Epothilones (Epothilone)

A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).

Also Known As:

Networked: 223 relevant articles (21 outcomes, 41 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Altmann, Karl-Heinz: 12 articles (03/2019 - 03/2003)
2.	Hoffmann, Jens: 6 articles (04/2011 - 07/2008)
3.	Klar, Ulrich: 6 articles (04/2011 - 07/2008)
4.	Gertsch, Jürg: 6 articles (01/2010 - 01/2008)
5.	Huang, Gangliang: 5 articles (01/2020 - 01/2018)
6.	Nicolaou, K C: 5 articles (01/2020 - 03/2000)
7.	Marczak, Agnieszka: 5 articles (08/2019 - 02/2013)
8.	Rogalska, Aneta: 5 articles (08/2019 - 02/2013)
9.	Tang, Li: 5 articles (01/2017 - 01/2003)
10.	Burris, Howard A: 5 articles (10/2012 - 03/2007)

Related Diseases

1.	Neoplasms (Cancer) 03/23/2023 - "This review summarizes results in the study of epothilones against cancer with preclinical results and clinical studies from 2010-2022. " 10/01/2011 - "Phase I clinical and pharmacokinetic study of UTD1, a genetically engineered epothilone analog in patients with advanced solid tumors." 05/15/2008 - "Preclinical studies also have demonstrated synergistic increases in tumor cell killing when the epothilones are combined with other antitumor medications. " 03/15/2008 - "Several epothilones have been evaluated in clinical trials in a variety of tumor types. " 07/01/2007 - "Epothilones demonstrate a linear dose-dependent pharmacokinetic profile, are well tolerated, and exhibit antitumor activity in a variety of tumor types in phase I studies of patients with cancer. "
2.	Breast Neoplasms (Breast Cancer) 12/01/2008 - "Ongoing research aims to define and optimize the efficacy of the epothilones in an attempt to improve the quality of life and overall survival of individuals with breast cancer." 01/01/2017 - "Utidelone, a genetically engineered epothilone analogue, has shown promise as a potential treatment for breast cancer in phase 1 and 2 trials. " 04/01/2008 - "Clinical studies with epothilones for the treatment of metastatic breast cancer." 03/01/2008 - "Also discussed are results from clinical trials of epothilones alone and in combination in patients with breast cancer." 07/01/2007 - "This review summarizes clinical studies of epothilones in patients with metastatic breast cancer. "
3.	Traumatic Brain Injuries (Traumatic Brain Injury) 04/01/2021 - "Importantly, the effect of the epothilones can vary and our most recent contributions to this field indicate that the efficacy of epothilones following traumatic brain injury is dependent upon the age of the animals. " 01/01/2020 - "The pathologic outcomes and efficacy of epothilone treatment following traumatic brain injury is determined by age."
4.	Prostatic Neoplasms (Prostate Cancer) 08/01/2005 - "Epothilones and the next generation of phase III trials for prostate cancer." 07/01/2011 - "Epothilones in prostate cancer." 02/01/2009 - "The epothilones have demonstrated a wide range of clinical activity, including important antitumor effects, in advanced prostate cancer. " 07/01/2007 - "The epothilones have demonstrated potent antitumor activity in vitro and in experimental animal models of prostate cancer. " 07/01/2007 - "Epothilones in prostate cancer: review of clinical experience."
5.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2019 - "Our collective results suggest that treatment with epothilones in combination with autophagy inhibitors present a potentially more effective chemotherapeutic approach for ovarian cancer." 04/01/2011 - "Epothilones in the treatment of ovarian cancer." 01/01/2015 - "Nevertheless, responses to epothilones have been observed in platinum-refractory/resistant ovarian cancer patients. " 12/01/2012 - "These results demonstrated that Gli1 played a key role in driving resistance to patupilone, suggesting that the combination of epothilones and Gli1-targeted agents could be exploited to improve outcomes in ovarian cancer patients resistant to standard treatments." 05/01/2011 - "Further, epothilones and oxaliplatin, already approved drugs for other cancer entities, show promising activity against ovarian cancer; they are even of interest as a first-line treatment option. "

Related Drugs and Biologics

1.	ixabepilone (BMS 247550)
2.	Paclitaxel (Taxol)
3.	Taxoids (Taxanes)
4.	sagopilone
5.	Anthracyclines
6.	taxane
7.	epothilone B (EPO906)
8.	desoxyepothilone B (epothilone D)
9.	Excipients (Suspending Agents)
10.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Castration
4.	Stents
5.	Radiotherapy