HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

RNA-Binding Protein FUS

A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.
Also Known As:
FUS Protein; Fusion Protein in Myxoid Liposarcoma; POMp75 Protein; TLS Protein; Translocated in Liposarcoma Protein; hnRNP P2; FUS RNA Binding Protein; RNA Binding Protein FUS; RNA-Binding Protein, FUS; FUS RNA-Binding Protein
Networked: 56 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Mackenzie, Ian R A: 7 articles (11/2011 - 11/2009)
2. Neumann, Manuela: 7 articles (11/2011 - 11/2009)
3. Rademakers, Rosa: 5 articles (01/2012 - 11/2009)
4. Bigio, Eileen H: 5 articles (11/2011 - 06/2010)
5. Munoz, David G: 4 articles (11/2011 - 11/2009)
6. Cairns, Nigel J: 4 articles (11/2011 - 02/2011)
7. Morlando, Mariangela: 3 articles (07/2015 - 12/2012)
8. Bozzoni, Irene: 3 articles (07/2015 - 12/2012)
9. Hayward, Lawrence J: 3 articles (02/2015 - 11/2010)
10. Baker, Matt: 3 articles (07/2011 - 11/2009)

Related Diseases

1. Sarcoma (Soft Tissue Sarcoma)
2. Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
3. Frontotemporal Lobar Degeneration (Semantic Dementia)
4. Cytomegalovirus Infections (Inclusion Disease)
5. Neurodegenerative Diseases (Neurodegenerative Disease)

Related Drugs and Biologics

1. Mutant Proteins (Protein, Mutant)
2. Ubiquitin
3. RNA (Ribonucleic Acid)
4. DNA-Binding Proteins (DNA Binding Protein)
5. RNA-Binding Protein EWS
6. Messenger RNA (mRNA)
7. Proteins (Proteins, Gene)
8. DNA (Deoxyribonucleic Acid)
9. polyglutamine
10. Transcription Factor CHOP