Dynamin III

A subtype of dynamin found expressed exclusively in the testis, lung and brain.

Also Known As:

Dynamin 3; Dynamin, Testicular; T-Dynamin; Testicular Dynamin

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - GTP Phosphohydrolases: 2307
        Dynamins: 825
        Dynamin III: 15
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Vesicular Transport Proteins: 1
      - Dynamins: 825
        Dynamin III: 15
  - Cytoskeletal Proteins: 739
    - Microtubule Proteins: 41
      - Microtubule-Associated Proteins: 3219
        Dynamins: 825
        Dynamin III: 15

Experts

1.	Wang, Lei: 2 articles (01/2021 - 06/2015)
2.	Fa, Jing: 1 article (07/2021)
3.	Cheng, Steven Y: 1 article (03/2021)
4.	Dugan, Sarah: 1 article (03/2021)
5.	Hirsch, Betsy A: 1 article (03/2021)
6.	Huang, Hui-Jie: 1 article (03/2021)
7.	Li, Si-Yang: 1 article (03/2021)
8.	Liu, Chen: 1 article (03/2021)
9.	Liu, Huai-Ze: 1 article (03/2021)
10.	Liu, Xiao-Tong: 1 article (03/2021)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 07/01/2019 - "Recently, rs2421947 in DNM3 (dynamin 3) was reported as a genetic modifier of age at onset (AAO) of LRRK2 G2019S-related Parkinson's disease (PD) in a genome-wide association study in Arab-Berber population. " 01/01/2018 - "A recent study showed that Arab-Berbers GG homozygous at rs2421947(C/G) in the dynamin 3 gene (DNM3) had 12.5 years earlier age at onset of leucine-rich repeat kinase 2 (LRRK2)-associated Parkinson's disease (PD) (L2PD). " 01/01/2018 - "α-synuclein (SNCA) but not dynamin 3 (DNM3) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain."
2.	Neoplasms (Cancer) 07/01/2021 - "Dynamin 3 (DNM3) functions as a tumor suppressor in various malignancies. " 01/01/2021 - "Dynamin 3 (DNM3) has gained increased attention ever since its potential as a tumor suppressor was reported. " 08/04/2011 - "In this report we document, by epigenomic profiling of testicular tissue, that miR-199a is transcribed as antisense of dynamin 3 (chromosome 1q24.3), and hypermethylation of this region is correlated with miR-199a-5p/3p repression and tumor malignancy. " 06/01/2017 - "Dynamin 3 (DNM3) is candidate tumor suppressor against hepatocellular carcinoma (HCC). " 01/01/2018 - "Dynamin 3 (DNM3) is a large GTPase that possesses mechanochemical properties and has been shown to be involved in malignancies. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2013 - "Dynamin 3: a new candidate tumor suppressor gene in hepatocellular carcinoma detected by triple combination array analysis." 06/01/2017 - "Dynamin 3 (DNM3) is candidate tumor suppressor against hepatocellular carcinoma (HCC). " 06/01/2017 - "Dynamin 3 suppresses growth and induces apoptosis of hepatocellular carcinoma cells by activating inducible nitric oxide synthase production."
4.	Megalencephaly 03/02/2021 - "Here we report a young patient with short stature, hypothalamic dysfunction and mild macrocephaly, who carries a maternally inherited 690 kb deletion at Chr.1q24.2 encompassing a noncoding RNA gene, DNM3OS, embedded on the opposite strand in an intron of the DYNAMIN 3 (DNM3) gene. "
5.	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/01/2019 - "Differential expression of the long noncoding RNA (lncRNA) DNM3OS (dynamin 3 opposite strand) and its associated microRNAs (miRNAs) was validated in a murine model of pulmonary fibrosis and in IPF tissue samples. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Leucine (L-Leucine)
3.	Dynamin I
4.	GTP Phosphohydrolases (GTPases)
5.	Protein Isoforms (Isoforms)
6.	Long Noncoding RNA
7.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
8.	Synucleins
9.	Peroxisome Proliferator-Activated Receptors (PPAR)
10.	MicroRNAs (MicroRNA)