - 11/2009)
3. Bozzoni, Irene: 5 articles (01/2020 - 12/2012)
4. Rosa, Alessandro: 5 articles (01/2020 - 12/2012)
5. Rademakers, Rosa: 5 articles (01/2012 - 11/2009)
6. Bigio, Eileen H: 5 articles (11/2011 - 06/2010)
7. Buchman, Vladimir L: 4 articles (05/2020 - 08/2013)
8. Morlando, Mariangela: 4 articles (01/2017 - 12/2012)
9. Cairns, Nigel J: 4 articles (11/2011 - 02/2011)
10. Munoz, David G: 4 articles (11/2011 - 11/2009)

Related Diseases

1. Sarcoma (Soft Tissue Sarcoma)
2. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
3. Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
4. Neurodegenerative Diseases (Neurodegenerative Disease)
5. Cytomegalovirus Infections (Inclusion Disease)

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. RNA (Ribonucleic Acid)
3. Peptides (Polypeptides)
4. Long Noncoding RNA
5. Mutant Proteins (Protein, Mutant)
6. Adenosine Triphosphate (ATP)
7. ropinirole (Requip)
8. DNA-Binding Proteins (DNA Binding Protein)
9. DNA (Deoxyribonucleic Acid)
10. Ubiquitin

Related Therapies and Procedures

1. Ligation
2. Drug Therapy (Chemotherapy)